Pancreatic Cell News Volume 9.50 | Dec 18 2018

TOP STORY

deltaNp63-Dependent Super Enhancers Define Molecular Identity in Pancreatic Cancer by an Interconnected Transcription Factor Network

Using genomic localization data of deltaNp63 in pancreatic cancer cell lines coupled with epigenome mapping data from patient-derived xenografts, researchers uncovered that deltaNp63 mainly exerts its effects by activating subtype-specific super enhancers. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Low Level Insulin Content within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes

Scientists tested for low amounts of insulin within a large cohort of JDRF nPOD human pancreata across a wide range of ages and type 1 diabetes disease durations. [Diabetes] Abstract

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

To deconvolve the effects of age and obesity in an experimental model of prediabetes, investigators fed young and aged mice either chow or a short-term high-fat/high-sucrose Western diet and examined how weight, glucose tolerance, and β-cell function were affected. [Sci Rep] Full Article

Electrophysiology of the Pancreatic Islet β-Cell Sweet Taste Receptor TIR3

Sucralose was inefficient in the absence of D-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low non-stimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of D-glucose. [Pflugers Arch] Abstract

MIP-1α Induces Inflammatory Responses by Upregulating Chemokine Receptor 1/Chemokine Receptor 5 and Activating c-Jun N-Terminal Kinase and Mitogen-Activated Protein Kinase Signaling Pathways in Acute Pancreatitis

A pancreatic acinar cell line was treated with cerulein to induce in vitro cell acute pancreatitis model. The expression of tumor necrosis factor-α and interleukin-6 and the activation of the c-Jun N-terminal kinase/p38 mitogen-activated protein kinase signaling pathway in stimulated or transfected cells were detected. [J Cell Biochem] Abstract

FTY720 Inhibits the Activation of Pancreatic Stellate Cells by Promoting Apoptosis and Suppressing Autophagy via the AMPK/mTOR Pathway

FTY720 suppressed pancreatic stellate cell (PSC) viability, proliferation and migration. FTY720 inhibited PSC activation, induced PSC apoptosis and suppressed PSC autophagy. [Life Sci] Abstract

PANCREATIC CANCER

Loss of KDM6A Characterizes a Poor Prognostic Subtype of Human Pancreatic Cancer and Potentiates HDAC Inhibitor Lethality

KDM6A knockout cells demonstrated higher vulnerability to histone deacetylase (HDAC) inhibitors through the reactivation of CDKN1A in vitro and in vivo than the KDM6A wild-type. [Int J Cancer] Abstract

c-Src Confers Resistance to Mitotic Stress through Inhibition of DMAP1/Bub3 Complex Formation in Pancreatic Cancer

Scientists showed that the DMAP1/Bub3 complex mediated mitotic stress-induced cellular apoptosis, while this effect was counteracted by c-Src in pancreatic cancer cells. [Mol Cancer] Full Article

ADAM9 Contributes to Vascular Invasion in Pancreatic Ductal Adenocarcinoma

In vitro analysis showed that loss of A disintegrin and a metalloprotease 9 (ADAM9) did not impede cellular proliferation and invasiveness in the basement membrane. [Mol Oncol] Abstract | Full Article

Monensin Inhibits Cell Proliferation and Tumor Growth of Chemo-Resistant Pancreatic Cancer Cells by Targeting the EGFR Signaling Pathway

Using two commonly-used chemo-resistant pancreatic cancer cell lines, investigators showed that monensin suppressed cell proliferation and migration, and cell cycle progression, while soliciting apoptosis in pancreatic cancer lines at a low micromole range. [Sci Rep] Full Article

B7-H5/CD28H Is a Co-Stimulatory Pathway and Correlates with Improved Prognosis in Pancreatic Ductal Adenocarcinoma

When co-cultured with T cells, pancreatic cancer cells with high B7-H5 expression induced a more potent immune reaction indicated by elevated cytokine release and increased proliferation of T lymphocytes compared with cells exhibiting low B7-H5 expression. [Cancer Sci] Abstract

Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News.

Apolipoprotein CIII and Diabetes. Is There a Link?

The authors present the possible mechanisms linking apolipoprotein CIII and deterioration of carbohydrate homeostasis. [Diabetes Metab Res Rev] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Bellicum Reports Safety Results and Promising Activity of Its Controlled CAR-T Candidate BPX-601 in Patients with Advanced Pancreatic Cancer

Bellicum Pharmaceuticals, Inc. reported safety and promising activity of BPX-601 in Part 1 of a Phase I/II dose-escalation study in patients with advanced, metastatic pancreatic cancer expressing prostate stem cell antigen. [Bellicum Pharmaceuticals, Inc.] Press Release

New European Research Project to Understand the Molecular Development of Diabetes

A researcher at the Université Libre de Bruxelles Center for Diabetes Research, Esteban Gurzov has just obtained a Consolidator Grant from the European Research Council to study how metabolic disorders, such as diabetes, develop in patients. [Université Libre de Bruxelles (American Association for the Advancement of Science)] Press Release

University of California and Elsevier Locked in Negotiations

The University of California (UC) is pushing back against the publishing giant Elsevier over fees and access to research papers. The UC system’s five-year contract expires on December 31 and it has prepared for faculty and students to lose access Elsevier’s journals if they don’t reach an agreement in time. [The Scientist] Editorial

South Korean University Delays Vote on Whether to Suspend President

Leaders at the Korea Advanced Institute of Science and Technology decided 6-3 to defer a vote on whether to suspend the university’s president Shin Sung-Chul, who has been accused of making illegal payments to a lab in California – allegations that he denies. The board will take the matter up again at its next meeting. [Nature News] Editorial

NEW 2019 ASCO Annual Meeting
May 31-June 4, 2019
Chicago, Illinois, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Organoid Development (University of Oslo)

Research Technologist – Pancreatic Cell Research (STEMCELL Technologies Inc.)

Professor – Diabetology (Universität Tübingen)

Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey)

Postdoctoral Fellowship – Pancreatic Beta-Cell Development (City of Hope)

Postdoctoral Research Associate – Pancreas Development (University of Illinois)

Computational Biologist – Translational Cancer Research (Technical University of Munich)

Research Lab Specialist – Cancer Biology (University of Southern California)

Postdoctoral Position – Pancreatic Cancer (University Hospitals)

PhD Positions – Cancer Biology (Technical University of Munich)

Bench Research Fellowship – Cardiovascular Disease (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Position – Lung and Pancreatic Cancers (University of California, San Francisco)

Postdoctoral Position – Stem Cells and Diabetes (A*STAR)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Pancreatic Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.