CURRENT PUBLICATIONS LABORATORY RESEARCH Estrogen Receptor-Beta Activated Apoptosis in Benign Hyperplasia and Cancer of the Prostate is Androgen Independent and TNF(Alpha) Mediated Data are indicative of the therapeutic potential of estrogen receptor-beta agonist for treatment of prostate cancer and/or benign prostatic hyperplasia with or without androgen withdrawal. [Proc Natl Acad Sci] Role of Cationic Channel Transient Receptor Potential Vanilloid 2 (TRPV2) in Promoting Prostate Cancer Migration and Progression to Androgen Resistance Researchers report that the nonselective cationic channel transient receptor potential vanilloid 2 is a distinctive feature of castration-resistant prostate cancer. [Cancer Res] Variability in the Androgen Response of Prostate Epithelium to 5(Alpha)-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention Findings suggest that androgen receptor levels may predict the chemopreventive efficacy of 5(alpha)-reductase inhibitors. [Cancer Res] Flavokawain B, a Kava Chalcone, Exhibits Robust Apoptotic Mechanisms on Androgen Receptor-Negative, Hormone-Refractory Prostate Cancer Cell Lines and Reduces Tumor Growth in a Preclinical Model Resarchers have shown that flavokawain B, a kava chalcone, is about 4 to 12 fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, hormone-refractory prostate cancer cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells. [Int J Cancer] Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor-Initiating Cells These studies show for the first time that gossypol treatment induces DNA damage and activates p53. [Mol Cancer Ther] CCR9-Mediates PI3K/AKT Dependent Anti-Apoptotic Signals in Prostate Cancer Cells and Inhibition of CCR9-CCL25 Interaction Enhances the Cytotoxic Effects of Etoposide Researchers show that CC chemokine receptor 9 and its natural ligand CCL25 interaction up regulates anti-apoptotic proteins and down regulate activation of caspase-3 in prostate cancer cells. [Int J Cancer] Inhibition of Glycogen Synthase Kinase-3(Beta) Promotes Nuclear Export of the Androgen Receptor through a CRM1-Dependent Mechanism in Prostate Cancer Cell Lines Results suggest that glycogen synthase kinase-3(beta) is an important element not only in androgen receptor (AR) stability but also significantly alters nuclear translocation of the AR, thereby modulating the androgenic response of human prostate cancer cells. [J Cell Biochem] CLINICAL RESEARCH Finasteride to Prevent Prostate Cancer: Should All Men or Only a High-Risk Subgroup Be Treated? Researchers sought to determine whether prostate-specific antigen levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. [J Clin Oncol] Prognostic Parameters, Complications, and Oncologic and Functional Outcome of Salvage Radical Prostatectomy for Locally Recurrent Prostate Cancer after 21st-Century Radiotherapy Investigators evaluated preoperative prognostic risk factors to predict organ-confined, locally recurrent prostate cancer after primary radiotherapy. [Eur Urol]
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