CURRENT PUBLICATIONS LABORATORY RESEARCH Long-Range Enhancers on 8q24 Regulate c-Myc Here, researchers show that multiple enhancer elements are present within the region of chromosome 8q24 and that they can regulate transcription of Myc. In addition, the enhancer element physically interacts with the Myc promoter via transcription factor Tcf-4 binding and acts in an allele specific manner to regulate Myc expression. [Proc Natl Acad Sci U S A] Oncolysis of Prostate Cancers Induced by Vesicular Stomatitis Virus in PTEN Knockout Mice Results suggest that control of locally advanced human prostate cancer may be achievable through intraprostatic injection and amplification of a safe oncolytic virus, such as VSV(AV3). [Cancer Res] Prosaposin Down-Modulation Decreases Metastatic Prostate Cancer Cell Adhesion, Migration, and Invasion Findings suggest that by a coordinated regulation of ceramide levels, cathepsin D and beta1A-integrin expression, and attenuation of “inside-out” integrin-signaling pathway, prosaposin is involved in prostate cancer invasion and therefore might be used as a molecular target for prostate cancer therapy. [Mol Cancer] Pim1 Kinase Synergizes with c-Myc to Induce Advanced Prostate Carcinoma Results directly show functional cooperativity between c-Myc and PIM1 in prostate tumorigenesis in vivo and support efforts for targeting PIM1 in prostate cancer. [Oncogene] Low Levels of Phosphorylated Epidermal Growth Factor Receptor (pEGFR) in Nonmalignant and Malignant Prostate Tissue Predict Favorable Outcome in Prostate Cancer Patients Low pEGFR immunoreactivity is associated with the favorable prognosis in prostate cancer patients and may provide information about which patients with Gleason score 6 and 7 tumors that will survive their disease even without treatment. Changes in the nonmalignant tissue adjacent to prostate tumors give prognostic information. [Clin Cancer Res] The Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-Regulation of the Alzheimer Amyloid Precursor Protein The data suggest that beta-amyloid precursor protein down-regulation via histone deacetylase inhibition provides a novel mechanism for pancreatic and colon cancer therapy. [J Biol Chem] GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche Results suggest that the activation of GAS6 receptors on prostate cancer in the marrow environment may play a critical role as a molecular switch to establish dormancy. [Neoplasia] Beta-TrCP Inhibition Reduces Prostate Cancer Cell Growth via Upregulation of the Aryl Hydrocarbon Receptor Here researchers show that beta-TrCP depletion suppresses prostate cancer and identify a relevant growth control mechanism. shRNA targeted against beta-TrCP reduced prostate cancer cell growth and cooperated with androgen ablation in vitro and in vivo. [PLoS One] CLINICAL RESEARCH Prostate-Specific Antigen Screening in the United States versus in the European Randomized Study of Screening for Prostate Cancer-Rotterdam Researchers conclude that the efficacy of prostate-specific antigen screening in detecting prostate cancer was lower in the United States than in the European Randomized Study of Screening for Prostate Cancer -Rotterdam. [J Natl Cancer Inst] Phase I/II Study of Preoperative Docetaxel and Mitoxantrone for High-Risk Prostate Cancer Preoperative chemotherapy with docetaxel and mitoxantrone is feasible. Approximately half of the high-risk patients remain free of disease recurrence at 5 years, and clinical and molecular predictors of early recurrence were identified. [Cancer]
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POLICY NEWS
Senate Rejects Stem Cell Legislation By a vote of 21 to 12, the South Dakota Senate shot down a bill that could have repealed South Dakota’s ban on embryonic stem cell treatments. [South Dakota Senate, United States] Parsing National Institutes of Health’s 2011 Budget: Is Big Science Up, Small Science Down? Is National Institutes of Health Director Francis Collins planning to steer his ocean liner of an institute toward “big biology” at the expense of single-investigator grants? [National Institutes of Health, United States] Medvedev Talks Science in Moscow Russian science has been getting some bad press recently, what with a recent report on its declining productivity in scientific papers and a letter from expatriate scientists to the Russian president and prime minister warning of the parlous state of basic research. [Russian Academy of Sciences, Russia] Impersonation of MHRA Staff [Medicines and Healthcare Products Regulatory Agency, United Kingdom] Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States] Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States] Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States] IACUC 101 Workshop and PRIM&R 2010 IACUC Conference: March 21-23, 2010 in Baltimore, MD (NOT-OD-10-059) [National Institutes of Health, United States] Delays in Grant Application Submission Due to Blizzard (NOT-OD-10-060) [National Institutes of Health, United States] Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States] Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]
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EVENTS SMi’s Second Annual Stem Cells 2010 February 15-16, 2010 London, United Kingdom Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4) February 15-20, 2010 Keystone, United States 5th Annual Stem Cell Summit February 16, 2010 New York, United States Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer February 24-27, 2010 Washington, DC, United States The 3rd World Congress on Controversies in Urology (CURy) February 25-28, 2010 Athens, Greece 2010 Genitourinary Cancers Symposium: Progress in Multidisciplinary Management March 5-7, 2010 San Francisco, United States American Association for Cancer Research (AACR) 101st Annual Meeting April 17-21, 2010 Washington, DC, United States International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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