TOP STORY
Statins Inhibit Inflammation Within Prostate Tumors
A new study from Duke University Medical Center shows that statins significantly lower the degree of inflammation within prostate tumors. [Press release from Duke University discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]
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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Consolidation of the Cancer Genome into Domains of Repressive Chromatin by Long-Range Epigenetic Silencing (LRES) Reduces Transcriptional Plasticity
By creating an integrated prostate cancer epigenome map using tiling arrays, researchers show that contiguous regions of gene suppression commonly occur through long-range epigenetic silencing. [Nat Cell Biol]
Molecular Profiling Uncovers a p53-Associated Role for miR-31 in Inhibiting the Proliferation of Serous Ovarian Carcinomas and Other Cancers
Findings reveal that loss of miR-31 is associated with defects in the p53 pathway and functions in serous ovarian cancer and other cancers, suggesting that patients with cancers deficient in p53 activity might benefit from therapeutic delivery of miR-31. [Cancer Res]
Potentiation of TNF-(Alpha)-Induced Tumor Cell Apoptosis by a Small-Molecule Inhibitor for Anti-Apoptotic Protein hPEBP4
Data suggest that IOI-42, as the first chemical inhibitor of anti-apoptotic protein hPEBP4, may serve as a potential antitumor drug by sensitizing tumor cells to apoptotic inducers. [J Biol Chem]
Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells
Observations suggest that epidermal growth factor receptor and sonic hedgehog cascades may represent the potential therapeutic targets of great clinical interest to eradicate the total prostate cancer cell mass and improve the current docetaxel-based therapies against locally advanced and invasive prostate cancers, and thereby prevent metastases and disease relapse. [Mol Cancer Ther]
miR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells
Researchers found that miR-24 regulates apoptosis by targeting FAF1 in cancer cells. These findings suggest that miR-24 could be an effective drug target for treatment of hormone-insensitive prostate cancer or other types of cancers. [PLoS ONE]
MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells
Using immunohistochemistry to localize MYC expression in Lo-MYC transgenic mice, researchers show that morphological and molecular alterations characteristic of high grade prostatic intraepithelial neoplasia arise in luminal epithelial cells as soon as MYC overexpression is detected. [PLoS ONE]
The Transcriptional Regulation of miR-21, Its Multiple Transcripts, and Their Implication in Prostate Cancer
Studies suggest a model where miR-21 contributes to androgen-dependent and androgen-independent prostate cancer growth. [Cell Cycle]
CLINICAL RESEARCH
Risk Factors for Prostate Cancer Detection After a Negative Biopsy: A Novel Multivariable Longitudinal Approach
Piecewise exponential models provide an approach to longitudinal analysis of prostate cancer risk that allows clinicians to see the interplay of risk factors as they unfold over time for individual patients. [J Clin Oncol]
Impact of Ethnicity on Primary Treatment Choice and Mortality in Men With Prostate Cancer: Data From CaPSURE
There is a statistically significant difference in primary treatment for prostate cancer between African American and white men with similar risk profiles. [J Clin Oncol]
A Randomized Phase II Trial of Mitoxantrone, Estramustine and Vinorelbine or Bcl-2 Modulation with 13-Cis Retinoic Acid, Interferon and Paclitaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer: ECOG 3899
Treatment with estramustine and vinorelbine was well tolerated and demonstrated clinical activity in patients with castrate-resistant prostate cancer. Given the adverse effect of 13-cis retinoic acid/interferon-alpha2b with paclitaxel on quality of life, the study of other novel agents that target Bcl-2 family proteins is warranted. [J Transl Med]
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2010 Genitourinary Cancers Symposium: Progress in Multidisciplinary Management
March 5-7, 2010
San Francisco, United States
American Association for Cancer Research (AACR) 101st Annual Meeting
April 17-21, 2010
Washington, DC, United States
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May 29-June 3, 2010
San Francisco, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
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July 12-14, 2010
Nottingham, United Kingdom
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August, 18-21, 2010
Beijing, China
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