Prostate Cell News Volume 1.22 | Jun 18 2010

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    Prostate Cell News 1.22, June 18, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
    Castration-recurrent prostate cancer is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains most, if not all, of the transcriptional activity. Here researchers identify EPI-001, a small molecule that blocked transactivation of the NTD and was specific for inhibition of AR without attenuating transcriptional activities of related steroid receptors. [Cancer Cell]

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    SCIENCE NEWS

    New Prostate Cancer Research Will Have Global Impact
    Combining radiation and hormone therapy in patients with high risk prostate cancer significantly improves the likelihood of patients living longer, according to a new NCIC Clinical Trials Group study conducted at Queen’s. [Queen’s University Press Release]

    University Hospitals Case Medical Center Cardiologists Discover Cancer Risks in Group of Blood Pressure Medications
    Cardiologists have uncovered new research showing an increased risk of cancer with a group of blood pressure medications known as angiotensin-receptor blockers. [Press release from the University Hospitals Harrington-McLaughlin Heart & Vascular Institute discussing online prepublication in Lancet Oncology]

    Polyphenols in Red Wine and Green Tea Halt Prostate Cancer Growth, Study Suggests
    In what could lead to a major advance in the treatment of prostate cancer, scientists now know exactly why polyphenols in red wine and green tea inhibit cancer growth. [Press release from ScienceDaily discussing online prepublication in the FASEB Journal]

    Compound Enhances Cancer-Killing Properties of Agent in Trials
    Adding a second agent may make a new, experimental anti-cancer drug effective against a wide range of cancers, researchers have found. [Press release from the University of Illinois at Chicago College of Medicine discussing online prepublication in the Molecular Cancer Therapeutics]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration
    In this study, researchers show that membrane type 1 matrix metalloproteinase (MT1-MMP)-expressing LNCaP prostate cancer cells display enhanced migration. [Cancer Res]

    Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells
    Here, researchers surprisingly show that poly (ADP-ribose) polymerase 1 is hyperactivated in replicating BRCA2-defective cells. [Cancer Res]

    Expression Profiling Identifies New Function of Collapsin Response Mediator Protein 4 as a Metastasis-Suppressor in Prostate Cancer
    Researchers used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 expression was inversely associated with the lymph node metastasis of prostate cancer. [Oncogene]

    The Sphingosine Kinase-1 Survival Pathway is a Molecular Target for the Tumor-Suppressive Tea and Wine Polyphenols in Prostate Cancer
    Here researchers provide the first evidence that dietary agents, namely, epigallocatechin gallate, resveratrol, or a mixture of polyphenols from green tea or grapevine extract, impede prostate cancer cell growth in vitro and in vivo by inhibiting the SphK1/S1P pathway. [FASEB J]

    CD90/THY1 is Overexpressed in Prostate Cancer-Associated Fibroblasts and Could Serve as a Cancer Biomarker
    Quantitative proteomic analysis of N-glycosylated proteins detected an increased amount of CD90/THY1 in cancer supernatants compared with non-cancer supernatants. [Mod Pathol]

    Role of DNA Methyltransferase 1 in Hormone-Resistant Prostate Cancer
    These findings provide evidence for therapeutically targeting DNA Methyltransferase 1 (DNMT1) in hormone-resistant prostate cancer. [J Mol Med]

    Alpha1 and Beta1 Integrins Enhance the Homing and Differentiation of Cultured Prostate Cancer Stem Cells
    The present study reports the integrin profile of prostate cancer progenitor cells and the role of alpha1 and beta1 integrins in the homing and differentiation of prostate cancer stem cells in vitro. [Asian J Androl]

    CLINICAL RESEARCH

    DNA Vaccine Encoding Prostatic Acid Phosphatase (PAP) Elicits Long-term T Cell Responses in Patients With Recurrent Prostate Cancer
    Researchers have investigated plasmid DNA vaccines and have previously conducted a Phase I trial in which patients with recurrent prostate cancer were vaccinated with a DNA vaccine encoding prostatic acid phosphatase. [J Immunother]


    INDUSTRY NEWS

    Jevtana® (cabazitaxel) Injection Approved by U.S. FDA After Priority Review
    Sanofi-aventis announced that the U.S. Food and Drug Administration (FDA) has granted marketing authorization for Jevtana® (cabazitaxel) Injection in combination with prednisone for the treatment of patients with metastatic hormone-refractory prostate cancer previously treated with a docetaxel-containing treatment regimen. [Sanofi-aventis Press Release]

    OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics
    OncoMed Pharmaceuticals, Inc. and Bayer Schering Pharma AG, Germany, announced a global strategic alliance to discover, develop and commercialize novel anti-cancer stem cell therapeutics targeting the Wnt signaling pathway. [OncoMed Pharmaceuticals, Inc. Press Release]

    OncoVista Inc. Updates with Comprehensive Shareholder Letter
    OncoVista Innovative Therapies, Inc. released a letter to shareholders from Chief Executive Officer, Alexander L. Weis Ph.D. to update shareholders on the Company’s progress and potential. [The Wall Street Journal]

    MMR Information Systems, Inc. Receives Grant From U.S. Patent and Trademark Office to Reinstate Patent to Treat Patients With B Cell Malignancies
    MMR Information Systems, Inc. announced that a petition has been granted by the U.S. Patent and Trademark Office to reinstate its U.S. Patent titled “Method and Composition for Altering a B Cell Mediated Pathology”. [Marketwire]


    POLICY NEWS

    The Path to Personalized Medicine
    The leaders of the National Institutes of Health and the Food and Drug Administration have a shared vision of personalized medicine and the scientific and regulatory structure needed to support its growth. Together, they have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. [Food and Drug Administration and the National Institutes of Health, United States]

    Diseased Cells Fail to Win Approval
    In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for U.S. federal funding, a National Institutes of Health committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States]

    NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health
    Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States]

    Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

    PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-Study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

    Clinical Trials for Medicines Section Updated [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

    Advertising and Supply of Therapeutic Goods to Complementary Healthcare Professionals: Schedule 1 to the Therapeutic Goods Regulations [Therapeutic Goods Administration, Australia]


    EVENTS

    21st Meeting of the European Association for Cancer Research (EACR) 
    June 26-29, 2010
    Oslo, Norway

    Translational Cancer Medicine 2010 – USA
    July 11-14, 2010
    San Francisco, United States

    United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
    July 12-14, 2010
    Nottingham, United Kingdom

    2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
    August 2-4, 2010
    Singapore City, Singapore

    CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
    August 17-19, 2010
    Cambridge, United States

    2010 World Cancer Congress
    August 18-21, 2010
    Shenzhen, China

    Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
    August 23-27, 2010
    Toronto, Canada

    Select Biosciences 3rd Annual Stem Cells Europe Conference
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences 2nd Annual World Biobanking Summit
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences Inaugural Cellular Therapy Summit
    August 24-25, 2010
    Edinburgh, Scotland

    28th World Congress of Endourology and SWL
    September 1-4, 2010
    Chicago, United States

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    35th European Society for Medical Oncology (ESMO) Congress
    October 8–12, 2010
    Milan, Italy

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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