CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation Researchers described a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. [Cancer Cell] A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism AS1411 is a first-in-class anticancer agent, currently in Phase II clinical trials. The data suggest a new model for AS1411 action, as well as a new role for nucleolin in stimulating macropinocytosis, a process with potential applications in drug delivery. [Cancer Res] DLC1 Negatively Regulates Angiogenesis in a Paracrine Fashion In this study, researchers silenced DLC1 in non-malignant prostate epithelial cells to explore its tumor suppression functions. [Cancer Res] Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark The results suggest that ANCCA acts as a pioneer factor in E2F-dependent gene activation and that a novel mechanism involving ANCCA bromodomain may contribute to cancer cell proliferation. [Mol Cell Biol] Research Resource: Estrogen-Driven Prolactin-Mediated Gene-Expression Networks in Hormone-Induced Prostatic Intraepithelial Neoplasia In this study, researchers delineate the specific action(s) of E2 and prolactin in early prostate carcinogenesis by an integrated approach combining global transcription profiling, gene ontology, and gene-network mapping. [Mol Endocrinol] Expression Pattern of Receptor Activator of NF(Kappa)B (RANK) in a Series of Primary Solid Tumors and Related Bone Metastases Researchers retrospectively examined RANK ligand expression by immunohistochemistry in 74 bone metastases tissues from solid tumors, mostly breast, colorectal, renal, lung and prostate cancer. [J Cell Physiol ] Changes in Cortical Cytoskeletal and Extracellular Matrix Gene Expression in Prostate Cancer are Related to Oncogenic ERG Deregulation Specific changes in the cortical cytoskeleton were observed during prostate cancer progression. They parallel changes in the expression of extracellular matrix components and all together appear to be associated with oncogenic ERG overexpression. Researchers hypothesize that these alterations may contribute to the increased invasivity conferred to prostate cancer cells by ERG deregulation. [BMC Cancer] CLINICAL RESEARCH Castration-Dependent Pharmacokinetics of Docetaxel in Patients With Prostate Cancer The objective of this study was to assess whether the low incidence of severe neutropenia in castrated men with prostate cancer treated with docetaxel was the result of changes in systemic clearance. [J Clin Oncol] Biochemical Recurrence Following Robot-Assisted Radical Prostatectomy: Analysis of 1384 Patients with a Median 5-Year Follow-Up In a contemporary cohort of patients with localized prostate cancer, robot-assisted radical prostatectomy confered effective 5-year biochemical control. [Eur Urol] Single-Nucleotide Polymorphisms in p53 Pathway and Aggressiveness of Prostate Cancer in a Caucasian Population In this study, researchers analyzed the association of single-nucleotide polymorphisms in p53, Mdm2, Mdm4 and Hausp genes with prostate cancer clinicopathologic variables in a large hospital-based Caucasian prostate cancer cohort (N = 4073). [ Clin Cancer Res] A Phase II Study of Estramustine, Docetaxel, and Bevacizumab in Men with Castrate-Resistant Prostate Cancer The combination of docetaxel, estramustine, and bevacizumab was tolerable but complicated by toxicity. Although the endpoint of progression-free survival did not meet the desired level, encouraging antitumor activity and overall survival were observed. [Cancer]
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EVENTS (Listed by Date) International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations September 27-28, 2010 San Francisco, United States 35th European Society for Medical Oncology (ESMO) Congress October 8-12, 2010 Milan, Italy American Association for Cancer Research (AACR) Translational Cancer Research for Basic Scientists October 17-22, 2010 Boston, United States NEW 6th Modern Drug Discovery & Development Summit (M3D) October 20-22, 2010 San Francisco, United States NEW American Institute for Cancer Research (AICR) 2010 Annual Research Conference October 21-22, 2010 Washington, DC, United States NEW MENA Oncology Conference October 22-23, 2010 Cairo, Egypt Frontiers in Tumour Progression October 24-27, 2010 Madrid, Spain NEW Select Biosciences 3rd Annual Molecular Diagnostics World Congress October 28-29, 2010 San Diego, United States NEW UAE Cancer Congress 2010 October 28-30, 2010 Dubai, United Arab Emirates NEW 6th National Cancer Research Institute (NCRI) Conference November 7-10, 2010 Liverpool, United Kingdom 9th Annual AACR International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States NEW 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany Cancer Pharmacogenetics: Personalizing Medicine November 22-24, 2010 Madrid, Spain The 10th Annual Meeting of the Society Of Urologic Oncology (SUO) – 10th Annual Winter Meeting December 3-5, 2010 Bethesda, United States NEW 33rd Annual San Antonio Breast Cancer Symposium December 8-12, 2010 San Antonio, United States NEW American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada IMPaCT: Innovative Minds in Prostate Cancer Today 2011 March 9-12, 2011 Orlando, United States NEW The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics March 16-19, 2011 Las Vegas, United States American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States NEW International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada American Association for Cancer Research (AACR) Cancer Research Imaging Camp June 19-24, 2011 St. Louis, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Cell Therapy Technologist (Opexa Therapeutics) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Prostate Cell News. Visit here to post your career opportunities.
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