Prostate Cell News Volume 10.08 | Mar 8 2019

TOP STORY

A Noninvasive Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer: Very Small Nuclear Circulating Tumor Cells

The authors explored very-small nuclear circulating tumor cells as an aggressive biomarker in metastatic castration-resistant prostate cancer. They also explored a biological pathway that potentially drives this morphologic phenomenon. [J Clin Oncol] Abstract

(Ranked by impact factor of the journal)

Effects on Prostate Cancer Cells of Targeting RNA Polymerase III

Depletion of POLR3G selectively triggered proliferative arrest and differentiation of prostate cancer cells, responses not elicited when POLR3GL was depleted. [Nucleic Acids Res] Full Article

COX-2 Mediates Tumor-Stromal Prolactin Signaling to Initiate Tumorigenesis

Ectopic expression of prolactin receptor in mouse cancer cells enhanced micrometastasis, while treatment with the COX-2 inhibitor celecoxib abrogated prolactin secretion by fibroblasts and reduced tumor initiation. [Proc Natl Acad Sci USA] Full Article

Nuclear FGFR2 Negatively Regulates Hypoxia-Induced Cell Invasion in Prostate Cancer by Interacting with HIF-1 and HIF-2

Scientists investigated if nuclear fibroblast growth factor receptor 2 (FGFR2) modulated the hypoxia-inducible factor (HIF)-driven hypoxic response. Using the TCGA database, they found that FGFR2 downregulation was associated with poor prognosis in prostate cancer. [Sci Rep] Full Article

p300/CBP-Associated Factor Promotes Autophagic Degradation of δ-Catenin through Acetylation and Decreases Prostate Cancer Tumorigenicity

p300/CBP-associated factor (PCAF) overexpression in prostate cancer cells markedly reduced δ-catenin levels and suppressed cell growth and motility. PCAF-mediated δ-catenin downregulation inhibited E-cadherin processing and decreased the nuclear distribution of β-catenin, resulting in the suppression of β-catenin/LEF-1-mediated downstream effectors. [Sci Rep] Full Article

AZGP1 Is Androgen Responsive and Involved in AR‐Induced Prostate Cancer Cell Proliferation and Metastasis

Investigators report that alpha‐2‐glycoprotein 1, zinc‐binding (AZGP1) is an androgen‐responsive gene, which is involved in AR‐induced prostate cancer cell proliferation and metastasis. [J Cell Physiol] Abstract

Glycyrrhizin Attenuates the Process of Epithelial-to-Mesenchymal Transition by Modulating HMGB1 Initiated Novel Signaling Pathway in Prostate Cancer Cells

The authors investigated the effect of glycyrrhizin on inhibition of high mobility group box 1 (HMGB1)-induced epithelial-to-mesenchymal transition, a key step of tumor metastasis, in prostate cancer cells. [J Agric Food Chem] Abstract

Surface Modification of Liposomes by a Lipopolymer Targeting Prostate Specific Membrane Antigen for Theranostic Delivery in Prostate Cancer

Differential expression of prostate specific membrane antigen (PSMA) on LNCaP and PC3 cells was confirmed by immunoblotting as well as by uptake of PSMA ligand labeled with ¹⁸F radionuclide. They found that the uptake of ^99mTc-labeled P³-liposomes by LNCaP cells was >3-fold higher than ^99mTc-labeled plain-liposomes; the amount of doxorubicin delivered to LNCaP cells was also found to be >3-fold higher by P³-liposomes. [Materials] Full Article

Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single Cell RNA-seq

Researchers performed a single cell RNA-seq analysis to investigate the phenotypic and functional heterogeneity of adult mouse prostate stromal cells. They identified three major cell populations representing smooth muscle cells and two types of fibroblast cells enriched by Sca-1 and CD90. [iScience] Abstract | Graphical Abstract | Full Article

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Steroid Receptor Signalings as Targets for Resveratrol Actions in Breast and Prostate Cancer

Scientists discuss the novel understanding on the chemopreventive and anti-cancer activities of resveratrol, a phytoalexin found in grapes acting on a plethora of targets. They highlight resveratrol effect on steroid receptors signaling and its potential use in the treatment of hormone-dependent cancer. [Int J Mol Sci] Full Article

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STEMCELL Technologies Wins Deloitte Best Managed Companies Award

STEMCELL Technologies announced that the company has been selected as a winner of Canada’s Best Managed Companies program for 2019. Canada’s Best Managed Companies is the country’s leading business awards program, recognizing excellence in the management abilities and practices of Canadian owned and managed companies with revenues over $15 million. [STEMCELL Technologies Inc.] Press Release

Final Patient Enrolled in Phase IIb Liproca^® Depot Prostate Cancer Study

The last patient has been enrolled in LIDDS Phase IIb study for the localized treatment of prostate cancer. The Phase IIb study will identify the optimal dose for Phase III and test the safety of Liproca^® Depot and its effectiveness in stopping cancer progression. [LIDDS AB (GlobeNewswire, Inc.)] Press Release

Study Finds Gender Imbalances in First-Time NIH Awards

Women receiving their first research grant from the National Institutes of Health are awarded an average of $39,000 less than men, according to an analysis published March 5 in JAMA. [The Scientist] Editorial

Head of US Food and Drug Agency Resigns

Scott Gottlieb, the head of the US Food and Drug Administration (FDA), resigned on 5 March and will depart the agency in one month. [Nature News] Editorial | Opinion

NEW FEBS: From Molecules to Living Systems
July 6-11, 2019
Krakow, Poland

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NEW Postdoctoral Position – Microenvironment & Cancer (Brigham and Women’s Hospital)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK Manchester Institute)

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics (Northwestern University Feinberg School of Medicine)

Advanced Research Assistant – Cellular Generation and Phenotyping (Wellcome Sanger Institute)

Research Assistant II – Cancer Biology (MD Anderson Cancer Center)

Senior Computational Biologist – Molecular Oncology (Cancer Research UK Manchester Institute)

Postdoctoral Positions – Stem Cell and Cancer Biology (Columbia University Irving Medical Center)

Postdoctoral Fellow – Cancer Biology (Thomas Jefferson University)

Assistant Professor – Translational Cancer Research (Texas Tech University Health Sciences Center El Paso)

Postdoctoral Position – Prostate Cancer (University of Trento)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

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