Prostate Cell News 10.26 July 19, 2019 | |
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TOP STORYIn vivo genetic screening identified CCL2 as the top prometastatic gene induced by Polycomb Repressor Complex 1. CCL2 governed self-renewal and induced the recruitment of M2-like tumor-associated macrophages and regulatory T cells, thus coordinating metastasis initiation with immune suppression and neoangiogenesis. [Cancer Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists discerned the mechanisms by which supraphysiological androgen (SPA) inhibited prostate cancer and determined if molecular context associated with anti-tumor activity. SPA produced an androgen receptor-mediated, dose-dependent induction of DNA double-strand breaks, G0/G1 cell cycle arrest and cellular senescence. [J Clin Invest] Abstract EGR1 Regulates Angiogenic and Osteoclastogenic Factors in Prostate Cancer and Promotes Metastasis The authors demonstrated using a prostate cancer model of bone and brain metastasis that early growth response-1 (EGR1) expression regulated angiogenic and osteoclastogenic properties of metastases. [Oncogene] Abstract Regulation of the Unfolded Protein Response through ATF4 and FAM129A in Prostate Cancer Investigators showed that one of the main transcriptional effectors of unfolded protein response, activating transcription factor 4 (ATF4), was essential for prostate cancer growth and survival. [Oncogene] Abstract Scientists used human and murine prostate cancer cell lines to examine the role of tumor burden in tumor aggressiveness, as well as its correlation with cancer stem cell marker levels and IL-6 signaling. [Cancers] Full Article Researchers investigated the effect of growth hormone-releasing hormone (GHRH) on neuroendocrine differentiation in the androgen-dependent prostate cancer cell line LNCaP and the molecular mechanisms underlying these effects. [Invest New Drugs] Abstract MicroRNA-140 Inhibit Prostate Cancer Cell Invasion and Migration by Targeting Yes Proto-Oncogene 1 Scientists showed that miR-140 was downregulated in prostate cancer cells and tissues, and overexpression of miR-140 could significantly suppress their capacities of proliferation, migration, and invasion. [J Cell Biochem] Abstract The authors found that the semi-synthetic cepharanthine derivative, cepharanthine hydrochloride, decreased protein levels of polyglutamine-expanded androgen receptor in the cytoplasm and nucleus. [Eur J Pharmacol] Abstract Ginsenoside Rb1 Inhibits Vascular Calcification as a Selective Androgen Receptor Modulator Using inorganic phosphate-induced calcification of vascular smooth muscle cells, investigators found that ginsenoside Rb1, like testosterone, significantly inhibited calcium deposition in a concentration-dependent manner. [Eur J Pharmacol] Abstract Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News. | |
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REVIEWSThe authors review the available literature on intratumoral expression of docetaxel- and paclitaxel-metabolizing enzymes in mammary, prostate, lung, endometrial, and ovarian tumors. [Cancer Chemother Pharmacol] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSPropanc Biopharma, Inc. announced an update on Propanc’s preparation of PRP, its anti-cancer lead product candidate, for clinical trial application submission and its recently completed reverse stock split. [Propanc Biopharma, Inc.] Press Release | |
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POLICY NEWSThe Plan to Mine the World’s Research Papers Carl Malamud is on a crusade to liberate information locked up behind paywalls — and his campaigns have scored many victories. Now, the 60-year-old American technologist is turning his sights on a new objective: freeing paywalled scientific literature. And he thinks he has a legal way to do it. [Nature News] Editorial Virologists Escorted out of Lab in Canada Canada’s national police force is investigating “possible policy breaches” after researchers were escorted from a lab at Canada’s National Microbiology Laboratory in Winnipeg, CBC News reported. Prominent virologist Xiangguo Qiu, her colleague and husband Keding Cheng, and an unknown number of her students from China were removed from the lab. [The Scientist] Editorial
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EVENTSNEW Victorian Comprehensive Cancer Centre (VCCC) Research Conference 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Officer – Tumor Progression (Garvan Institute of Medical Research) Postdoctoral Researcher – Genitourinary Cancers (CCTI Columbia University) Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University) Research Scientist – Prostate Cancer Progression & Resistance (MD Anderson Cancer Center) Postdoctoral Position – Prostate Biology (University of Washington) Postdoctoral Scientist – Prostate Organoids (Rutgers Cancer Institute of New Jersey) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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