Prostate Cell News Volume 10.42 | Nov 08 2019

TOP STORY

DEPTOR Is an In Vivo Tumor Suppressor That Inhibits Prostate Tumorigenesis via the Inactivation of mTORC1/2 Signals

Researchers showed that levels of both DEPTOR protein and mRNA were substantially decreased in human prostate cancer tissues, which positively correlated with disease progression. DEPTOR depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. [Oncogene] Full Article

(Ranked by impact factor of the journal)

Nuclear Receptor HNF4α Performs a Tumor Suppressor Function in Prostate Cancer via Its Induction of p21-Driven Cellular Senescence

Scientists determined the functional significance of hepatocyte nuclear factor 4α (HNF4α) in prostate cancer. Their results showed that HNF4α exhibited a reduced expression pattern in clinical prostate cancer tissues, prostate cancer cell lines and xenograft model of castration-relapse prostate cancer. [Oncogene] Full Article

The Paracrine Induction of Prostate Cancer Progression by Caveolin-1

Investigators demonstrated that the presence of caveolin-1 in tumor-derived exosomes acted as a potent driver to induced cancer stem cell phenotypes and epithelial-mesenchymal transition in prostate cancer undergoing neuroendocrine differentiation through NFκB signaling pathway. [Cell Death Dis] Full Article

Syntaxin 6-Mediated Exosome Secretion Regulates Enzalutamide Resistance in Prostate Cancer

Scientists showed that enzalutamide-resistant prostate cancer cells secreted significantly higher amounts of exosomes compared to enzalutamide-sensitive counterparts. Inhibition of exosome biogenesis in resistant cells by GW4869 and dimethyl amiloride strongly decreased their cell viability. [Mol Carcinog] Abstract

Network-Based Analysis of Prostate Cancer Cell Lines Reveals Novel Marker Gene Candidates Associated with Radioresistance and Patient Relapse

The authors analyzed established radioresistant cell lines of the prostate cancer cell lines DU145 and LNCaP and compared their gene copy number and expression profiles to their radiosensitive parental cells. [PLoS Comput Biol] Full Article

Long Noncoding RNA DNM3OS Promotes Prostate Stromal Cells Transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 Axes

Collagen Type III (COL3A1) was significantly upregulated by transforming growth factor beta 1 (TGFβ1) in prostate stromal cells and might be involved in DNM3OS function in myofibroblasts upon TGFβ1 stimulation. Upon TGFβ1 stimulation, COL3A1 protein was decreased by DNM3OS silencing. [Aging (Albany NY)] Full Article

miR-181b/Oncostatin M Axis Inhibits Prostate Cancer Bone Metastasis via Modulating Osteoclast Differentiation

Co-culture with miR-181b-5p-overexpressing differentiated Raw264.7 cells suppressed proliferation, migration, and invasion of mouse prostate cancer RM-1 cells, while co-culture with oncostatin M-overexpressing Raw264.7 cells led to opposing cellular effects. [J Cell Biochem] Abstract

Ruthenium (II) Complexes with N, O-Chelating Proline and Threonine Ligands Cause Selective Cytotoxicity by the Induction of Genomic Instability, Cell Cycle Arrest and Apoptosis in Breast and Prostate Tumor Cells

Researchers assessed the antitumoral activities of novel ruthenium complexes coupled to the amino acids proline and threonine in prostate and breast tumor cell lines, and normal cell lines of the lung fibroblast. [Toxicol In Vitro] Full Article | Graphical Abstract

Integrative Proteomic and Phosphoproteomic Profiling of Prostate Cell Lines

Investigators conducted a large SILAC-based Mass Spectrometry experiment to map the proteomes and phosphoproteomes of four widely used prostate cell lines, namely PNT1A, LNCaP, DU145 and PC3, representative of different cancerous and hormonal status. [PLoS One] Full Article

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

The authors identified the metastasis suppressor NDRG1 as a target of E6AP and showed it was key in E6AP induction of mesenchymal phenotype. They showed that treatment of prostate cancer cells with pharmacological agents up-regulated NDRG1 expression suppressed E6AP-induced cell migration. [iScience] Abstract | Full Article | Graphical Abstract

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Plasma Androgen Receptor in Prostate Cancer

The study of cell-free DNA holds great promise for improving treatment in castration-resistant prostate cancer, especially in the advanced stage of the disease. Researchers focus on androgen receptor testing in plasma that may have clinical utility for treatment selection in advanced prostate cancer. [Cancers] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

LIDDS Licensee Jiangxi Puheng Pharma Prepares for Phase III Trial in China

LIDDS AB Jiangxi Puheng Pharma has after reviewing the preliminary results in LPC-004 decided to move ahead and has initiated discussions with Chinese medical authority, CFDA. Liproca^® Depot, is an injectable cancer drug candidate for local treatment of prostate cancer. The Phase III study protocol will be developed in close collaboration with LIDDS. [LIDDS AB (GlobeNewswire, Inc.)] Press Release

21st Century Oncology Co-Leading Trial To Test Innovative New Treatment For Prostate Cancer

Dr. John Sylvester is the lead 21st Century Oncology investigator of a groundbreaking new immunotherapy modulation study that could significantly improve health and quality of life for prostate cancer patients, eliminating surgery and other treatments that can cause incontinence, impotence and other serious side effects. [21st Century Oncology] Press Release

Texas Voters Approve Second Life for State Cancer Funding Agency

On 5 November, Texas voters approved (64% to 36%) a ballot measure to extend the life of its pioneering state cancer research funding agency, CPRIT, by doubling, to $6 billion, the amount of bonds that can be issued to support the agency. [ScienceInsider] Editorial

Report Sketches Vision for UK Research after Brexit

An eagerly awaited external report, commissioned by the government, lays out research priorities and options if those relationships with Europe are severed. It calls for increased spending on R&D nationwide, a new research fellowship program, and larger chunks of money for universities to quickly target research opportunities. [ScienceInsider] Editorial

South Korea Clamps Down on Academics Attending ‘Weak’ Conferences

South Korea’s education ministry wants to stop academics from participating in conferences that it considers “weak” and of little academic value. The ministry announced on 17 October that it will require all universities to adopt measures to vet academics’ travel to overseas conferences so as to “prevent researchers from engaging in poor academic activities”. [Nature News] Editorial

NEW Exosomes in Human Infectious Diseases Conference
March 5-8, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Positions – Cancer Research (Max Delbrück Center for Molecular Medicine)

NEW Senior Research Associate – Chemical Biology and Molecular Cell Biology of Cancer (Lancaster University)

Postdoctoral Position – Identification of RNA Risk Elements in Cancer Biology (University of Maryland Eastern Shore)

Clinical Research Scientist – Investigational Cancer Therapeutics (MD Anderson Cancer Center)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

Postdoctoral Studentship – Genomics of Hereditary Prostate Cancer (University of Manchester)

Postdoctoral Researcher – Prostate Tumor Microenvironment (NorthShore University Health System)

Postdoctoral Researcher – Prostate Cancer (University of California, San Francisco)

Postdoctoral Scholar – Hormone Therapy Resistance in Prostate Cancer (Duke University Medical Center)

Assistant Professor – Biology of Genitourinary Cancers (University of Chicago)

Postdoctoral Fellowship – Prostate Cancer (Weill Cornell Medicine)

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