Prostate Cell News 10.48 December 20, 2019 | |
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TOP STORYScientists report that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) inhibited docetaxel-induced apoptosis of prostate cancer cells, including androgen-independent prostate cancer cells. [Cell Death Differ] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers found that adding R-2-hydroxyglutarate or the mutant isocitrate dehydrogenase 1 mutation occurring at codon 132 could promote prostate cancer cell invasion in androgen receptor-negative PC3 cells or suppress the androgen receptor in androgen receptor-positive C4-2 cells. [Cancer Lett] Full Article The authors performed a drug-repurposing screen by using murine-derived prostate cancer cell lines driven by clinically relevant genotypes. Cells were treated with docetaxel alone, or in combination with drugs from repurposing libraries, with cytotoxicity quantified using High Content Imaging Analysis. [Br J Cancer] Full Article Aurora B Kinase Promotes CHIP-Dependent Degradation of HIF1a in Prostate Cancer Cells Investigators report that prostate tumor xenografts expressed high levels of HIF-1a and showed greatly enhanced growth in response to knockdown of the E3 ligase C-terminus of Hsp70-interacting protein. [Mol Cancer Ther] Abstract Castration-Induced Stromal Remodeling Disrupts the Reconstituted Prostate Epithelial Structure Researchers performed in vivo experiments using the human prostate epithelial cell line BPH-1 and fetal rat urogenital sinus mesenchyme to generate heterotypic tissue recombinants that formed human prostate-like epithelial structure. [Lab Invest] Abstract Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer Scientists report the highly specific, in situ click chemistry driven pretargeted delivery of cytotoxic drug carriers to PSMA(+) prostate cancer cells. [Mol Pharm] Abstract | Full Article FABP5 Coordinates Lipid Signaling That Promotes Prostate Cancer Metastasis The authors showed that the abilities of fatty acid synthase and monoacylglycerol lipase to promote nuclear receptor activation and prostate cancer metastasis were critically dependent upon co-expression of fatty acid binding protein 5 in vitro and in vivo. [Sci Rep] Full Article Ligands exhibited anti-proliferative effect against PC-3 and DU-145 cells with significant increase in calcium level in a dose- and time-dependent manner. [Sci Rep] Full Article Cancer-Stromal Cell Fusion as Revealed by Fluorescence Protein Tracking Red fluorescence protein-tagged LNCaP cells were cocultured with green fluorescence protein-labeled prostate stromal cells for cancer-stromal cell fusion, which was tracked as dual fluorescent cells by fluorescence microscopy. [Prostate] Full Article Investigators report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. [Plant Foods Hum Nutr] Abstract Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News. | |
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REVIEWSExtracellular Vesicles in Urological Malignancies: An Update Extracellular vesicles have an essential functional role in local tumor progression, metastatic spread and the emergence of drug resistance in bladder, kidney and prostate cancer. Thus, extracellular vesicles could be diagnostic, prognostic and predictive biomarkers for these malignancies. [Nat Rev Urol] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSZenith Epigenetics Announces Clinical Advancement of ZEN-3694 Zenith Epigenetics Ltd. announced the significant clinical advances of ZEN-3694, the company’s lead compound being developed for epigenetic combination therapies in oncology. Zenith has completed the Phase Ib/II, ZEN-3694 + enzalutamide combination trial in metastatic castration resistant prostate cancer patients who had progressed on an androgen receptor antagonist, abiraterone and/or enzalutamide. [Zenith Epigenetics, Ltd.] Press Release XTANDI® Approved by US FDA for the Treatment of Metastatic Castration-Sensitive Prostate Cancer Pfizer Inc. and Astellas Pharma Inc. announced that the US FDA has approved a supplemental New Drug Application for XTANDI® for the treatment of patients with metastatic castration-sensitive prostate cancer. [Pfizer, Inc.] Press Release Exelixis, Inc. announced a collaboration agreement with Roche to evaluate cabozantinib, Exelixis’ small molecule inhibitor of receptor tyrosine kinases, in combination with atezolizumab, Roche’s PD-L1 immune checkpoint inhibitor, in patients with locally advanced or metastatic solid tumors. [Exelixis, Inc.] Press Release | |
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POLICY NEWS2020 US Spending Bill Restricts Some Animal Research, Pushes for Lab Animal Retirement Federal research agencies will be under increased pressure to reduce their use of monkeys, dogs, and cats when President Donald Trump signs the final 2020 US spending bill. [ScienceInsider] Editorial Trump Picks Computer Scientist to Lead National Science Foundation US President Donald Trump has nominated Sethuraman Panchanathan, a computer scientist researcher and vice-president at Arizona State University in Tempe, to be the next head of the National Science Foundation. [Nature News] Editorial
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EVENTSNEW Lorne Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Bioinformatician Positions – Prostate Cancer Genomics (Karolinska Institutet) Endowed Chair Faculty – Genitourinary Malignancies Research Center (Cleveland Clinic) Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic) Postdoctoral Associate – Tumor Metastasis (UPMC Hillman Cancer Center) Postdoctoral Positions – Cancer Research (Max Delbrück Center for Molecular Medicine) Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University) Postdoctoral Studentship – Genomics of Hereditary Prostate Cancer (University of Manchester) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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