Prostate Cell News Volume 11.08 | Mar 06 2020

TOP STORY

Lipogenic Signaling Modulates Prostate Cancer Cell Adhesion and Migration via Modification of Rho GTPases

Impaired RhoU activity in fatty acid synthase depleted cells led to reduced adhesion turnover downstream of paxillin serine phosphorylation, which was rescued by addition of exogenous palmitate. [Oncogene] Full Article

(Ranked by impact factor of the journal)

Reverse Transcriptase Inhibitors Promote the Remodeling of Nuclear Architecture and Induce Autophagy in Prostate Cancer Cells

Scientists report that exposure of PC3 metastatic prostate carcinoma cells to both reverse transcriptase inhibitors resulted in decreased proliferation and concomitantly induced genome damage, associated with rearrangements of the nuclear architecture. [Cancer Lett] Abstract

Novel Androgen Receptor Antagonist Identified by Structure-Based Virtual Screening, Structural Optimization, and Biological Evaluation

Assays indicated that structural analogue AT2 was capable of effectively inhibiting the transcriptional function of androgen receptor (AR) and blocking the nuclear translocation of AR like the second-generation AR antagonists. [Eur J Med Chem] Abstract | Graphical Abstract

Neutrophils Are Mediators of Metastatic Prostate Cancer Progression in Bone

Bone marrow neutrophils directly induced apoptosis of prostate cancer in vitro and in vivo, such that neutrophil depletion in bone metastasis models enhanced bone metastatic prostate cancer growth. [Cancer Immunol Immunother] Full Article

Androgen Receptor and Poly(ADP-Ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells

Androgen ablation combined with poly(ADP-ribose) glycohydrolase inhibition synergistically reduced base excision repair capacity in independently derived LNCaP and LAPC4 prostate cancer cell lines. [Sci Rep] Full Article

A Systematic Study of the Impact of Estrogens and Selective Estrogen Receptor Modulators on Prostate Cancer Cell Proliferation

Researchers studied the impact of estrogenic and anti-estrogenic ligands in well-studied in vitro prostate cancer models with appropriate controls, dosages, and estrogen receptor subtype-specific antibodies. [Sci Rep] Full Article

Mutational and Transcriptomic Landscapes of a Rare Human Prostate Basal Cell Carcinoma

The authors applied single-cell genomic amplification and RNA-Seq to a specimen of human prostate basal cell carcinoma. The transcription factor covariance network analysis showed that the basal cell carcinoma tumor cells had distinct regulatory networks. [Prostate] Abstract

Isoform-Specific Lysine Methylation of RORα2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression

Investigators identified the specific N-terminal domain of retinoid acid-related orphan receptor α (RORα2) that enhanced prostate tumor progression and proliferation via lysine methylation-mediated recruitment of coactivator complex pontin/Tip60. [Int J Mol Sci] Full Article

MIR-138-5P Inhibits the Progression of Prostate Cancer by Targeting FOXC1

Researchers showed MIR-138-5P expression level was significantly decreased in prostate cancer cell lines compared with the normal cell line. [Mol Genet Genomic Med] Full Article

Calcitriol Inhibits Lipopolysaccharide-Induced Proliferation, Migration and Invasion of Prostate Cancer Cells through Suppressing STAT3 Signal Activation

Scientists investigated the effects of lipopolysaccharide on proliferation, migration and invasion of prostate cancer cells and the protective effects of 1α,25(OH)₂D₃. [Int Immunopharmacol] Abstract

X-Ray Tomography of Cryopreserved Human Prostate Cancer Cells: Mitochondrial Targeting by an Organoiridium Photosensitizer

Tomograms obtained by cryo-Soft X-ray Tomography of human PC3 prostate cancer cells were treated with organoiridium complex Ir[(C,N)₂(O,O)], irradiated with blue light, and cryopreserved to maintain them in their native state. [J Biol Inorg Chem] Abstract

Upregulation of PACE4 in Prostate Cancer Is Not Dependent on E2F Transcription Factors

Investigators evaluated of E2Fs on PACE4 and PACE4 isoform expression in prostate cancer. They conducted in vitro molecular silencing studies in various prostate cancer cell lines and determined the change in PACE4 expression levels. [Can J Physiol Pharmacol] Abstract

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Knowing What’s Growing: Why Ductal and Intraductal Prostate Cancer Matter

Aggressive cancers often have distinctive pathologies, including intraductal carcinoma of the prostate and ductal adenocarcinoma. The authors review the importance of these pathologies, because they are often overlooked, especially in genomics and preclinical testing. [Sci Transl Med] Abstract

Metastasis-Associated Protein 1-Mediated Antitumor and Anticancer Activity of Dietary Stilbenes for Prostate Cancer Chemoprevention and Therapy

The authors highlight the potential of metastasis-associated protein 1-targeted anticancer and antitumor effects of three dietary stilbenes, namely resveratrol, pterostilbene, and gnetin C, for prostate cancer management. [Semin Cancer Biol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Proscia^® and UCSF Partner to Deliver Artificial Intelligence Applications That Improve the Accuracy and Speed of Cancer Diagnosis

Proscia and the University of California, San Francisco (UCSF) have partnered to introduce artificial intelligence into the practice of pathology. Beginning with prostate cancer, the collaboration will validate the clinical efficacy of computational pathology applications for several high-impact pathology subspecialties. [Proscia] Press Release

Voluntis and Bristol-Myers Squibb to Co-Develop Digital Therapeutics for Oncology

Voluntis announced a collaboration agreement to create and investigate digital therapeutic solutions that will support cancer patients. Leveraging Theraxium Oncology, Voluntis’ core platform for digital therapeutics in oncology, the collaboration will evaluate potential solutions that will support management of patient symptoms and remote monitoring by healthcare providers. [Voluntis] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW Cambridge International Stem Cell Symposium 2020
September 27-29, 2020
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Prostate Cancer (University of Washington)

Postdoctoral Researcher – Cellular Metabolism and Metabolic Regulation (Flanders Institute for Biotechnology)

Head – Single Cell Research (Sloan Kettering Institute)

Senior Laboratory Research Scientist – Autophagy in Cancer (The Francis Crick Institute)

Postdoctoral Studentship – Stress Signaling and Prostate Cancer (University of Oslo)

Postdoctoral Fellow – Prostate Tumorigenesis (University of Cincinnati)

Postdoctoral Fellow – RNA Splicing in Cancer (The University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Organoid Models of Prostate Cancer (University of Freiburg)

Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

Postdoctoral Fellow – Cancer Biology (City of Hope)

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