Prostate Cell News Volume 11.15 | May 01 2020

TOP STORY

Regenerative Potential of Prostate Luminal Cells Revealed by Single-Cell Analysis

Using single-cell RNA sequencing, researchers identified a rare luminal population in the mouse prostate that expressed stemlike genes and a large population of differentiated cells. [Science] Abstract

(Ranked by impact factor of the journal)

The Landscape of RNA Polymerase II Associated Chromatin Interactions in Prostate Cancer

Scientists mapped RNA Polymerase II associated chromatin interactions in normal prostate cells and prostate cancer cells. They discovered thousands of enhancer-promoter, enhancer-enhancer, as well as promoter-promoter chromatin interactions. [J Clin Invest] Abstract | Graphical Abstract

miR-26a Regulates Extracellular Vesicle Secretion from Prostate Cancer Cells via Targeting SHC4, PFDN4, and CHORDC1

Investigators identified miR-26a involved in extracellular vesicle (EV) secretion from prostate cancer cells. In addition, they found that SHC4, PFDN4, and CHORDC1 genes regulate EV secretion in prostate cancer cells. [Sci Adv] Full Article

Small-Molecule Inhibitor Targeting Orphan Nuclear Receptor COUP-TFII for Prostate Cancer Treatment

Through blocking COUP-TFII’s oncogenic activity in prostate cancer, the inhibitor efficiently exerted a potent antitumor effect in xenograft mouse models and patient-derived xenograft models. [Sci Adv] Full Article

Crosstalk between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF

Compared with a benign prostate, high-grade prostate cancer patient tissue was negatively correlated with promyelocytic leukemia zinc finger (PLZF) expression. PLZF depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. [Cancers] Abstract | Download Full Article

PCAT6 Mediates Cellular Biological Functions in Gastrointestinal Stromal Tumor via Upregulation of PRDX5 and Activation of Wnt Pathway

Ki67 staining, colony formation and trypan blue staining assays revealed that prostate cancer associated transcript 6 (PCAT6) boosted gastrointestinal stromal tumor (GIST) cell proliferation but inhibited cell apoptosis. PCAT6 promoted GIST cell proliferation and stemness via sponging miR-143-3p to upregulate peroxiredoxin 5. [Mol Carcinog] Abstract

Canine Prostatic Cancer Cell Line (LuMa) with Osteoblastic Bone Metastasis

Cell proliferation and gene expression of LuMa were measured and compared to three other canine prostatic cancer cell lines in vitro. The effect of LuMa cells on calvaria and murine preosteoblastic cells was measured by quantitative reverse-transcription polymerase chain reaction and alkaline phosphatase assays. [Prostate] Abstract

Hyaluronan-Metal Gold Nanoparticle Hybrids for Targeted Tumor Cell Therapy

Cell viability assays performed on normal human umbilical vein endothelial and prostate tumor cells, demonstrated an increased cytotoxicity in neuroblastoma compared to prostate cancer cells upon the cellular treatments by HA-AuNP compared to the bare AuNP. [Int J Mol Sci] Abstract | Download Full Article

miR-484 Is Associated with Disease Recurrence and Promotes Migration in Prostate Cancer

Scientists revealed that increased miR-484 in prostate tumors associated with early disease recurrence, while miR-484 expression in human prostate cancer cells enhanced cancer cell mobility. [Biosci Rep] Full Article

The Effect of Arbutin on The Expression of Tumor Suppressor P53, BAX/BCL-2 Ratio and Oxidative Stress Induced by Tert-Butyl Hydroperoxide in Fibroblast and LNCaP Cell Lines

The LNCaP and fibroblast cell lines were pre-treated with arbutin. After 24 hours, t-BHP was added to the cells. The authors showed that arbutin decreased cell viability, induced apoptosis and increased BAX/BCL-2 ratio in LNCaP cells at some specific concentrations. [Cell J] Abstract

Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News.

Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics

The authors summarize the specific roles of zinc in several cancer types focusing on prostate cancer. The relationship between prostate cancer and the dysregulation of zinc homeostasis is examined in detail in an effort to understand the role of zinc in prostate cancer. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

BioXcel Therapeutics Announces Initiation of a Phase II Study of BXCL701 in Combination with a PD-1 Inhibitor for Treatment Emergent Neuroendocrine Prostate Cancer

BioXcel Therapeutics announced the initiation of the Phase II efficacy portion of the Phase Ib/II trial of BXCL701 in combination with pembrolizumab for treatment emergent Neuroendocrine Prostate Cancer. [BioXcel Therapeutics] Press Release

Editas Medicine Initiates IND-Enabling Activities for EDIT-201, an Allogeneic NK Cell Medicine for the Treatment of Solid Tumor Cancers

Editas Medicine, Inc. announced the initiation of IND-enabling activities for EDIT-201, an allogeneic natural killer (NK) cell medicine for the treatment of solid tumor cancers. [Editas Medicine, Inc.] Press Release

The Pandemic’s Effects on Recruiting International STEM Trainees

Pandemic-related concerns that have arisen for science trainees—shuttered labs, research and education delays, anxiety—are applicable across the board. But international graduate students and postdocs face a suite of unique challenges that raise uncertainty about recruiting and supporting this critical group of researchers in the future. [The Scientist] Editorial

Students Stand Up for Sub-Contracted Workers amid COVID-19 Crisis

Students at a number of universities have been advocating for the payment of employees, and especially contracted workers who are more vulnerable to layoffs, as campuses shut down during the COVID-19 pandemic. [The Scientist] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Researcher – Translational Cancer Research (Johannes Kepler University of Linz)

Associate Professor – Cancer Biology (University of Cincinnati)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Position – Cancer Cell Biology and Drug Discovery (University of Luxembourg)

Postdoctoral Research Fellow – Molecular Oncology (Genentech)

Postdoctoral Fellow – Solid Tumor Microenvironment Research (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Prostate Cancer (University of Washington)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.