Prostate Cell News Volume 11.21 | Jun 12 2020

TOP STORY

Structural Basis of Prostate-Specific Membrane Antigen Recognition by the A9g RNA Aptamer

The analysis of the PSMA/aptamer interface allowed for identification of key interactions critical for nanomolar binding affinity and high selectivity of A9g for human prostate-specific membrane antigen. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation

Prostate stem-progenitor cells were enriched by spheroid culture from normal human primary or immortalized prostate epithelial cells, and their differentiation capability was evaluated by organoid culture. [Environ Health Perspect] Full Article

p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer

STUB1 inhibited androgen receptor (AR) activity, AR-V7 levels, and prostate cancer cell growth partly through degradation of JMJD1A. [Cancer Res] Abstract

Single Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells

Differential gene expression analysis between resistant and sensitive cells revealed 182 differentially expressed genes common to both prostate cancer cell lines. [Mol Cancer Res] Abstract

Aspartate β-Hydroxylase Targeting in Castration Resistant Prostate Cancer Modulates the NOTCH/ HIF1α/GSK3β Crosstalk

In castration-resistant prostate cancer cells, inhibition of aspartyl β hydrolase expression obtained through specific siRNA or culturing cells in hypoxic conditions, reduced cell proliferation, invasion and cyclin D1 expression through modulation of the NOTCH signalling. [Carcinogenesis] Abstract

Development of ¹⁷⁷Lu-scFvD2B as a Potential Immunotheranostic Agent for Tumors Overexpressing the Prostate Specific Membrane Antigen

In vitro, ¹⁷⁷Lu-scFvD2B disclosed a higher binding and internalization in LNCaP compared to PC3 (negative control) human prostate cancer cells. [Sci Rep] Full Article

Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

Aspergilsmin C and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC₅₀ values between 2.7-7.3 μM. [Mar Drugs] Full Article

Development of ROS-Responsive Amino Acid-Based Poly(Ester Amide) Nanoparticle for Anticancer Drug Delivery

The L-methionine poly(ester amide) nanoparticles was sensitive to high intracellular reactive oxygen species (ROS) level of PC3 prostate cancer cells. [J Biomed Mater Res A] Abstract

LINC00689 Promotes Prostate Cancer Progression via Regulating miR-496/CTNNB1 to Activate Wnt Pathway

Knock down of LINC00689 repressed prostate cancer cell proliferation, migration and invasion, and initiated prostate cancer cell apoptosis. [Cancer Cell Int] Full Article | Graphical Abstract

Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of ^99mTc-Tricarbonyl-Based Radiopharmaceuticals

The ^99mTc-radiopeptide was evaluated in vitro with PC-3 cells and in Fox-1^nu mice bearing PC-3 xenografts including a direct comparison with a reference conjugate lacking the sorbitol moiety. [Molecules] Full Article

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An Update on Vitamin D Signaling and Cancer

The authors provide an update on the molecular basis of vitamin D signaling, the effects of 1,25(OH)²D³ on the epigenome and transcriptome, and its relationship to cancer prevention and therapy. [Semin Cancer Biol] Full Article

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Debiopharm Partners with Verity Pharmaceuticals for the Exclusive US Commercialization of Trelstar^® for Prostate Cancer

Debiopharm and Verity Pharmaceuticals Inc. announced having entered into an exclusive agreement that grants Verity Pharmaceuticals Inc., in the United States of America, the rights to commercialize Trelstar^® a hormone therapy for patients living with prostate cancer. [Debiopharm (PR Newswire Association LLC)] Press Release

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected. [Nature News] Editorial

NIH Strengthens Policies to Alert Agency to Sexual Harassment by Grantees

The National Institutes of Health (NIH) is tightening grant rules that until now have sometimes left the agency in the dark about sexual harassment cases involving researchers it supports. [ScienceInsider] Editorial

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NEW Postdoctoral Position – Cancer Biology (Berlin School of Integrative Oncology Charité)

Postdoctoral Studentship – Magnetic Resonance Guided Radiation Therapy on Prostate Cancer (Universitätsklinikum Tübingen)

Postdoctoral Position – 3D Genome Organization in Prostate Cancer (Karolinska Institutet)

Postdoctoral Fellow – Prostate Cancer Research (The Vita-Salute San Raffaele University)

Postdoctoral Fellow – Cancer Metabolism Research (Augusta University)

Postdoctoral Fellowship – Molecular Mechanisms in Prostate Cancer (Cleveland Clinic)

Associate Professor – Prostate Disease Research (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Position – Prostate Cancer (University of Washington)

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