Prostate Cell News Volume 11.26 | July 17 2020

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    PCN 11.26 | July 17 2020


    Prostate Cell News by STEMCELL Technologies
    Vol. 11.26 – 17 July, 2020
    TOP STORY

    Skp2 Dictates Cell Cycle-Dependent Metabolic Oscillation between Glycolysis and TCA Cycle

    Scientists found that elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.
    [Cell Research]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    A Rare Variant of African Ancestry Activates 8q24 lncRNA Hub by Modulating Cancer Associated Enhancer

    The authors showed that the variant rs72725854 was present in a prostate cancer-specific enhancer at 8q24 locus.
    [Nature Communications]

    Full Article

    MEIS1 Down-Regulation by MYC Mediates Prostate Cancer Development through Elevated HOXB13 Expression and AR Activity

    Knockdown of MYC expression in prostate cancer cells increased the expression of MEIS1 and increased the occupancy of MYC at the MEIS1 locus.
    [Oncogene]

    Full Article

    WFDC2 Suppresses Prostate Cancer Metastasis by Modulating EGFR Signaling Inactivation

    Scientists revealed that overexpression of WAP four-disulfide core domain 2 (WFDC2), and addition of recombinant protein HE4 could significantly inhibit prostate cancer metastasis in vivo and in vitro.
    [Cell Death & Disease]

    Full Article

    NCL Inhibition Exerts Antineoplastic Effects against Prostate Cancer Cells by Modulating Oncogenic MicroRNAs

    Investigators demonstrated that nucleolin (NCL) was expressed on the surface of all three tested cell lines and that NCL inhibition resulted in reduced proliferation and migration.
    [Cancers]

    Full Article

    Neuroendocrine Differentiation in Usual-Type Prostatic Adenocarcinoma: Molecular Characterization and Clinical Significance

    Benign neuroendocrine cells expressed significantly lower quantified androgen receptor levels compared with paired benign luminal cells.
    [Prostate]

    Abstract

    Differential Impact of Paired Patient-Derived BPH and Normal Adjacent Stromal Cells on Benign Prostatic Epithelial Cell Growth in 3D Culture

    Coculture of the primary stromal cells with benign human prostate epithelial cell lines BHPrE1 or benign prostatic hyperplasia (BPH)-1 was performed in three‐dimensional Matrigel to determine the impact of primary stromal cells derived from BPH on epithelial proliferation.
    [Prostate]

    Abstract

    CXCL12γ Induces Human Prostate and Mammary Gland Development

    Overexpression of CXCL12γ promoted the reprogramming of cells with a differentiated luminal phenotype to a nonluminal phenotype in both prostate and mammary epithelial cells.
    [Prostate]

    Abstract

    Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line

    Scientists investigated the combined effect of curcumin and metformin on the LNCaP prostate cancer cell line. LNCaP cells were treated with curcumin, metformin, and their combination at different concentrations.
    [Nutrition and Cancer-An International Journal]

    Abstract

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    REVIEWS

    Prostate Cancer Liver Metastasis: Dormancy and Resistance to Therapy

    The molecular underpinnings of how the liver aids and protects prostate cancer cells seeding, colonization and resistance was discussed.
    [Seminars in Cancer Biology]

    Abstract

    Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

    The authors summarize the current knowledge of therapeutic induction and intracellular pathways of androgen receptor-mediated cellular senescence.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Data Manager – Pan-Prostate Cancer Group

    European Molecular Biology Laboratory – Hinxton, Cambridge, United Kingdom

    Postdoctoral and Technician Position – Molecular Mechanism of Cancer

    Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States

    Postdoctoral Fellow – Prostate Cancer Biology

    University of Maryland, Baltimore – Baltimore, Maryland, United States

    Postdoctoral Position – Cancer Biology

    Berlin School of Integrative Oncology Charité – Berlin, Germany

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    > See All Jobs

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