Prostate Cell News Volume 11.33 | Sep 4 2020

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    PCN 11.33 | 4 sept 2020


    Prostate Cell News by STEMCELL Technologies
    Vol. 11.33 – 4 September, 2020
    TOP STORY

    Chromatin
    Binding of FOXA1 Is Promoted by LSD1-Mediated Demethylation in Prostate Cancer

    Researchers showed in prostate cancer cells that LSD1 associated with FOXA1 and active enhancer markers, and that LSD1 inhibition globally disrupted FOXA1 chromatin binding.
    [Nature Genetics]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Pleiotropic
    Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

    Scientists cultured hormone receptor-positive breast cancer and prostate cancer spheroids and patient-derived organoids in 3D extracellular matrices alone or together with bone marrow stromal cells.
    [Cancer Research]

    Full Article

    PLCÉ›
    Maintains the Functionality of AR Signaling in Prostate Cancer via an Autophagy-Dependent Mechanism

    Investigators found that phospholipase C epsilon (PLCÉ›) was highly expressed in prostate cancer samples, and was closely associated with androgen receptor signaling activities.
    [Cell Death & Disease]

    Full Article

    Multifunctional
    Nanobubbles Carrying Indocyanine Green and Paclitaxel for Molecular Imaging and the Treatment of Prostate Cancer

    The authors prepared multifunctional nanobubbles carrying indocyanine green and paclitaxel and studied their applications in ultrasound imaging of prostate cancer.
    [Journal of Nanobiotechnology]

    Full Article

    Co-Targeting
    PIM and PI3K/mTOR Using Multikinase Inhibitor AUM302 and a Combination of AZD-1208 and BEZ235 in Prostate Cancer

    Researchers investigated the novel multikinase PIM/PI3K/mTOR inhibitor, AUM302, versus a combination of the PIM inhibitor, AZD-1208, and the PI3K/mTOR inhibitor BEZ235 to determine their impact on mRNA and phosphoprotein expression.
    [Scientific Reports]

    Full Article

    MicroRNA-107
    Enhances Radiosensitivity by Suppressing Granulin in PC-3 Prostate Cancer Cells

    Scientists found microRNA-107 enhanced radiosensitivity by regulating granulin in prostate cancer cells. MiR-107 was downregulated and granulin was upregulated in response to ionizing radiation in prostate cancer cells.
    [Scientific Reports]

    Full Article

    Immortalization
    of Human Primary Prostate Epithelial Cells via CRISPR Inactivation of the CDKN2A Locus and Expression of Telomerase

    Researchers describe the establishment of immortalized normal prostate epithelial cell line models using CRISPR technology to inactivate the CDKN2A locus concomitantly with ectopic expression of an hTERT transgene.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    Novel
    Functions of the Luteinizing Hormone/Chorionic Gonadotropin Receptor in Prostate Cancer Cells and Patients

    To elucidate the influence of luteinizing hormone/choriogonadotropin receptor (LHCGR) on prostate cancer development, scientists investigated the presence and effects of LHCGR in prostate cancer.
    [PLoS One]

    Full Article

    Virtual Conference Exhibition: Organoids
    REVIEWS

    Animal Models of Benign Prostatic Hyperplasia

    Scientists outline the present status quo for animal models of benign prostatic hyperplasia (BPH), comparing the pros and cons with respect to their ability to mimic the etiological, histological, and clinical hallmarks of BPH.
    [Prostate Cancer and Prostatic Diseases]

    Abstract

    INDUSTRY AND POLICY NEWS

    Telix Pharmaceuticals Enters Strategic Collaboration with Varian Medical Systems for Advanced Prostate Imaging

    Telix Pharmaceuticals Limited announced it has entered into a strategic collaboration agreement with Palo Alto-based Varian Medical Systems, to evaluate the use of advanced prostate cancer imaging within Varian’s radiation treatment planning platform.
    [Telix Pharmaceuticals Limited]

    Press Release

    Israeli
    Startup Deploys AI-based Solution for Prostate Cancer Detection

    Ibex Medical Analytics announces the first US deployment of its AI-powered solution for cancer detection in pathology, at the CorePlus Servicios Clínicos y Patológicos, LLC.
    [Ibex Medical Analytics]

    Press Release

    FEATURED EVENT

    Cancer Research & Oncology 2020

    October 7 – 8
    Virtual


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    JOB OPPORTUNITIES


    Postdoctoral and Technician Position – Molecular Mechanism of Cancer

    Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States

    Postdoc – Cancer Biology and Cancer Microenvironments

    University of Copenhagen – Copenhagen, Denmark


    Postdoctoral Research Associate – Translational Cancer

    University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States

    Postdoctoral Position – Immune Microenvironment, Stem Cell, and Cancer

    Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral
    Fellowship – Molecular Mechanisms in Prostate Cancer

    Cleveland Clinic – Cleveland, Ohio, United States

    > See All Jobs

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