 | | Vol. 11.34 – 11 September, 2020 |
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| Researchers showed that androgen receptor signaling in the macrophage-like THP-1 cell line supported prostate cancer cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signaling and expression of its downstream cytokines.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that CAV1 could be secreted from specific prostate cancer types in an inverted vesicle-associated form consistent with the features of bioactive CAV1 secretion.
[Autophagy] |
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| Scientists identified a group of super enhancers that were abnormally activated in Enz-resistant castration-resistant prostate cancer cells and associated with enhanced transcription of a subset of tumor promoting genes such as CHPT1.
[Oncogene] |
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| EGFR status was compared to clinical parameters and multiple molecular factors were assessed using immunohistochemistry and gene ontology analysis. The functional aspect of EGFR was evaluated by plating PC-3 cells on soft and rigid matrices.
[British Journal of Cancer] |
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| Matrix metalloproteinase (MMP)-3 ablation in prostate cancer cell lines significantly reduced in vitro growth combined with lowered AKT and ERK phosphorylation and total VEGFR1 and FGFR3 protein levels.
[Neoplasia] |
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| Researchers observed a positive correlation between AKR1C3 and androgen receptor splice variant 7 (AR-V7) staining in tissues from prostate rebiopsy at metastatic castration‐resistant prostate cancer (mCRPC). Mechanistically, AKR1C3 interacted with AR-V7 protein in CRPC cells, which could reciprocally inhibit AR-V7 and AKR1C3 protein degradation.
[Journal of Cellular and Molecular Medicine] |
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| Scientists demonstrated that adhesion GPCR 205 could be activated by androgens to stimulate the Rho signaling pathway, a pathway that plays an important role in prostate tumor cell metastasis.
[PLoS One] |
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| Scientists evaluated the efficacy of zingerone at different doses on the prostate cancer cell line regarding apoptosis, upstream signing molecules such as Akt/mTOR, and migration metastasis.
[Journal of Biochemical and Molecular Toxicology] |
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| The authors unravel the gene network and identified biologic pathways that impacted activation of the androgen receptor, mesenchymal epithelial transition and chemokines associated with metastasis in the prostate cancer tissue from 639 radical prostatectomy specimens.
[Urologic Oncology-Seminars and Original investigations] |
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| ImCheck Therapeutics announced that the independent Safety Review Committee for the EVICTION Phase I/II clinical trial for its lead antibody ICT01 unanimously approved dose escalation in the solid tumor indications and the start of enrollment in the two other arms of the study.
[ImCheck Therapeutics] |
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| | Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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