 | | Vol. 12.03 – 29 January, 2021 |
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| Researchers developed AMG 160, a half-life extended bispecific T-cell engager immuno-oncology therapy that bound prostate-specific membrane antigen on prostate cancer cells and CD3 on T cells for treatment of metastatic castration-resistant prostate cancer.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that mediators of ferroptosis were expressed in treatment-resistant prostate cancer. They further demonstrated that treatment-resistant prostate cancer cells were sensitive to two ferroptosis inducers.
[Cancer Research] |
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| To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, scientists investigated the impact of MYC overexpression on 800 surface proteins in three isogenic model cell lines either of B cell or prostate cell origin engineered to have high or low MYC levels.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| In vitro in clear cell renal cell carcinoma cell lines via modulating lncRNA-TANAR/TWIST1 signals.
[Oncogene] |
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| The authors report that prostate cancer associated fibroblasts expressed a transcriptional-incompetent androgen receptor.
[Cell Death & Disease] |
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| Scientists analyzed the role of estrogen receptor α (ERα) and ERβ in the activation of SRC, and the involvement of SRC and PI3K/AKT on invasion and colony formation of the PC-3 cells.
[International Journal of Molecular Sciences] |
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| Researchers investigated the release of miR-424 in circulating small extracellular vesicles or exosomes from prostate cancer patients and assessed the functional implications in multiple experimental models.
[Communications Biology] |
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| The authors demonstrated the effect of Psoralea corylifolia L. seed against benign prostatic hyperplasia (BPH), mediated by the regulation of prostate cell proliferation and apoptosis, in dihydrotestosterone -stimulated normal human prostate cell lines and testosterone propionate-induced BPH rat.
[Journal of Ethnopharmacology] |
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| Prostate-specific antigen (PSA)+ and PSA−/lo cells were successfully separated from LNCaP xenograft tumors after prostate- PSAP-GFP vector infection and FACS.
[Translational Oncology] |
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| The authors discuss the pathophysiology and effects of androgen-deprivation therapy and glucocorticoids on skeletal endpoints, as well as the awareness and management of bone fragility.
[Trends in Endocrinology and Metabolism] |
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| Promaxo, Inc. announced that they have received IRB approval from WCG Clinical Services. The approval will enable a multi-center feasibility study of the Promaxo MRI System for prostate biopsy guidance.
[Promaxo, Inc. (Business Wire, Inc.)] |
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| TeneoBio, Inc. announced that their investigational new drug application (IND) for TNB-585, a bispecific T-cell engaging antibody for the treatment of metastatic castrate resistant prostate cancer was cleared for the initiation of Phase I clinical studies by the FDA on January 23, 2021.
[TeneoBio, Inc.] |
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| February 3 – 23, 2021
Virtual |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Novo Nordisk – Copenhagen, Denmark |
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| | Medical University of Gdańsk – Gdańsk, Poland |
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Cancer Stem Cell News
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Intestinal Cell News
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Pancreatic Cell News
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