 | | Vol. 12.04 – 5 February, 2021 |
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| The authors showed that mutually exclusive prostate cancer driver alterations involving the ERG transcription factor and the ubiquitin ligase adaptor SPOP were synthetic sick.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report mesenchymal stem cell-derived interleukin-28 (IL-28) triggered prostate cancer cell apoptosis via IL-28 receptor alpha STAT1 signaling.
[Nature Communications] |
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| Investigators used molecular, genetic, and pharmacological approaches to elucidate an androgen receptor-mediated autophagy cascade involving Ca22+/calmodulin-dependent protein kinase kinase 2 (CAMKK2), 5’-AMP-activated protein kinase (AMPK), and Unc-51 like autophagy activating kinase 1 (ULK1), but independent of the canonical mechanistic target of rapamycin activity.
[Oncogene] |
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| In vitro cellular uptake studies with 18F-enzalutamide and 16β-18F-fluoro-5α-dihydrotestosteron were performed in LNCaP and HEK293 cells.
[Journal of Nuclear Medicine] |
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| Scientists showed that stable overexpression of MED19 in androgen-dependent LNCaP cells promoted growth under conditions of androgen deprivation.
[PLoS Genetics] |
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| The authors hypothesized that SOD2 Val16A single nucleotide polymorphism may promote epithelial-mesenchymal transition. They analyzed SOD2 expression and genotype in various prostate cell lines.
[Antioxidants] |
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| Researchers explored how prostate circulating tumor cells could resist cell death in response to forces of >1,000 dyn/cm2. Human prostate cancer cell lines were used to represent cells of different metastatic origins.
[Journal of Cell Science] |
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| Scientists applied the HOX codes to the transcriptomic profiles of prostate cancer samples and found that the majority of prostate adenocarcinoma samples sustained a prostate-specific HOX code whereas the majority of neuroendocrine prostate cancer (NEPCa) samples did not, which reflected the anaplastic nature of NEPCa.
[Scientific Reports] |
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| The anticancer activity of docetaxel encapsulated gold nanoparticles were evaluated with prostate cancer cell lines.
[Scientific Reports] |
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| The authors found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed long noncoding RNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells.
[Genes] |
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| The authors focus on the various bispecific constructs that are presently in development for the treatment of prostate cancer and discuss underlying concepts and the state of clinical evaluation as well as future perspectives.
[Cancers] |
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| AIkido Pharma, Inc. announced that the company executed a Two Million Dollar Convertible Promissory Note Purchase Agreement with Convergent Therapeutics, Inc., securing an early investment in Convergent. Convergent has exclusive rights to technology related to next-generation radiopharmaceutical therapy for prostate cancer that is covered by multiple issued US and foreign patents.
[AIkido Pharma, Inc. (PR Newswire, LLC)] |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Oslo University Hospital – Oslo, Norway |
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| | Vall D’Hebron Institute of Oncology – Barcelona, Spain |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Novo Nordisk – Copenhagen, Denmark |
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