 | | Vol. 12.11 – 26 March, 2021 |
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| Scientists report that SUMOylation regulated the binding of hexokinase 2 to mitochondria. They found that hexokinase 2 could be SUMOylated at K315 and K492.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that stomatin expression was markedly upregulated by the interaction between prostate cancer cells and stromal cells.
[Cancer Research] |
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| The authors report that the androgen receptor promoted glutaminase 1 expression and glutamine utilization to support the survival of prostate cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers demonstrated that epithelial–mesenchymal transition in prostate tumors was promoted by obesity and suppressed upon pharmacological adipose stromal cells depletion in HiMyc mice, a spontaneous genetic model of prostate cancer.
[npj Precision Oncology] |
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In vitro, kinesin family member 18B (KIF18B) knockdown in prostate cancer cell lines promoted cell proliferation, migration, and invasion, and inhibited cell apoptosis, while KIF18B overexpression had the opposite effects.
[Cell Death & Disease] |
| | Scientists investigated the action of fibroblast growth factor 21 (FGF21) in the development of prostate cancer (PCa). They found that FGF21 expression was markedly downregulated in PCa tissues and cell lines.
[Cell Death & Disease] |
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| Researchers report that lncRNA Prostate cancer antigen 3 (PCA3) played a role in prostate cancer progression that was mediated by nucleoplasmic lamins.
[Cancer Gene Therapy] |
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| The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.
[Prostate Cancer and Prostatic Diseases] |
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| Investigators showed that Pin1 interacted with the androgen receptor (AR) N-terminal domain. The inhibition of Pin1 expression or its activity selectively reduced the transcriptional activities of full-length AR and AR- splice variant 7.
[Communications Biology] |
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| Scientists demonstrated that enhancer of zeste homolog-2 (EZH2) inhibition in prostate cancer models activated a double-stranded RNA–STING–ISG stress response upregulating genes involved in antigen presentation, Th1 chemokine signaling, and interferon response, including programmed cell death protein 1 (PD-L1) that was dependent on STING activation.
[Nature Cancer] |
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| Investigators designed a novel computed tomography (CT)–SPRT technique to deliver a single high-dose 25 Gy fraction of X-ray radiation.
[Scientific Reports] |
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| Ongoing research to establish predictive biomarkers for the treatment of tumors with resistance to second-generation androgen receptor antagonists led to the approval of the PARP inhibitors olaparib and rucaparib in pre-treated metastatic castration-resistant prostate cancer.
[Nature Reviews Urology] |
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| Myovant Sciences announced the four recipients of its Forward for Health Equity grants. The grant program provides funding to nonprofit healthcare organizations with innovative projects focused on improving healthcare access, with an initial focus on reducing racial disparities in prostate cancer and uterine fibroids in the US.
[Myovant Sciences] |
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| Bio-Techne Corporation announced that Exosome Diagnostics, a Bio-Techne brand, has completed its clinical validation of an in vitro diagnostic (IVD) version of the ExoDx™ Prostate test kit enabling self-certification as CE-IVD.
[Bio-Techne Corporation] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | Duke University – Durham, North Carolina, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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