| CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression Researchers show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate. [Cancer Cell] A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression Researchers show that KLHL20, a Cullin3 substrate adaptor induced by hypoxia-inducible factor 1 (HIF-1), coordinates with the actions of CDK1/2 and Pin1 to mediate hypoxia-induced promyelocytic leukemia (PML) proteasomal degradation. [Cancer Cell] Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis The main objective of the present study was to identify microRNA genes that regulate metastatic prostate cancer. [Clin Cancer Res] ADAM17 Regulates Prostate Cancer Cell Proliferation through Mediating Cell Cycle Progression by EGFR/PI3K/AKT Pathway In the present study, researchers evaluated the effects of a disintegrin and metalloprotease 17 (ADAM17) on the proliferation and on the cell cycle distribution of human prostate cancer cells. [Mol Cell Biochem] Dietary Vitamin D (VD) and Vitamin D Receptor (VDR) Level Modulate Epithelial Cell Proliferation and Apoptosis in the Prostate Researchers tested whether low VD status or VDR deletion influences prostate epithelial cell biology using intact mice, castrated mice, or castrated mice treated with testosterone propionate. [Cancer Prev Res] Galiellalactone Inhibits Stem Cell-Like Aldehyde Dehydrogenase-Positive Prostate Cancer Cells In this study researchers aimed to investigate the effect of galiellalactone on prostate cancer stem cell-like cells. [PLoS One] Genetic Variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF Genes Are Prognostic Markers of Prostate Cancer-Specific Mortality The purpose of this study was to test whether variation in selected candidate genes in biological pathways of interest for prostate cancer progression could help distinguish patients at higher risk for fatal prostate cancer. [Cancer Epidemiol Biomarkers Prev] The Interleukin 6 Receptor is a Direct Transcriptional Target of E2F3 in Prostate Tumor Derived Cells The goal of this study was to identify direct transcriptional targets of E2F3 in prostate tumor derived cells. [Prostate] Tasquinimod Prevents the Angiogenic Rebound Induced by Fractionated Radiation Resulting in an Enhanced Therapeutic Response of Prostate Cancer Xenografts Human endothelial and prostate cancer cells in culture and human prostate cancer xenografts growing in castrated male nude mice were evaluated for their response to radiation alone and in combination with tasquinimod. [Prostate] Expression of LDL-A Module of Relaxin Receptor in Prostate Cancer Cells Inhibits Tumorigenesis In this study, researchers investigated the effect of low density lipoprotein A (LDL-A) overexpression on prostate cancer cells. [Int J Oncol] CLINICAL RESEARCH Dual EGFR/HER2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Withdrawal by Suppressing ErbB3 The overall goal of this study is to determine whether dual inhibition of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) would prolong the effectiveness of androgen withdrawal therapy in prostate cancer. [Clin Cancer Res] Low Testosterone Bioavailability is Related to Prostate Cancer Diagnoses in Patients Submitted to Prostate Biopsy The aim of this study was to determine the relationship between hormone levels and the diagnosis of prostate cancer. [World J Urol] |
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