| PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH Androgen Deprivation Causes Epithelial-Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy Here, researchers demonstrate that both normal mouse prostate tissue and human LuCaP35 prostate tumor explants display an epithelial-mesenchymal transition as well as increased stem cell-like features following androgen deprivation. [Cancer Res] Abstract Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti-CTLA-4 Therapy In this study, researchers offer a preclinical proof of concept in the TRAMP-C2 mouse model of prostate cancer that CTLA-4 blockade cooperates with cryoablation of a primary tumor to prevent the outgrowth of secondary tumors seeded by challenge at a distant site. [Cancer Res] Abstract Lipid Nanoparticle siRNA Systems for Silencing the Androgen Receptor in Human Prostate Cancer In Vivo In this study researchers investigated the ability of lipid nanoparticle (LNP) formulations of small interfering RNA (siRNA) to silence androgen receptor in human prostate tumor cell lines in vitro and in LNCaP xenograft tumors following intravenous injection. [Int J Cancer] Abstract p65-Dependent Production of Interleukin-1β by Osteolytic Prostate Cancer Cells Causes an Induction of Chemokine Expression in Osteoblasts Treatment of primary murine osteoblasts with conditioned medium of the human osteolytic prostate cancer cell line PC-3 results in a rapid induction of chemokine expression, thereby providing evidence for a molecular crosstalk between bone and tumor cells. The aim of this current study was to identify PC-3-derived molecules mediating this effect. [Cancer Lett] Abstract Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases The aim of this study was to develop an approach to assess the prevalence and function of androgen receptor variants in prostate cancer. [PLoS One] Abstract LIV-1 Promotes Prostate Cancer Epithelial-to-Mesenchymal Transition and Metastasis through Heparin Binding-Epidermal Growth Factor Shedding and Epidermal Growth Factor Receptor-Mediated Extracellular Signal Regulated Kinase Signaling Researchers characterized the mechanism by which LIV-1 drives human prostate cancer epithelial-to-mesenchymal transition in an androgen-refractory prostate cancer cells prostate cancer bone metastasis model. [PLoS One] Abstract Activation of c-MET Induces a Stem-Like Phenotype in Human Prostate Cancer The objective of this study was to determine the role of immature cells in prostate cancer by analysis of the hepatocyte growth factor/c-MET pathway. [PLoS One] Abstract A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer In the present study, researchers established the constitutive expression of perforin and granzyme B by the PC-3 and DU145 prostate cancer cell lines with RT-PCR, IHC and/or Western blot. [J Androl] Abstract CLINICAL RESEARCH Circulating Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins (IGFBPs) in PSA-Detected Prostate Cancer: The Large Case Control Study ProtecT Here scientists report the findings of a United Kingdom-based case-control study to investigate circulating IGFs and IGFBPs in prostate-specific antigen (PSA)-detected prostate cancer with regard to their potential associations with different cancer stages or grades. [Cancer Res] Abstract Genetic Variation in Nucleotide Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk Researchers evaluated interactions between pesticide exposure and 324 single nucleotide polymorphisms tagging 27 nucleotide excision repair genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of white Agricultural Health Study pesticide applicators. [Carcinogenesis] Abstract Matched Cohort Analysis of Outcomes of Definitive Radiotherapy for Prostate Cancer in Human Immunodeficiency Virus-Positive Patients The purpose of this study was to compare the biochemical outcome and toxicity scores of men with human immunodeficiency virus (HIV) and prostate cancer with a matched control population with negative or unknown HIV status when treated with external-beam radiotherapy. [Int J Radiat Oncol Biol Phys] Abstract Spurious Elevation of Serum PSA after Curative Treatment for Prostate Cancer: Clinical Consequences and the Role of Heterophilic Antibodies The aim of this study was to determine the prevalence of small, spurious PSA elevations, and the role of heterophilic antibodies. [Prostate Cancer Prostatic Dis] Abstract |
| SCIENCE NEWS | Preliminary Data Demonstrate that 40 mg Daily Dose of Cabozantinib Yields a High Rate of Bone Scan Response in mCRPC Exelixis, Inc. reported data from two ongoing clinical trials exploring lower starting doses of cabozantinib in cancer patients, including a phase I investigator-sponsored trial designed to assess the lowest effective dose of cabozantinib for treatment of metastatic bone lesions in patients with metastatic castration-resistant prostate cancer (mCRPC) as assessed by post-treatment changes in bone scans. [Press release from Exelixis, Inc. discussing research presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, San Francisco] Press Release |
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