LABORATORY RESEARCH Common Structural and Epigenetic Changes in the Genome of Castration Resistant Prostate Cancer In this study, scientists investigated gene copy number and CpG methylation status in castration-resistant prostate cancer to gain insight into specific pathophysiological pathways that are active in this advanced form of prostate cancer. [Cancer Res] Abstract Modeling Lethal Prostate Cancer Variant with Small Cell Carcinoma Features Researchers developed a set of CRPC xenografts and examined their fidelity to their human tumors of origin. [Clin Cancer Res] Abstract Differentiation of Prostate Cancer Cells by Using Flexible Fluorescent Polymers By using a step-wise linear discriminant analysis, researchers demonstrate that the differential modulations of the polymer emission intensities in the presence of conditioned cell culture media can be used to distinguish between prostate cancer subtypes and between cancerous and non-cancer cells. [Anal Chem] Abstract Effect of Dietary Polyunsaturated Fatty Acids on Castration-Resistant Pten-Null Prostate Cancer In the present study, researchers sought to determine whether dietary polyunsaturated fatty acid affects the development of castration-resistant prostate cancer. [Carcinogenesis] Abstract α-Mangostin, a Xanthone from Mangosteen Fruit, Promotes Cell Cycle Arrest in Prostate Cancer and Decreases Xenograft Tumor Growth Researchers examined the anti-cancer effect of α-mangostin in human prostate cancer cells and its role in targeting cell cycle related proteins involved in prostate carcinogenesis. [Carcinogenesis] Abstract Biochemical Relapse following Radical Prostatectomy and miR-200a Levels in Prostate Cancer A pair of cancer and normal prostate cell lines derived from the same radical prostatectomy specimen were transfected with miR-200a to determine the effects on growth, wound healing, and invasion. [Prostate] Abstract Double-Targeted and Double-Enhanced Suicide Gene Therapy Mediated by Generation 5 Polyamidoamine Dendrimers for Prostate Cancer In this study, researchers established a novel system using nonviral gene vector generation 5 polyamidoamine dendrimer to express herpes simplex virus-thymidine kinase and connexin43 gene driven by prostate-specific membrane antigen promoter, and evaluated the anti-tumor effect of this system. [Mol Carcinog] Abstract Human Prostate Cancer ZIP1/Zinc/Citrate Genetic/Metabolic Relationship in the TRAMP Prostate Cancer Animal Model This is the first report that establishes the existence of the human prostate zinc/citrate hallmark characteristic and relationship in an animal model. [Cancer Biol Ther] Abstract CLINICAL RESEARCH Identifying the Best Candidate for Radical Prostatectomy Among Patients with High-Risk Prostate Cancer In this study, researchers’ objective was to identify which high-risk prostate cancer patients might have favorable pathologic outcomes when surgically treated. [Eur Urol] Abstract 180-W XPS GreenLight Laser Therapy for Benign Prostate Hyperplasia: Early Safety, Efficacy, and Perioperative Outcome After 201 Procedures The objective of this study was to evaluate the prevalence of perioperative complications and short-term outcome for the first time with the XPS laser in men with lower urinary tract symptoms due to benign prostatic enlargement. [Eur Urol] Abstract Early Changes in Apparent Diffusion Coefficient from Diffusion-Weighted MR Imaging During Radiotherapy for Prostate Cancer The purpose of this study was to investigate the feasibility of diffusion-weighted MRI as an early and reproducible change indicator in patients receiving radiotherapy for prostate cancer. [Int J Radiat Oncol Biol Phys] Abstract Association of 5α-Reductase Inhibitor Use and Pathological Features of Prostate Cancer in Men Undergoing Radical Prostatectomy Researchers investigated the association of 5α-reductase inhibitor treatment with pathologic and biochemical outcome among the contemporary prostate cancer patients undergoing radical prostatectomy. [Prostate] Abstract |