LABORATORY RESEARCH Increased CD8+ T Cell Function following Castration and Immunization Is Countered by Parallel Expansion of Regulatory T Cells In the prostate-specific Pten-/- mouse model of prostate cancer, researchers observed an accelerated regulatory T cells expansion in mice bearing the castration-resistant endogenous prostate tumor, which prevented effector responses to UV-8101-RE. [Cancer Res] Abstract RhoB Regulates uPAR Signaling Here, researchers used RNAi to screen 12 different Rho GTPases for effects on uPA-stimulated migration, and found that depletion of RhoB significantly reduces uPA-induced migration and invasion of prostate carcinoma cells. [J Cell Sci] Abstract Saquinavir-NO-Targeted S6 Protein Mediates Sensitivity of Androgen-Dependent Prostate Cancer Cells to TRAIL In this study, researchers evaluated the effects of Saquinavir-NO on androgen-dependent prostate cancer LNCaP. [Cell Cycle] Abstract Androgen Deprivation Causes Truncation of the C-Terminal Region of Androgen Receptor in Human Prostate Cancer LNCaP Cells In the present study, researchers report that the C-terminal truncated androgen receptor (AR), which they named the N-terminal fragment of AR cleaved in the neighborhood of helix 1 of the ligand-binding domain, is produced in LNCaP prostatic carcinoma cells. [Cancer Sci] Abstract Trop-2 Inhibits Prostate Cancer Cell Adhesion to Fibronectin through the β1 Integrin-RACK1 Axis Here, researchers show for the first time that Trop-2’s expression in prostate cancer cells correlates with their aggressiveness. [J Cell Physiol] Abstract PDEF Downregulates Stathmin Expression in Prostate Cancer Researchers’ results suggest that prostate-derived Ets transcription factor (PDEF) may inhibit prostate cancer progression by transcriptional downregulation of oncogenic stathmin expression. [Int J Oncol] Abstract Effect of the Heat Shock Protein HSP27 on Androgen Receptor Expression and Function in Prostate Cancer Cells In order to study the functional relationship between heat shock protein 27 (HSP27) and the androgen receptor, researchers modulated the expression of the small heat shock protein HSP27 in human prostate cancer cell lines. [World J Urol] Abstract Digoxin Inhibits Blood Vessel Density and Hypoxia-Inducible Factor 1a Expression in Castration-Resistant C4-2 Xenograft Prostate Tumors This study was designed to determine if digoxin can inhibit androgen receptor-positive xenograft prostate tumors. [Clin Transl Sci] Abstract CLINICAL RESEARCH Prostate-Specific Antigen Response to Deferred Combined Androgen Blockade Therapy Using Bicalutamide Predicts Survival after Subsequent Estrogen and Docetaxel Therapies in Patients with Castration-Resistant Prostate Cancer Researchers’ objective was to evaluate whether there is any association between prostate-specific antigen response to deferred combined androgen blockade therapy using bicalutamide in patients with castration-resistant prostate cancer, initially treated with castration monotherapy, and the clinical outcomes after subsequent oestrogen and docetaxel therapies. [BJU Int] Abstract Preoperative Characteristics of High-Gleason Disease Predictive of Favorable Pathological and Clinical Outcomes at Radical Prostatectomy The objective of this study was to investigate preoperative characteristics that distinguish favorable and unfavorable pathological and clinical outcomes in men with high biopsy Gleason sum prostate cancer to better select men who will most benefit from radical prostatectomy. [BJU Int] Abstract |