| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Inhibition Kinetics and Regulation of Sphingosine Kinase 1 Expression in Prostate Cancer Cells: Functional Differences between Sphingosine Kinase 1a and 1b Scientists demonstrated that 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole, FTY720, and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 activity with distinct kinetics, indicating that these compounds exhibit different binding modalities with sphingosine kinase 1. [Int J Biochem Cell Biol] Abstract Cyclosporin A Suppresses Prostate Cancer Cell Growth through Ca2+/Calmodulin-Dependent Protein Kinase Kinase β/AMPK-Mediated Inhibition of mTOR Complex 1 Signaling Researchers showed that AMP-activated protein kinase (AMPK) mediates the antitumor effect of cyclosporin A on prostate cancer cells. [Biochem Pharmacol] Abstract The Use of LC-MS to Identify Differentially Expressed Proteins in Docetaxel-Resistant Prostate Cancer Cell Lines To identify proteins altered in the docetaxel-resistant phenotype, three parental cell lines DU145, 22RV1 and PC-3, as well as their docetaxel resistant sub-lines, were subjected to quantitative label-free LC-MS proteomic profiling. [Proteomics] Abstract Sulforaphane, a Cruciferous Vegetable-Derived Isothiocyanate, Inhibits Protein Synthesis in Human Prostate Cancer Cells Scientists showed that sulforaphane inhibits protein synthesis in PC-3 cells in a dose- and time-dependent manner which is accompanied by a decreased phosphorylation of mTOR substrates. [Biochim Biophys Acta] Abstract Combined Immunotherapy with Listeria monocytogenes-Based PSA Vaccine and Radiation Therapy Leads to a Therapeutic Response in a Murine Model of Prostate Cancer Investigators evaluated the combination of radiation therapy and immunotherapy using L. monocytogenes-based vaccine in a mouse model of prostate cancer. [Cancer Immunol Immunother] Abstract Constitutively Active c-Met Kinase in PC-3 Cells Is Autocrine-Independent and Can Be Blocked by the Met Kinase Inhibitor BMS-777607 Scientists examined the response of PC-3 cells to an anti-hepatocyte growth factor neutralizing antibody or a small molecule Met kinase inhibitor (BMS-777607). [BMC Cancer] Abstract | Full Article Identification of a Potential Tumor Differentiation Factor Receptor Candidate in Prostate Cancer Cells Scientists investigated whether tumor differentiation factor receptor candidates from prostate cancer cells are the same as those identified in breast cancer cells. [FEBS J] Abstract | Press Release Human Bone Marrow-Derived Mesenchymal Stem Cells Produced TGFbeta Contributes to Progression and Metastasis of Prostate Cancer Researchers observed that human mesenchymal stem cells promoted human prostate cancer cell PC-3 growth in vivo and in vitro. [Cancer Invest] Abstract CLINICAL RESEARCH Responder Analysis of the Effects of Denosumab on Bone Mineral Density in Men Receiving Androgen Deprivation Therapy for Prostate Cancer Men with nonmetastatic prostate cancer receiving androgen deprivation therapy were treated with subcutaneous denosumab 60 mg or placebo every six months for up to 36 months in a phase III, randomized, double-blind study. [Prostate Cancer Prostatic Dis] Abstract A Randomized Trial of Robotic and Open Prostatectomy in Men with Localized Prostate Cancer Researchers present the design of a randomized trial of robotic and open prostatectomy for men newly diagnosed with localized prostate cancer. [BMC Cancer] Abstract | Full Article
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| JOB OPPORTUNITIES | Research Associate – Chemistry (STEMCELL Technologies, Inc.) Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.) Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.) Research Technologist – Media Development (STEMCELL Technologies, Inc.) Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.) Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.) Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.) Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.) Business Analyst – Product Management (STEMSOFT Software, Inc.) Associate Research Scientist (Columbia University Medical Center) Clinical Research Associate (Jennerex Biotherapeutics, Inc.) Research Associate – Development (Precision Therapeutics, Inc.) Postdoctoral Fellow – Prostate Research (Baylor College of Medicine) Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost. |
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