| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH 14-3-3ζ, a Novel Androgen-Responsive Gene, Is Upregulated in Prostate Cancer and Promotes Prostate Cancer Cell Proliferation and Survival Scientists investigated the androgen regulation and functional analysis of 14-3-3ζ in prostate cancer. [Clin Cancer Res] Abstract Regulation of Expression of Deoxyhypusine Hydroxylase (DOHH), the Enzyme that Catalyzes the Activation of eIF5A, by miR-331-3p and miR-642-5p in Prostate Cancer Cells Researchers discovered a novel role for miR 331-3p and miR 642 5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eukaryotic translation initiation factor (eIF5A) activity. [J Biol Chem] Full Article Diverse Functions of IGF/Insulin Signaling in Malignant and Noncancerous Prostate Cells: Proliferation in Cancer Cells and Differentiation in Noncancerous Cells Investigators stimulated prostate cancer and noncancerous prostate cells and observed differing responses: while cancer cells responded to insulin-like growth factor (IGF) and insulin exposure by way of enhanced cell proliferation and glucose consumption, basal to luminal differentiation was induced in noncancerous cells. [Endocrinology] Abstract A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo Researchers found that treatment with doxazosin triggered EphA2 receptor internalization, and suppressed haptotactic and chemotactic migration of prostate cancer, breast cancer, and glioma cells. [PLoS One] Full Article Androgen Deprivation Induces Senescence Characteristics in Prostate Cancer Cells In Vitro and In Vivo Scientists investigated the occurrence of senescence in prostate tumor tissue after androgen deprivation therapy. [Prostate] Abstract Inflammation-Mediated Abrogation of Androgen Signaling: An In Vitro Model of Prostate Cell Inflammation Scientists established an in vitro model of prostatic inflammation to investigate the loss of androgen receptor-mediated signaling in androgen responsive prostate cell lines. [Mol Carcinogen] Abstract Does Androgen-Ablation Therapy (AAT) Associated Autophagy Have a Pro-Survival Effect in LNCaP Human Prostate Cancer Cells? Researchers studied the cellular effects of the anti-androgen bicalutamide on autophagy and its potential impact on response to androgen-ablation therapy alone or combined with docetaxel chemotherapy in human prostate cancer LNCaP cells. [BJU Int] Abstract Knockdown of Zinc Finger Protein X-Linked Inhibits Prostate Cancer Cell Proliferation and Induces Apoptosis by Activating Caspase-3 and Caspase-9 Scientists found that repression of zinc finger protein X-linked (ZFX) in prostate cancer cells effectively suppressed the cellular proliferation and colony-formation ability, and led to G1 phase cell cycle arrest. Inhibition of ZFX-induced cell apoptosis by activating caspase-1, -3 and -9. [Cancer Gene Ther] Abstract CLINICAL RESEARCH Cell-Free Circulating Plasma hTERT mRNA Is a Useful Marker for Prostate Cancer Diagnosis and Is Associated with Poor Prognosis Tumor Characteristics Researchers assessed the usefulness of plasma telomerase reverse transcriptase (hTERT) mRNA as a diagnostic and prognostic tool for prostate cancer and its association with clinicopathological parameters of tumors. [PLoS One] Full Article Phase II Study of Carlumab, a Human Monoclonal Antibody Against CC-Chemokine Ligand 2, in Metastatic Castration-Resistant Prostate Cancer. In this phase II, open-label study, patients with metastatic castration-resistant prostate cancer previously treated with docetaxel received a 90-min infusion of 15 mg/kg carlumab q2w. [Invest New Drugs] Abstract |
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