LABORATORY RESEARCH Inhibitors of Vacuolar ATPase Proton Pumps Inhibit Human Prostate Cancer Cell Invasion and Prostate-Specific Antigen Expression and Secretion Investigators studied the effects of inhibiting vacuolar ATPase pumps in androgen-dependent and androgen-independent cells of a human prostate cancer progression model. [Int J Cancer] Abstract Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells Scientists explored the expression profile and functional activity of peptide transporters in the prostate cancer cell lines LNCaP, PC-3 and DU145. [Mol Pharm] Abstract Proteomic Exploration of the Impacts of Pomegranate Fruit Juice on the Global Gene Expression of Prostate Cancer Cells Investigators demonstrated that pomegranate fruit juice could effectively hinder the proliferation of human prostate cancer DU145 cells. [Proteomics] Abstract Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells Researchers investigated whether copper might regulate the ectodomain shedding of two key cell surface proteins implicated in the invasion and metastasis of prostate cancer and whether the metal was able to influence the invasion of the prostate cancer epithelial cell line PC3. [Mol Cancer Res] Abstract Protein Arginine Methyltransferase 5 Functions in Opposite Ways in the Cytoplasm and Nucleus of Prostate Cancer Cells Researchers demonstrated that protein arginine methyltransferase 5 is predominantly localized in the cytoplasm of prostate cancer cells. [PLoS One] Full Article Xanthohumol Impairs Human Prostate Cancer Cell Growth and Invasion, and Diminishes the Incidence and Progression of Advanced Tumors in TRAMP Mice Investigators used human hormone-resistant prostate cancer cells as an in vitro model to assess the efficacy of xanthohumol against cell growth, motility and invasion. [Mol Med] Full Article Treatment with the MEK Inhibitor U0126 Induces Decreased Hyperpolarized Pyruvate to Lactate Conversion in Breast, but Not Prostate, Cancer cells Scientists monitored the effect of treatment with the mitogen-activated protein kinase (MEK) inhibitor U0126 in prostate and breast cancer cells. [NMR Biomed] Abstract The Anticancer Effects of Saccharina japonica on 267B1/K-Ras Human Prostate Cancer Cells Researchers evaluated the potential anticancer effects of Saccharina japonica on 267B1/K-ras human prostate cancer cells. The exposure of cells to the extract induced inhibition of cell growth by increasing the number of apoptotic cells with cell shrinkage and inhibition of cell cycle progression. [Int J Oncol] Abstract Genome-Wide DNA Methylation Events in TMPRSS2:ERG Fusion Negative Prostate Cancers Implicate an EZH2 Dependent Mechanism with miRNA-26a Hypermethylation Scientists investigated genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using MeDIP-Seq. [Cancer Discovery] Abstract | Press Release CLINICAL RESEARCH High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Clinically Localized Prostate Cancer: Treatment Evolution and Mature Results Scientists report the clinical outcome of high-dose-rate interstitial brachytherapy as sole treatment for clinically localized prostate cancer. [Int J Radiat Oncol Biol Phys] Abstract Phase II Trial of RAD001 and Bicalutamide for Castration-Resistant Prostate Cancer Researchers determined the best overall response and duration of response of RAD001 in combination with bicalutamide in castration-resistant prostate cancer. [BJU Int] Abstract |