LABORATORY RESEARCH The Enzymatic Activity of Apoptosis Inducing Factor Supports Energy Metabolism Benefitting the Growth and Invasiveness of Advanced Prostate Cancer Cells Researchers explored the contribution of apoptosis inducing factor (AIF) to the progression of prostate cancer. Analysis of archival gene expression data demonstrated that AIF transcript levels are elevated in human prostate cancer, and the researchers found that AIF protein is increased in prostate tumors. [J Biol Chem] Abstract P21-Activated Kinase 6 (PAK6) Inhibits Prostate Cancer Growth via Phosphorylation of Androgen Receptor and Tumorigenic E3 Ligase Murine Double Minute-2 (Mdm2) Regulation of androgen receptor (AR) homeostasis in prostate tumorigenesis has not yet been fully characterized. Investigators demonstrated that p21-activated kinase 6 inhibits prostate tumorigenesis by regulating AR homeostasis. [J Biol Chem] Abstract Genetic Ablation of the Tetraspanin Cd151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model Scientists showed that genetic ablation of CD151 inhibits spontaneous metastasis in a transgenic mouse model of de novo tumorigenesis. To evaluate the effects of CD151 on de novo prostate cancer initiation and metastasis, a Cd151-/- murine model was crossed with the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model. [Mol Cancer Res] Abstract Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer Researchers assessed whether risk of prostate cancer is affected by genetic variants in genes coding for selenoproteins, either alone or in combination with Selenium status. [PLoS One] Full Article Midkine Is Associated with Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer Expression of growth factor midkine (MDK) is correlated with poor clinical outcomes in various human cancers, including prostate cancer (PC). Scientists evaluated MDK expression and neuroendocrine differentiation in two separate tumor groups: early and advanced PC. [Prostate] Abstract PCA3 Noncoding RNA Is Involved in the Control of Prostate-Cancer Cell Survival and Modulates Androgen Receptor Signaling To investigate putative function of PCA3 in prostate cancer biology, investigators used gene expression knockdown by small interference RNA and also analyzed its involvement in androgen receptor signaling. [BMC Cancer] Abstract | Full Article Association of Legumain Expression Pattern with Prostate Cancer Invasiveness and Aggressiveness Researchers investigated the clinical implication of legumain, an asparaginyl endopeptidase that is highly expressed in several types of cancer, expression in prostate cancer. [World J Urol] Abstract | Full Article CLINICAL RESEARCH Selenoprotein P Genetic Variants and mRNA Expression, Circulating Selenium, and Prostate Cancer Risk and Survival Researchers utilized a nested case-control study of 1,352 prostate cancer cases and 1,382 controls. They assessed four single nucleotide polymorphisms capturing common variation within the selenoprotein P (SEPP1) locus. In a subset of men, they evaluated SEPP1 mRNA expression in tumors. [Prostate] Abstract HOXB13 Mutations in a Population-Based, Case-Control Study of Prostate Cancer Investigators determined the distribution and frequency of the G84E HOXB13 variant in 1,310 incipient prostate cancer (PC) cases and 1,259 age-mated controls from a population-based, case-control study of PC. [Prostate] Abstract |