LABORATORY RESEARCH Metabolic Intervention on Lipid Synthesis Converging Pathways Abrogates Prostate Cancer Growth One of the most conserved features of all cancers is a profound reprogramming of cellular metabolism, favoring biosynthetic processes and limiting catalytic processes. With the acquired knowledge of some of these important changes, researchers have designed a combination therapy in order to force cancer cells to use a particular metabolic pathway that ultimately results in the accumulation of toxic products. [Oncogene] Full Article A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells The authors synthesized and chemically characterized a novel, semisynthetic triterpenoid derivative, 3-cinnamoyl-11-keto-β-boswellic acid. Its pharmacodynamic effects on mammalian target of rapamycin and several other signaling pathways were assessed in a number of prostate and breast cancer cell lines as well as in normal prostate epithelial cells. [Mol Pharmacol] Abstract Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells Researchers report that the attenuation of cathepsin H aminopeptidase activity by specific inhibitor or siRNA-mediated silencing significantly reduced the migration of metastatic PC-3 prostate cells on fibronectin, as well as the invasion through Matrigel. [J Biol Chem] Abstract Prostaglandin 15d-PGJ2 Inhibits Androgen Receptor Signaling in Prostate Cancer Cells Investigators showed that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenously produced antiinflammatory prostaglandin, targets the androgen receptor (AR) and acts as a potent AR inhibitor, rapidly repressing AR target genes, such as FKBP51 and TMPRSS2 in prostate cancer cells. [Mol Endocrinol] Abstract ARHGAP21 Is a RhoGAP for RhoA and RhoC with a Role in Proliferation and Migration of Prostate Adenocarcinoma Cells ARHGAP21 is a Rho GTPase-activating proteins (RhoGAP) with increased expression in head and neck squamous cell carcinoma and with a possible role in glioblastoma tumor progression, yet little is known about the function of ARHGAP21 in cancer cells. Scientists studied the role of ARHGAP21 in two prostate adenocarcinoma cell lines, LNCaP and PC3, which respectively represent initial and advanced stages of prostate carcinogenesis. [Biochim Biophys Acta] Abstract Modeling Truncated AR Expression in a Natural Androgen Responsive Environment and Identification of RHOB as a Direct Transcriptional Target Researchers present a model system in which a C-terminally truncated variant of androgen receptor (TC-AR) is inducibly expressed in LNCaP, an androgen-dependent cell line, which expresses little truncated receptor. They observed that when TC-AR is overexpressed, the endogenous full length receptor is transcriptionally downmodulated. [PLoS One] Full Article Purple Corn Color Inhibition of Prostate Carcinogenesis by Targeting Cell Growth Pathways Purple corn color is a widely used food colorant that was reported to have attenuating effects on hypertension, diabetes, and to have anti-cancer effects on colon and breast cancer. This is the first study on its possible chemoprevention effects against prostate cancer. For this purpose an androgen-dependent prostate cancer cell line, LNCaP, was used to examine effects in vitro. [Cancer Sci] Abstract Acquisition of Paclitaxel Resistance Is Associated with a More Aggressive and Invasive Phenotype in Prostate Cancer The authors established paclitaxel resistance in a classic, androgen-insensitive mCRPC cell line and, using a suite of molecular and biophysical methods, characterized the structural and functional changes in vitro and in vivo that are associated with the development of drug resistance. [J Cell Biochem] Abstract CLINICAL RESEARCH Cellular Immunotherapy Study of Prostate Cancer Patients and Resulting IgG Responses to Peptide Epitopes Predicted from Prostate Tumor-Associated Autoantigens In this dose escalation Phase I study, researchers report safety, feasibility, and immunologic data of an immunotherapy composed of two human prostate cancer cell lines engineered to express α1,3galactosyl epitopes. [J Immunother] Abstract Multicenter Experience with Robot-Assisted Radical Prostatectomy in Renal Transplant Recipients Researchers aimed to evaluate their multi-institutional outcome with robot-assisted radical prostatectomy in renal transplant recipients and describe technical modifications of the procedure. [Urology] Abstract |