LABORATORY RESEARCH Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer Through Loss of ABCA1 By performing next-generation sequencing-based DNA methylome analysis, scientists discovered marked hypermethylation at the promoter of the major cellular cholesterol efflux transporter, ABCA1, in LNCaP prostate cancer cells. ABCA1 promoter hypermethylation renders the promoter unresponsive to trans-activation and leads to elevated cholesterol levels in LNCaP. [Cancer Res] Abstract Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression Investigators examined primary and metastatic prostate cancer and found that miR-31 expression was reduced as a result of promoter hypermethylation and importantly, the levels of miR-31 expression were inversely correlated with the aggressiveness of the disease. [Cancer Res] Abstract Role of OGR1 in Myeloid-Derived Cells in Prostate Cancer Researchers demonstrated that ovarian cancer G-protein-coupled-receptor-1 (OGR1) deficiency in host cells significantly reduced tumorigenesis of prostate cancer in mice. [Oncogene] Abstract New Therapeutic Approach to Suppress Castration-Resistant Prostate Cancer Using ASC-J9 via Targeting Androgen Receptor in Selective Prostate Cells Using androgen receptor (AR) knockout mice to determine AR functions in selective prostate cancer (PCa) cells, the authors determined that AR might play differential roles in various cell types, either to promote or suppress PCa development/progression. [Am J Pathol] Abstract Loss of LARGE2 Disrupts Functional Glycosylation of α-Dystroglycan in Prostate Cancer Scientists showed that the level of expression of the β-dystroglycan (βDG) subunit as well as the glycosylation status of the αDG subunit inversely correlate with the Gleason scores of prostate cancers; furthermore, they showed that the functional glycosylation of αDG is substantially reduced in prostate cancer metastases. [J Biol Chem] Abstract Akt Mediates Metastasis-Associated Gene 1 (MTA1) Regulating the Expression of E-Cadherin and Promoting the Invasiveness of Prostate Cancer Cells Scientists demonstrated that the silencing of MTA1 by siRNA treatment results in the upregulation of E-cadherin expression by the phosphorylation of AKT and decreases the invasiveness of prostate cancer cells. [PLoS One] Full Article δ-Catenin Overexpression Promotes Angiogenic Potential of CWR22Rv-1 Prostate Cancer Cells via HIF-1α and VEGF The authors revealed that CWR22Rv-1 cells overexpressing δ-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. [FEBS Lett] Abstract Temperature-Dependent Activation of Differential Apoptotic Pathways during Cryoablation in a Human Prostate Cancer Model A human prostate cancer model and cells were exposed to temperatures of -60, -30 and -15 °C to simulate a cryoablative procedure. Using a combination of flow-cytometry, fluorescent microscopy and western blot analyses, samples were assessed at various times post thaw to identify the presence, levels and the pathways involved in cell death. [Prostate Cancer Prostatic Dis] Abstract CLINICAL RESEARCH Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy In this double-blind study, researchers randomly assigned 1088 patients to receive abiraterone acetate (1000 mg) plus prednisone (5 mg twice daily) or placebo plus prednisone. The coprimary end points were radiographic progression-free survival and overall survival. [N Engl J Med] Abstract | Press Release Multicenter Evaluation of [-2]Proprostate-Specific Antigen and the Prostate Health Index for Detecting Prostate Cancer The prostate health index, a measure based on [-2]proprostate-specific antigen (p2PSA) and calculated as p2PSA/free PSA √total PSA, was evaluated in a multicenter study for detecting prostate cancer. [Clin Chem] Abstract |