LABORATORY RESEARCH Long Pentraxin-3 as an Epithelial-Stromal Fibroblast Growth Factor-Targeting Inhibitor in Prostate Cancer Researchers demonstrated that recombinant pentraxin-3 (PTX3) protein and the PTX3-derived pentapeptide Ac-ARPCA-NH2 abolishes the mitogenic response of murine TRAMP-C2 cells and human LNCaP prostate cancer cells to dihydrotestosterone and fibroblast growth factors. [J Pathol] Abstract Tumor Cell Survival Mechanisms in Lethal Metastatic Prostate Cancer Differ Between Bone and Soft Tissue Metastases To obtain a comprehensive picture of tumor cell survival in prostate cancer metastases, the authors interrogated five survival proteins that operate within three survival pathways in a cohort of 185 lethal metastatic prostate metastases obtained from 44 patients. [J Pathol] Abstract Sulforaphane Enhances Nrf2 Expression in Prostate Cancer TRAMP C1 Cells through Epigenetic Regulation Sulforaphane (SFN) in cruciferous vegetables has been demonstrated to be a potent cancer prevention agent for years. Researchers investigated the potential of SFN to restore Nrf2 expression in TRAMP C1 cells through epigenetic modifications. [Biochem Pharmacol] Abstract Human Chorionic Gonadotropin β Induces Migration and Invasion via Activating ERK1/2 and MMP-2 in Human Prostate Cancer DU145 Cells The authors previously demonstrated that human chorionic gonadotropin β (hCGβ) induced migration and invasion in human prostate cancer cells. However, the involved molecular mechanisms are unclear. In this study, they established a stable prostate cancer cell line overexpressing hCGβ and tested hCGβ-triggered signaling pathways causing cell migration and invasion. [PLoS One] Full Article Exon-Skipping Strategy by Ratio Modulation between Cytoprotective versus Pro-Apoptotic Clusterin Forms Increased Sensitivity of LNCaP to Cell Death In order to provide new therapeutic approaches targeting clusterin, researchers developed a strategy based on exon skipping by using a lentiviral construct to preferentially induce the nuclear spliced form of the protein. The molecular construct was transduced in LNCaP cells for testing the modulation of sensitivity of the transduced cells to pro-apoptotic stress. [PLoS One] Full Article Suppression of Dihydrotestosterone-Induced Paracrine Stimulation of Endothelial Cell Growth by Estrogens via Prostate Cancer Cells Scientists examined the paracrine stimulation of cell proliferation by prostate tumor cells and its modulation by androgen and estrogens in a murine endothelial cell line that does not express androgen receptor. [Prostate] Abstract The Phytoestrogenic Compound Cajanol from Pigeonpea Roots Is Associated with the Activation of Estrogen Receptor α-Dependent Signaling Pathway in Human Prostate Cancer Cells The main natural estrogen-agonist/antagonist from Pigeonpea roots was studied by the estrogen receptor α-dependent signaling pathway in human prostate cancer cells. [Phytother Res] Abstract CLINICAL RESEARCH Effects of Screening on Radical Prostatectomy Efficacy: The Prostate Cancer Intervention versus Observation Trial The authors assumed the Scandinavian Prostate Cancer Group Study Number 4 trial represents radical prostatectomy efficacy and prostate cancer survival in an unscreened population. Given the fraction of screen-detected prostate cancers in Prostate Cancer Intervention Versus Observation Trial, they adjusted prostate cancer survival using published estimates of overdiagnosis and lead time to project the effect of screen detection on disease-specific deaths. [J Natl Cancer Inst] Abstract | Press Release Phase II Clinical Trial of Cediranib in Patients with Metastatic Castration-Resistant Prostate Cancer Scientists assessed the efficacy and toxicity of cediranib, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy. [BJU Int] Abstract |