LABORATORY RESEARCH Polymerase I and Transcript Release Factor/Cavin-1 Neutralizes Non-Caveolar Caveolin-1 Microdomains in Prostate Cancer Utilizing PC-3 cells as a suitable model for caveolin-1-positive advanced prostate cancer, scientists found that cavin-1 expression in PC-3 cells inhibits anchorage-independent growth, and reduces in vivo tumor growth and metastasis in an orthotopic prostate cancer xenograft mouse model. [Oncogene] Abstract Marchantin M: A Novel Inhibitor of Proteasome Induces Autophagic Cell Death in Prostate Cancer Cells Scientists demonstrated that marchantin M potently inhibited chymotrypsin-like and peptidyl-glutamyl peptide-hydrolyzing activities of 20S proteasome both in in vitro and intracellular systems and significantly induced the accumulation of polyubiquitinated proteins in prostate cancer cells. [Cell Death Dis] Full Article Characterization of a New Class of Androgen Receptor Antagonists with Potential Therapeutic Application in Advanced Prostate Cancer Scientists report that VPC-3033 exhibited significant activity against prostate cancer cells that have already developed resistance to the second-generation antiandrogen Enzalutamide. [Mol Cancer Ther] Abstract Cyclin-Dependent Kinase 5 Modulates STAT3 and Androgen Receptor Activation through Phosphorylation of Ser727 on STAT3 in Prostate Cancer Cells Investigators showed that cyclin-dependent kinase 5 (Cdk5) biochemically interacts with STAT3 and this interaction depends on Cdk5 activation in prostate cancer cells. [Am J Physiol Endocrinol Metab] Abstract Differential Effects of Thapsigargin Analogues on Apoptosis of Prostate Cancer Cells: Complex Regulation by Intracellular Calcium Researchers evaluated on LNCaP androgen sensitive cancer cells the effect of thapsigargin substituted with 12-aminododecanoyl linkers and Leu, aspartate, or Boc-8ADT. [FEBS J] Abstract Activation of FGF2-FGFR Signaling in the Castrated Mouse Prostate Stimulates the Proliferation of Basal Epithelial Cells In organ culture experiments, basal epithelial proliferation was recapitulated in the absence of DHT. The proliferation of basal epithelial cells in the absence of DHT was suppressed by treatment with an FGF receptor inhibitor. [Biol Reprod] Abstract Hypoxia Preconditioning of Mesenchymal Stromal Cells Enhances PC3 Cell Lymphatic Metastasis Accompanied by VEGFR-3/CCR7 Signaling Activation Researchers investigated prostate cancer PC3 cell behavior under the influence of hypoxia preconditioned mesenchymal stromal cells and explored the related mechanism of prostate cancer lymphatic metastases in mice. [J Cell Biochem] Abstract Piperine Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Autophagy Researchers investigated the growth inhibitory effects of piperine on human prostate cancer DU145, PC-3 and LNCaP cells. Although piperine induced low levels of apoptosis, it promoted autophagy as evidenced by the increased level of LC3B-II and the formation of LC3B puncta in LNCaP and PC-3 cells. [Food Chem Toxicol] Abstract CLINICAL RESEARCH Long-Term Survival of Participants in the Prostate Cancer Prevention Trial In the Prostate Cancer Prevention Trial, finasteride significantly reduced the risk of prostate cancer but was associated with an increased risk of high-grade disease. With up to 18 years of follow-up, the authors analyzed rates of survival among all study participants and among those with prostate cancer. [N Engl J Med] Abstract | Press Release Metastasis-Free Survival Is Associated with Overall Survival in Men with PSA-Recurrent Prostate Cancer Treated with Deferred Androgen Deprivation Therapy This is a retrospective analysis of 450 men with biochemically recurrent prostate cancer (BRPC) following prostatectomy treated at a single institution between 1981 and 2010, of which 140 developed subsequent metastases. Median metastasis-free survival emerged as an independent predictor of overall survival in men with BRPC treated with deferred androgen deprivation therapy after the development of metastases. [Ann Oncol] Abstract |