Prostate Cell News Volume 4.38 | Oct 4 2013

Estrogen Receptor β Upregulates FOXO3a and Causes Induction of Apoptosis through PUMA in Prostate Cancer
In human prostate cancer cells, researchers found that estrogen receptor β causes apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apoptosis (PUMA), independent of p53, but dependent on the forkhead transcription factor class-O family member, FOXO3a. [Oncogene] Abstract

Increased Expression of CYP24A1 Correlates with Advanced Stages of Prostate Cancer and Can Cause Resistance to Vitamin D₃-Based Therapies
Scientists dissected the basis for the resistance to the vitamin D₃ antitumor properties and specifically examined the effect of its major catabolic enzyme, CYP24A1, in prostate cancer. The use of CYP24A1 RNAi enhanced the cytostatic effects of vitamin D₃ in human prostate cancer cells. [FASEB J] Abstract

Activation of the Wnt Pathway through Use of AR79, a Glycogen Synthase Kinase 3beta Inhibitor, Promotes Prostate Cancer Growth in Soft Tissue and Bone
Researchers determined if AR79 impacted progression of prostate cancer (PCa). AR79 inhibited beta-catenin phosphorylation, increased nuclear β-catenin accumulation in PCa and osteoblast cell lines and increased proliferation of PCa cells in vitro through beta-catenin. [Mol Cancer Res] Abstract

NSC126188 Induces Apoptosis of Prostate Cancer PC-3 Cells through Inhibition of Akt Membrane Translocation, FoxO3a Activation, and RhoB Transcription
Investigators showed that NSC126188 induces apoptosis of prostate cancer PC-3 cells by inhibiting Akt/FoxO3 signaling, which mediates RhoB upregulation. [Apoptosis] Abstract

Sodium Butyrate Induces Growth Inhibition and Apoptosis in Human Prostate Cancer DU145 Cells by Up-Regulation of the Expression of Annexin A1
Scientists investigated the mechanism of sodium butyrate action in prostate cancer DU145 cells. NaB significantly inhibited the growth and induction apoptosis of DU145 and PC3 cells in a dose-dependent manner. [PLoS One] Full Article

Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells
Researchers focused on the cell cycle regulatory potential of the withanolide withaferin A (1) on prostate cancer cells. Compound 1 induced G₂/M arrest in both prostate cancer cell lines when treated for 48 hours. [J Nat Prod] Abstract

Apoptotic Markers in a Prostate Cancer Cell Line: Effect of Ellagic Acid
Researchers delineated possible apoptotic pathway(s) involved in the ellagic acid (EA)-mediated chemotherapeutic effects in the LNCaP human prostatic cancer cell line. EA produced anti-proliferative effects through inhibition of rapamycin activation and a reduction in intracellular levels of β-catenin. [Oncol Rep] Abstract

Anti-Androgenic Activity of Hydroxyxanthones in Prostate Cancer LNCaP Cells
Investigators report that hydroxyxanthones from a plant extract act as anti-androgens in androgen receptor-positive prostate cancer LNCaP cells. [Fitoterapia] Abstract

Nuclear Targeting of Dystroglycan Promotes the Expression of Androgen Regulated Transcription Factors in Prostate Cancer
Researchers report an analysis of β-dystroglycan in prostate cancer in human tissue samples and in LNCaP cells in vitro. There is progressive loss of β-dystroglycan immunoreactivity from basal and lateral surfaces of prostate epithelia which correlates significantly with increasing Gleason grade. [Sci Rep] Full Article

CLINICAL RESEARCH

Exploratory Analysis of the Visceral Disease Subgroup in a Phase III Study of Abiraterone Acetate in Metastatic Castration-Resistant Prostate Cancer
An exploratory analysis of COU-AA-301 assessed whether abiraterone acetate (AA) improved overall survival (OS) in mCRPC patients with visceral disease progressing post docetaxel. AA plus prednisone produced similar absolute improvement in median OS in patients with and without visceral disease versus prednisone. [Prostate Cancer P D] Full Article

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National Cancer Institute Awards $48.6 Million Grant to MD Anderson
Broad, deep and outstanding research in cancer science, treatment and prevention have earned The University of Texas MD Anderson Cancer Center a $48.6-million, five-year grant from the National Cancer Institute and an “exceptional” ranking, the highest possible, from the National Cancer Institute’s extensive peer-review process. [The University of Texas MD Anderson Cancer Center] Press Release

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NEW Senior Postdoctoral Researcher – Signaling and Metabolic Alterations in Prostate and Breast Cancer (CIC bioGUNE)

Research Technician Position – Steroid Receptor Signaling (Baylor College of Medicine)

Postdoctoral Research Associates – Tumor Immune Evasion Mechanism and Inflammation (Hollings Cancer Center)

Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland Baltimore)

Research Associate – Prostate Cancer (University of Virginia)

Postdoctoral Position – Prostate Cancer Biology (University Of Rochester School Of Medicine)

Postdoctoral Position – Cancer Genomics and Epigenomics (Ontario Cancer Institute / Princess Margaret Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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