LABORATORY RESEARCH TMPRSS2-ERG Gene Fusions Induce Prostate Tumorigenesis by Modulating MicroRNA miR-200c Experimentation of prostate cancer (PCa) cells with ERG overexpression or knockdown demonstrated that ERG directly repressed miR-200c expression by physically binding to the erythroblast transformation-specific motif within its promoter. Consequently, miR-200c was downregulated in ERG-positive PCa, and miR-200c target gene expression was restored. [Oncogene] Abstract Phosphoproteomic Profiling Identifies Focal Adhesion Kinase as a Mediator of Docetaxel Resistance in Castrate Resistant Prostate Cancer Using quantitative mass spectrometry-based phosphoproteomics, researchers identified that metastatic Docetaxel-resistant prostate cancer cell lines exhibit increased phosphorylation of focal adhesion kinase on Y397 and Y576, in comparison to parental controls. [Mol Cancer Ther] Abstract Human Fucosyltransferase 6 Enables Prostate Cancer Metastasis to Bone Overexpression of fucosyltransferase (FT)3, FT6 or FT7 restored E-selectin ligands and enabled mouse prostate cancer (PCa) cells to roll and adhere in E-selectin-functionalized microtubes, similar to trafficking of circulating PCa cells in bone marrow vessels. [Br J Cancer] Full Article Modulators of Estrogen Receptor Inhibit Proliferation and Migration of Prostate Cancer Cells Researchers demonstrated that raloxifen, tamoxifen, genistein and curcumin decreased DU145 and PC3 cell proliferation in a dose-dependent manner; in addition, all four compounds significantly decreased the detachment of cells seeded on laminin or fibronectin. [Pharmacol Res] Abstract Procyanidin B2 3,3?-Di-O-Gallate, a Biologically Active Constituent of Grape Seed Extract, Induces Apoptosis in Human Prostate Cancer Cells Via Targeting NF-?B, Stat3, and AP1 Transcription Factors Researchers synthesized gram-scale quantities of B2 3,3?-di-O-gallate (B2G2), compared it with B2G2 isolated from grape seed extract for possible equivalent biological activity and conducted mechanistic studies. Both B2G2 preparations inhibited cell growth, decreased clonogenicity, and induced cell cycle arrest and apoptotic death, comparable to each other, in various human prostate cancer cell lines. [Nutr Cancer] Abstract The Expression of C-FABP and PPAR? and Their Prognostic Significance in Prostate Cancer The expression levels of cutaneous fatty acid-binding protein (C-FABP) and peroxisome proliferator-activated receptor ? (PPAR?) in prostate cancer cell lines and the cytoplasm and nuclei of carcinoma tissues were significantly higher compared to those in benign cell lines and benign prostatic hyperplasia tissues. [Int J Oncol] Abstract Context-Dependent Role of ATG4B as Target for Autophagy Inhibition in Prostate Cancer Therapy By analyzing PC-3 and C4-2 prostate cancer cells overexpressing dominant negative ATG4BC74A in vitro and in vivo, scientists showed that the effects of ATG4BC74A are cell type, treatment, and context-dependent. [Biochem Biophys Res Commun] Abstract Decreased c-Abl Activity in PC-3 and LNCaP Prostate Cancer Cells Overexpressing the Early Growth Response-1 Protein To study the effect of overexpression of early growth response-1 on the activity of c-Abl in prostate cancer cells, human PC-3 and LNCaP cells were transfected with a control vector or a vector containing the murine Egr-1 cDNA and assessed for the expression of the c-Abl gene. [Oncol Rep] Abstract Regulation of Epithelial Plasticity by miR-424 and miR-200 in a New Prostate Cancer Metastasis Model Using an in vivo cycling strategy, scientists selected metastatic cancer cells from the lymph nodes of mice bearing orthotopic DU145 human prostate tumors. Repeated rounds of metastatic selection progressively increased the epithelial phenotype, resulting in a new model of tumor cell mesenchymal-epithelial transition. [Sci Rep] Full Article CLINICAL RESEARCH Clinical Benefits of Non-Taxane Chemotherapies in Unselected Symptomatic Metastatic Castration-Resistant Prostate Cancer Patients after Docetaxel: The Getug P02 Study Investigators evaluated the overall benefits of non-taxane chemotherapies in a non-selected population including unfit patients presenting with symptoms and pain. [BJU Int] Abstract |