Prostate Cell News Volume 5.09 | Mar 14 2014

The MAP Kinases p38 and ERK Are Involved in Hepatocyte-Mediated Phenotypic Switching in Prostate Cancer Cells
Researchers showed that hepatocytes educate prostate cancer to undergo mesenchymal to epithelial reverting transition by modulating the activity of p38 and ERK1/2. Hepatocytes inhibited p38 and ERK1/2 activity in prostate cancer cells which allowed E-cadherin re-expression. [J Biol Chem] Abstract | Full Article

Rottlerin Induces Wnt Co-Receptor LRP6 Degradation and Suppresses Both Wnt/ß-Catenin and mTORC1 Signaling in Prostate and Breast Cancer Cells
The inhibitory effects of rottlerin on lipoprotein receptor-related protein-6 (LRP6) expression/phosphorylation and Wnt/ß-catenin signaling were confirmed in human prostate cancer PC-3 and DU145 cells and breast cancer MDA-MB-231 and T-47D cells. [Cell Signal] Abstract

Serine Protease Inhibitor Kazal Type 1 Promotes Epithelial-Mesenchymal Transition through EGFR Signaling Pathway in Prostate Cancer
Serine protease inhibitor Kazal type 1 (SPINK1)-induced epithelial-mesenchymal transition (EMT) in benign prostate RWPE cells, manifested by acquisition of mesenchymal morphology, alternation of EMT markers as well as migration and invasion capabilities. Knockdown of SPINK1 in 22RV1 prostate cancer cells results in up-regulation of E-cadherin and down-regulation of vimentin. [Prostate] Abstract

Plant Flavone Apigenin Binds to Nucleic Acid Bases and Reduces Oxidative DNA Damage in Prostate Epithelial Cells
Scientists investigated sub-cellular distribution of apigenin, it’s binding to DNA and protective effects against H₂O₂-induced DNA damage using transformed human prostate epithelial RWPE-1 cells and prostate cancer LNCaP, PC-3 and DU145 cells. [PLoS One] Full Article

Nanoparticles of Star-Like Copolymer Mannitol-Functionalized Poly(Lactide)-Vitamin E TPGS for Delivery of Paclitaxel to Prostate Cancer Cells
The purpose of this research was to develop novel nanoparticles (NPs) of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS (M-PLA-TPGS) for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line and animal model in comparison with the linear PLGA NPs and poly(lactide)-vitamin E TPGS NPs. [J Biomater Appl] Abstract

Stabilization of Snail by HIF-1a and TNF-a Is Required for Hypoxia-Induced Invasion in Prostate Cancer PC3 Cells
Scientists found that hypoxia significantly increased the invasive activity of PC3 cells, via up-regulation of the expression of hypoxia inducible factor 1a (HIF-1a) and the autocrine production of tumor necrosis factor a (TNF-a). [Mol Biol Rep] Abstract

Muscadine Grape Skin Extract Reverts Snail-Mediated Epithelial Mesenchymal Transition via Superoxide Species in Human Prostate Cancer Cells
Researchers investigated novel molecular mechanisms by which Snail promotes epithelial-mesenchymal transition in prostate cancer cells via reactive oxygen species and whether it can be antagonized by muscadine grape skin extract. [BMC Complement Altern Med] Abstract | Full Article

miR-34 Cooperates with p53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment
Scientists report that mice with prostate epithelium-specific inactivation of mir-34 and p53 show expansion of the prostate stem cell compartment and develop early invasive adenocarcinomas and high-grade prostatic intraepithelial neoplasia, whereas no such lesions are observed after inactivation of either the mir-34 or p53 genes alone by 15 months of age. [Cell Rep] Full Article | Graphical Abstract | Press Release

CLINICAL RESEARCH

Circulating Tumor Cell Counts Are Prognostic of Overall Survival in SWOG S0421: A Phase III Trial of Docetaxel With or Without Atrasentan for Metastatic Castration-Resistant Prostate Cancer
Investigators assessed the prognostic value of circulating tumor cells for overall survival and disease response in S0421, a Phase III trial of docetaxel plus prednisone with or without atrasentan. [J Clin Oncol] Abstract

A Double-Blind, Placebo-Controlled Randomized Trial Evaluating the Effect of a Polyphenol-Rich Whole Food Supplement on PSA Progression in Men with Prostate Cancer – The UK NCRN Pomi-T Study
Investigators found a significant short-term, favorable effect on the percentage rise in PSA in men managed with active surveillance and watchful waiting following ingestion of this well-tolerated, specific blend of concentrated foods. [Prostate Cancer Prostatic Dis] Full Article

Contributions of Epithelial-Mesenchymal Transition and Cancer Stem Cells to the Development of Castration Resistance of Prostate Cancer
New emerging evidence indicates that epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) play crucial roles during the development of castration-resistance and metastasis of prostate cancer. The authors review recent progress of EMT and CSCs in castration-resistant prostate cancer. [Mol Cancer]
Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Prostate Embolization Studied at Georgetown for Most Common Prostate Problem in Men
Physicians at MedStar Georgetown University Hospital and Georgetown University Medical Center have just begun to study the safety and effectiveness of prostate artery embolization in men with enlarged prostate glands and urinary obstruction. [MedStar Georgetown University Hospital] Press Release

American Urological Association and Astellas Team Up to Secure the Future of Urology Research through $3 Million Endowment
The American Urological Association and Astellas US LLC announced a $3 million commitment to the Urology Care Foundation and to the promising young urologists seeking careers in academic urology. [The American Urological Association] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the prostate cell community.

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic)

Postdoctoral Fellow – Prostate Cancer (Mayo Clinic- Rochester)

Postdoctoral Fellow – Biomarker Discovery In Prostate Cancer (University of California, San Francisco)

Postdoctoral Position – Cancer Biology/Genomics (Weill Cornell Medical College)

Experienced Researcher – Detection of Prostate Cancer Biomarkers (Dublin City University)

Postdoctoral Fellow – Role of Mitochondria in Cancer Progression (Baylor College of Medicine)

Postdoctoral Position – Prostate Cancer (Roswell Park Cancer Institute)

Postgraduate Position – Chemokine Receptor Induced Cell Migration (University of East Anglia)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.