LABORATORY RESEARCH Eupafolin Suppresses Prostate Cancer by Targeting Phosphatidylinositol 3-Kinase-Mediated Akt Signaling Scientists report that eupafolin, a natural compound found in common sage, inhibited proliferation of prostate cancer cells. [Mol Carcinog] Abstract In Vivo Hyperoxia Induces Hypoxia-Inducible Factor-1a Overexpression in LNCaP Tumors without Affecting the Tumor Growth Rate To test whether hyperoxia and hypoxia have divergent effects, and to better focus into the role of hypoxia-inducible factor-1a in vivo, athymic mice xenografted with LNCaP cells were exposed for 28 days to atmospheres containing 10, 21 or 30% O2. [Int J Biochem Cell Biol] Abstract Torc1/Torc2 Inhibitor, Palomid 529, Enhances Radiation Response Modulating CRM1-Mediated Survivin Function and Delaying DNA Repair in Prostate Cancer Models Six tumor cell lines and xenograft models were used for in vitro and in vivo studies. Clonogenic survival, apoptotic, autophagic, and senescence assays were used to examine the effects of ionizing radiation alone and in combination with P529. [Prostate] Abstract Pterostilbene-Isothiocyanate Conjugate Suppresses Growth of Prostate Cancer Cells Irrespective of Androgen Receptor Status Researchers focused on analyzing the role of pterostilbene (PTER)-isothiocyanate (ITC) conjugate – a novel class of hybrid compound synthesized by appending an ITC moiety on PTER backbone – in regulating the functions of androgen receptor, thereby causing apoptosis of prostate cancer cells. [PLoS One] Full Article Novel Lignan and Stilbenoid Mixture Shows Anticarcinogenic Efficacy in Preclinical PC-3M-luc2 Prostate Cancer Model Scientists assessed the effects of a novel lignan-stilbenoid mixture in PC-3M-luc2 human prostate cancer cells in vitro and in orthotopic xenografts. [PLoS One] Full Article Correlation between Overexpression of EpCAM in Prostate Tissues and Genesis of Androgen-Dependent Prostate Cancer Researchers investigated the role of epithelial cell adhesion molecule (EpCAM) in the genesis and the progress of prostate cancer, especially of castration-resistant prostate cancer. [Tumor Biol] Abstract Camalexin-Induced Apoptosis in Prostate Cancer Cells Involves Alterations of Expression and Activity of Lysosomal Protease Cathepsin D Researchers hypothesized that camalexin reduces cell viability in prostate cancer cells via alterations in expression and activity of cathepsin D. [Molecules] Abstract | Download Full Article Reciprocal Positive Regulation between TRPV6 and NUMB in PTEN-Deficient Prostate Cancer Cells Scientists showed that NUMB and TRPV6 have a reciprocal positive regulatory relationship in PC-3 cells. They repeated this experiment in two other prostate cancer cell lines, DU145 and LNCaP. [Biochem Biophys Res Commun] Abstract CLINICAL RESEARCH Prognostic and Predictive Value of Plasma Testosterone Levels in Patients Receiving First-Line Chemotherapy for Metastatic Castrate-Resistant Prostate Cancer The prognostic and predictive value for survival and response to salvage hormonal therapy of baseline testosterone level was analyzed in a cohort of 101 metastatic castration-resistant prostatic cancer patients participating in nine non-hormonal first-line chemotherapy Phase II-III trials. [Br J Cancer] Abstract Lactate Dehydrogenase 5 Isoenzyme Overexpression Defines Resistance of Prostate Cancer to Radiotherapy Biopsy samples from 83 patients with prostate cancer undergoing radical hypofractionated and accelerated radiotherapy were analyzed for MIB1 proliferation index and for lactate dehydrogenase isoenzyme LDH5, a marker of tumor anaerobic metabolism. [Br J Cancer] Abstract |