Prostate Cell News Volume 6.16 | May 8 2015

KU675, a Concomitant Heat Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells
Researchers report a novel C-terminal 90-kDa heat shock protein (Hsp90) inhibitor, designated KU675, which exhibited potent anti-proliferative and cytotoxic activity along with client protein degradation without induction of the heat shock response in both androgen dependent and independent prostate cancer cell lines. [Mol Pharmacol] Abstract | Full Article

Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration
The authors showed that polymerase I and transcript release factor expression (PTRF) in PC3 cells reduced focal adhesion kinase stabilization in focal adhesions and reduced cell motility without affecting phosphorylated caveolin-1 levels. [PLoS One] Full Article

An Atomic Force Microscope Study Revealed Two Mechanisms in the Effect of Anticancer Drugs on Rate-Dependent Young’s Modulus of Human Prostate Cancer Cells
The effects of eight different anticancer drugs on the mechanical properties of human prostate cancer cell were investigated using a recently developed control-based nanoindentation measurement protocol on atomic force microscope. [PLoS One] Full Article

MicroRNA-19a Regulates Proliferation and Apoptosis of Castration-Resistant Prostate Cancer Cells by Targeting BTG1
Researchers found that microRNA (miR)-19a expression was significantly increased in castration-resistant prostate cancer (CRPC) tissues compared with androgen-dependent prostate cancer tissues. They found that inhibiting the overexpression of miR-19a in CRPC cells suppressed proliferation and increased apoptosis. [FEBS Lett] Abstract

Overexpression of miR-145-5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression
Investigators performed functional analysis of miR-145-5p in prostate cancer (PCa) cells and identified targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. [Cancer Invest] Abstract

Castration-Resistant Lgr⁵⁺ Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration
Investigators demonstrated that leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is expressed in a rare population of prostate epithelial progenitor cells, and a castration-resistant Lgr⁵⁺ population exists in regressed prostate tissue. [Stem Cell Rep] Full Article | Graphical Abstract

The Androgen Receptor Plays a Suppressive Role in Epithelial-Mesenchymal Transition of Human Prostate Cancer Stem Progenitor Cells
Scientists investigated the roles of androgen receptor in epithelial-mesenchymal transition (EMT) in human prostate cancer stem progenitor (S/P) cells isolated from LNCaP cell line. The data showed that S/P cells from LNCaP had high EMT markers expression, more tumorigenesis and strong migration ability. [BMC Biochemistry] Abstract | Full Article

CLINICAL RESEARCH

Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients With Hormone-Sensitive Prostate Cancer
Scientists evaluated whether statin use prolonged time to progression during androgen deprivation therapy for hormone-sensitive prostate cancer. [JAM-J AM Med Assoc] Full Article | Press Release

Survival Outcomes of Sipuleucel-T Phase III Studies: Impact of Control Arm Cross-Over to Salvage Immunotherapy
Sipuleucel-T is an autologous cellular immunotherapy for asymptomatic/minimally symptomatic metastatic castrate-resistant prostate cancer. Investigators explored APC8015F’s effects on control-arm overall survival and treatment effects of sipuleucel-T vs. control adjusted for APC8015F treatment. [Cancer Immunol Res] Abstract | Full Article

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$2 Million Grant to Fund Initial Clinical Trials in Prostate Cancer
An imaging agent discovered by a Washington State University researcher that homes in on prostate cancer will be developed for human clinical trials thanks to a two-year $2 million federal Small Business Innovation Research grant. [Washington State University] Press Release

UB Spinoff Gets $2 Million for Research on Cancer Therapy
For-Robin, a University at Buffalo (UB) spinoff company, has received a $2 million grant from the National Cancer Institute to study and develop a promising potential treatment for breast and other types of cancer, UB and U.S. Congressman Brian Higgins have announced. [University of Buffalo] Press Release

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NEW Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

NEW Postdoctoral Research Fellow/Instructor – Prostate/Breast Cancer (Baylor College of Medicine)

Scientific Officer – Prostate Oncobiology Group (Cancer Research UK Manchester Institute)

Postdoctoral Fellow – Genitourinary Cancers (Geisinger Health System)

Cancer Biologist (Wake Forest Baptist Medical Center)

Postdoctoral Research Fellow – Prostate Cancer and Breast Cancer (Baylor College of Medicine)

Postdoctoral Fellow – Development, Progression and Chemotherapy Resistance of Cancers (University of Maryland School of Medicine)

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