LABORATORY RESEARCH Inhibition of FOXC2 Restores Epithelial Phenotype and Drug Sensitivity in Prostate Cancer Cells with Stem-Cell Properties Investigators identified a critical nexus between p38MAPK signaling, and the transcription factor Forkhead Box Protein C2 (FOXC2) known to promote cancer stem-cells and metastasis. [Oncogene] Full Article Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumor-Promoting and Tumor-Suppressing Roles in Experimental Prostate Cancer Researchers showed that orthotopic implantation of rat prostate AT-1 tumor cells increased lysyl oxidase (LOX) and LOX-like microRNA expressions in the tumor and in the surrounding non-malignant prostate tissue. [Sci Rep] Full Article Phenethyl Isothiocyanate (PEITC) Suppresses Prostate Cancer Cell Invasion Epigenetically through Regulating MicroRNA-194 Altered levels of microRNA (miRNA) have been linked to tumor malignancy due to their capacity to regulate functional gene expression in carcinogenesis. Scientist assessed the effects of PEITC on miRNA expression which is related to prostate cancer cell invasiveness. [Mol Nutr Food Res] Abstract Increase in Prostate Stem Cell Antigen Expression in Prostatic Hyperplasia Induced by Testosterone and 17β-Estradiol in C57BL Mice To understand the mechanisms underlying the hormonal induction of prostatic hyperplasia, the authors investigated the expression of growth factors and their receptors, androgen receptor, estrogen receptor, and prostatic secretory proteins. [J Steroid Biochem Mol Biol] Abstract 3D Cell-SELEX: Development of RNA Aptamers as Molecular Probes for PC-3 Tumor Cell Line Scientists performed three-dimensional Cell-SELEX against PC-3 prostate cancer cell line, a novel strategy to select specific nucleic acid ligands against spheroid cells in three-dimensional cell culture. [Exp Cell Res] Abstract Oncolytic Vaccinia Virus as a Vector for Therapeutic Sodium Iodide Symporter Gene Therapy in Prostate Cancer Scientist evaluated the therapeutic potential of vaccinia virus expressing the sodium iodide symporter (NIS) in prostate cancer models, combining oncolysis, external beam radiotherapy, and NIS-mediated radioiodide therapy. [Gene Ther] Full Article CLINICAL RESEARCH Enzalutamide Versus Bicalutamide in Castration-Resistant Prostate Cancer: The STRIVE Trial A total of 396 men with nonmetastatic or metastatic castration-resistant prostate cancer were randomly assigned to enzalutamide 160 mg per day or bicalutamide 50 mg per day. Androgen deprivation therapy was continued in both arms. The primary end point was progression-free survival. [J Clin Oncol] Full Article 5-Alpha Reductase Inhibitor Use and Prostate Cancer Survival in the Finnish Prostate Cancer Screening Trial The authors studied disease-specific survival by 5α-reductase inhibitors usage in a cohort of 6,537 prostate cancer cases diagnosed in the Finnish Prostate Cancer Screening Trial and linked to the national prescription database for information on medication use. [Int J Cancer] Abstract The Prognostic Role of Preoperative Serum C-Reactive Protein in Predicting the Biochemical Recurrence in Patients Treated with Radical Prostatectomy Preoperative C-reactive protein (CRP) is elevated in patients with pathological features of aggressive prostate cancer and biochemical recurrence after radical prostatectomy. While CRP has independent prognostic value, it does not add prognostically or clinically significant information to standard predictors of outcomes. [Prostate Cancer Prostatic Dis] Abstract |