LABORATORY RESEARCH Stem Cell and Neurogenic Gene-Expression Profiles Link Prostate Basal Cells to Aggressive Prostate Cancer The authors described a genome-wide transcriptome analysis of human benign prostatic basal and luminal epithelial populations using deep RNA sequencing. Through molecular and biological characterizations, they showed that the differential gene-expression profiles account for their distinct functional properties. [Nat Commun] Full Article | Press Release High Throughput Microscopy Identifies Bisphenol AP, a Bisphenol a Analog, as a Novel AR Down-Regulator Researchers used high throughput microscopy and quantitative image analysis to evaluate effects of selected endocrine disruptors on androgen receptor (AR) levels in multiple breast and prostate cancer cell lines. Bisphenol AP (BPAP), which is used in chemical and medical industries, was identified as a down-regulator of both full length AR and the AR-V7 splice variant. [Oncotarget] Full Article Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-Wide DNA Methylation Analysis Investigators performed a MBD-seq analysis on prostate specimens classified into low, high, and very high risk group based on Gleason score and TNM stages. [Sci Rep] Full Article Triiodthyronine Attenuates Prostate Cancer Progression Mediated by β-Andregenic Stimulation Scientists analyzed the effects of β-adrenergic stimulation, and/or thyroid hormones on neuroendocrine differentiation and cell invasion, using in vivo (LNCaP tumor) and in vitro models (LNCaP and DU145 human cells). [Mol Med] Full Article Beta-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation The authors used cDNA knock-in, RNA interference and analysis of mitogenic signaling components in both normal prostate epithelial cells and prostate cancer cells to decipher the proliferation inducing mechanism of the atypical 7-transmebrane chemokine receptor (CXCR7)-epidermal growth factor receptor (EGFR) interaction. [Mol Cancer Res] Abstract Stroma-Induced Jagged1 Expression Drives PC3 Prostate Cancer Cell Migration; Disparate Effects of RIP-Generated Proteolytic Fragments on Cell Behaviour and Notch Signaling Investigators showed that bone marrow stroma induces Jagged1 expression in bone metastatic prostate cancer PC3 cells and that this enhanced expression is mechanistically linked to the promotion of cell migration. [Biochem Biophys Res Commun] Abstract CLINICAL RESEARCH Common Variation in BRCA1 May Have a Role in Progression to Lethal Prostate Cancer after Radiation Treatment Researchers found that two single-nucleotide polymorphisms, rs4473733 and rs8176305, were associated with lethal prostate cancer in men receiving radiation therapy. [Prostate Cancer Prostatic Dis] Abstract Vimentin and Ki67 Expression in Circulating Tumor Cells Derived from Castrate-Resistant Prostate Cancer Researchers asked if the expression of vimentin and Ki67 in circulating tumor cells offered prognostic or predictive information in castrate-resistant prostate cancer. [BMC Cancer] Full Article |