Prostate Cell News 7.29 August 12, 2016 | |
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TOP STORYCompound Shows Promise as Next-Generation Prostate Cancer Therapy In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice. [Press release from Duke Medicine discussing online prepublication in Nature Chemical Biology] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHNovel therapies for men with castration-resistant prostate cancer are needed, particularly for cancers not driven by androgen receptor activation. Researchers aimed to identify molecular subgroups of prostate cancer bone metastases of relevance for therapy. [Eur Urol] Abstract XB130 Is Overexpressed in Prostate Cancer and Involved in Cell Growth and Invasion XB130 is a cytosolic adaptor protein involved in various physiological processes and oncogenesis of certain malignancies, but its role in the development of prostate cancer remains unclear. Researchers examined XB130 expression in prostate cancer tissues and found that XB130 expression was remarkably increased in prostate cancer tissues and significantly correlated with increased prostate specific antigen (PSA), free PSA, prostatic acid phosphatase and T classification. [Oncotarget] Full Article Prostate-Specific Extracellular Vesicles as a Novel Biomarker in Human Prostate Cancer Extracellular vesicles (EVs) may play an important role in cancer development and progression. Scientists aimed to investigate the prognostic potential of prostate-specific EVs in prostate cancer patients. [Sci Rep] Full Article The purpose of this study was to identify alterations in Wnt signaling pathway components involved during prostate cancer progression and to determine the effect of quercetin on transforming growth factor-β-induced epithelial-mesenchymal transition in prostate cancer (PC-3) cell line. [Tumour Biol] Abstract Cadmium (Cd) is a potential human prostate carcinogen. Chronic Cd exposure malignantly transforms RWPE-1 human prostate epithelial cells into CTPE by an unclear mechanism. Investigators determined whether KRAS activation is critical in causing and maintaining Cd-induced malignant transformation in CTPE cells. [Chem Res Toxicol] Abstract Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells Laminin binding integrins α6 and α3 are persistently but differentially expressed in prostate cancer. Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modelling, researchers quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. [J Cell Biochem] Abstract CLINICAL RESEARCHThe Utility of Urine-Circulating MiRNAs for Detection of Prostate Cancer The utility of urine-circulating microRNAs (miRNAs) as the potential biomarker of prostate cancer, the second most prevalent male cancer worldwide, was evaluated. [Br J Cancer] Abstract Tumor Features and Survival after Radical Prostatectomy among Antidiabetic Drug Users Researchers evaluated the association between use of metformin and other antidiabetic drugs with tumor characteristics and survival in surgically managed prostate cancer patients. [Prostate Cancer Prostatic Dis] Abstract Predictors of Duration of Abiraterone Acetate in Men with Castration-Resistant Prostate Cancer Androgen receptor signaling remains important in castration-resistant prostate cancer as demonstrated by the efficacy of abiraterone acetate in phase III trials. Given that heterogeneous patient responses are observed, investigators sought to identify clinical factors associated with duration of abiraterone. [Prostate Cancer Prostatic Dis] Abstract | |
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REVIEWSHypertension and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis The previously reported association between hypertension and prostate cancer risk was controversial. The authors performed a systematic review and meta-analysis of all available studies to summarize evidence of this association. [Sci Rep] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSNymox Announces Prostate Drug Progress Nymox Pharmaceutical Corporation announced major progress in the evidence for the safety and efficacy of fexapotide, the Company’s Phase III drug in the final stages of development for prostate enlargement and for low grade prostate cancer. [Nymox Pharmaceutical Corporation (Globe Newswire)] Press Release UCLA Names Amir Naiberg Associate Vice Chancellor for Research UCLA has named Amir Naiberg associate vice chancellor for research and president and CEO of Westwood Technology Transfer. [University of California, Los Angeles] Press Release | |
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POLICY NEWSOver the past decade, researchers have conducted hundreds of studies on pets to discover new therapies and medicines. The idea is that—unlike lab rodents—cats and dogs live in the same world we do, and naturally get many of the same diseases, so they could hold the key to developing new treatments for people at a fraction of the normal cost, and potentially yield a trove of new drugs for pets themselves. [Science] Editorial Honoring Excellent Lab Safety Performance One important way to help build strong lab safety programs at universities, according to A Guide to Implementing a Safety Culture in Our Universities is to “establish recognition and reward systems” that honor people who exemplify excellent safety performance. The individuals who led the effort to create the report have been formally honored for their work. [Science] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2017 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Tumor Biology (LSU Health Sciences Center) NEW Research Fellow – Prostate Cancer (Queen’s University Belfast) Research Scientist – Functional Cancer Genomics (Institute of Oncology Research – Bellinzona) Senior VP and Director Clinical Research – Oncology (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Breast, Prostate and Pancreatic Cancer (MD Anderson Cancer Center) Faculty Positions – Cancer Immunology (University of New Mexico Health Science Center) Postdoctoral Associate – Cancer Research (Sanford Burnham Prebys Medical Discovery Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Prostate Cell News Volume 7.29 | Aug 12 2016