Prostate Cell News Volume 7.30 | Aug 19 2016

TOP STORY

Modulation of Long Noncoding RNAs by Risk SNPs Underlying Genetic Predispositions to Prostate Cancer

Scientists found PCAT1 promotes prostate cancer cell proliferation and tumor growth in vitro and in vivo. These findings suggest that modulating long noncoding RNAs expression is an important mechanism for risk-associated SNPs in promoting prostate transformation. [Nat Genet] Abstract | Press Release

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

A Glu-Urea-Lys Ligand-Conjugated Lipid Nanoparticle/SiRNA System Inhibits Androgen Receptor Expression In Vivo

Scientists targeted the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression of the messenger RNA encoding the androgen receptor. [Mol Ther Nucleic Acids] Full Article

Miz1, A Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation

Researchers showed Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation although it is not absolutely required. [Prostate] Abstract

A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response

Investigators described the functional characterization of two novel agents, SM253 and SM258, that bind the N-middle linker region of heat shock protein 90 (Hsp90), resulting in reduced client protein activation and preventing C-terminal co-chaperones and client proteins from binding to Hsp90. [Prostate] Abstract

Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells

Using flow cytometry, and first order kinetic modeling, the authors quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. [J Cell Biochem] Abstract

Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer

Researchers investigated the expression and prognostic value of pleomorphic adenoma gene like-2 in prostate cancer. [PLoS One] Full Article

Hsa-miR-135a-1 Inhibits Prostate Cancer Cell Growth and Migration by Targeting EGFR

Differentially expressed microRNAs (miRNAs) are associated with metastatic prostate cancer. However, their potential roles for affecting prostate cancer initiation and progression remain largely unknown. Scientists examined the aberrant expression profiles of miRNAs in human metastatic prostate cancer tissues. [Tumour Biol] Abstract

CLINICAL RESEARCH

Circulating Tumor Cells in a Phase III Study of Docetaxel and Prednisone with or Without Lenalidomide in Metastatic Castration-Resistant Prostate Cancer

Researchers showed in a study of metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy, with or without lenalidomide, that patient survival was best predicted by circulating tumor cell count at the start of treatment. A rising circulating tumor cell count after three cycles of therapy predicted poor survival, while a decline predicted good survival. [Eur Urol] Abstract

Ankyrin G Expression Is Associated with Androgen Receptor Stability, Invasiveness, and Lethal Outcome in Prostate Cancer Patients

Ankyrin G expression in relation to disease progression and patients’ outcome was investigated in two cohorts of prostate cancer (PCA). Mechanistic studies were carried out in vitro and in vivo using several PCA cell lines and the avian embryo model. [J Mol Med] Abstract

Heterogeneity of ERG Expression in Prostate Cancer: A Large Section Mapping Study of Entire Prostatectomy Specimens from 125 Patients

TMPRSS2:ERG fusions are frequent in prostate cancer, and occur predominantly in young patients. Investigators determined frequency and extent of ERG fusion heterogeneity in early-onset prostate cancer and in elderly patients. [BMC Cancer] Abstract

The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers

This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

OncoGenex Announces Results from the Phase III AFFINITY Trial of Custirsen in Men with Metastatic Castrate-Resistant Prostate Cancer

OncoGenex Pharmaceuticals, Inc. announced results from the final analysis of AFFINITY, the Phase III trial of custirsen in men with metastatic castrate-resistant prostate cancer whose disease has progressed after treatment with docetaxel. The trial did not meet the primary endpoint of demonstrating a statistically significant improvement in overall survival for patients treated with custirsen in combination with cabazitaxel/prednisone compared to cabazitaxel/prednisone alone. [OncoGenex Pharmaceuticals, Inc.] Press Release

Mount Sinai and Stony Brook Announce Affiliation

Stony Brook Medicine and the Mount Sinai Health System announced that they are entering into an affiliation agreement that includes collaboration on research, academic programs and clinical care initiatives, effective immediately. The institutions launched the partnership to heighten academic and research synergies and to promote discovery, provide expanded clinical trials for both institutions, and achieve breakthroughs in understanding and treating disease. [Stony Brook Medicine] Press Release

US Personalized-Medicine Industry Takes Hit from Supreme Court

Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial

Mouse Microbes May Make Scientific Studies Harder to Replicate

Experimenters are questioning the potential research impact of the microbiome—a term often used to refer to commensal gut bacteria, but which also includes resident viruses, fungi, protozoa, and single-celled archaea species. [Science] Editorial

Spiking Genomic Databases with Misinformation Could Protect Patient Privacy

Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial

NEW The 2^nd International Conference on Aging and Disease (ICAD 2016)
September 30-October 2, 2017
Stanford, United States

Visit our events page to see a complete list of events in the community.

NEW Professor – Prostate Cancer Research (Boston University School of Medicine)

NEW Postdoctoral Research Fellow – Prostate Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – Tumor Biology (LSU Health Sciences Center)

Research Fellow – Prostate Cancer (Queen’s University Belfast)

Research Scientist – Functional Cancer Genomics (Institute of Oncology Research – Bellinzona)

Senior VP and Director Clinical Research – Oncology (Fred Hutchinson Cancer Research Center)

Assistant/Associate Professor – Genitourinary Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Breast, Prostate and Pancreatic Cancer (MD Anderson Cancer Center)

Postdoctoral Fellow – Epigenetics and Cell Differentiation (Centre National de la Recherche Scientifique)

Associate Editor (PLOS ONE)

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