Prostate Cell News Volume 7.31 | Aug 26 2016

TOP STORY

Zinc-Sensitive MRI Contrast Agent Detects Differential Release of Zn(II) Ions from the Healthy vs. Malignant Mouse Prostate

Scientists showed that glucose stimulates the release of Zn(II) from intracellular stores in healthy prostate tissue and that Zn(II) secretion is reduced in a transgenic adenocarcinoma of the mouse prostate model. [Proc Natl Acad Sci USA] Abstract | Press Release

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

Protein Arginine Methyltransferase 5 Functions as an Epigenetic Activator of the Androgen Receptor to Promote Prostate Cancer Cell Growth

Researchers provide evidence that protein arginine methyltransferase 5 promotes prostate cancer cell growth by epigenetically activating transcription of the androgen receptor in prostate cancer cells. [Oncogene] Full Article

Loss of SLCO1B3 Drives Taxane Resistance in Prostate Cancer

Scientists investigated mechanisms of taxane resistance in prostate cancer. [Br J Cancer] Abstract

Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth

Researchers found that extracellular vesicles (EVs) from metastatic tumors have the ability to prime the prostate tissue and enhance tumor growth to a higher extent than EVs from non-metastatic tumors. [Sci Rep] Full Article

The MET/VEGFR-Targeted Tyrosine Kinase Inhibitor Attenuates FMS-Dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer

Scientists evaluated the efficacy of TAS-115 in preventing prostate cancer metastasis to the bone and bone destruction using the PC3 cell line. [Sci Rep] Full Article

Antagonizing the Androgen Receptor with a Biomimetic Acyltransferase

Researchers explored if the cellular acetyl-transfer activity of thiosalicylamides can be redirected to other cellular targets guided by ligands for the Androgen Receptor. [ACS Chem Biol] Abstract | Graphical Abstract

Modulation of Paracrine Signaling by CD9 Positive Small Extracellular Vesicles Mediates Cellular Growth of Androgen Deprived Prostate Cancer

Scientists identified the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP prostate cancer cells in response to dihydrotestosterone and use nano-LC–MS/MS to identify the proteins present in these EV. [Oncotarget] Full Article

Decreased TSPAN1 Promotes Prostate Cancer Progression and Is a Marker for Early Biochemical Recurrence After Radical Prostatectomy

Researchers focused on TSPAN1, a new member of the tetraspanin family. Its expression was decreased in progressive prostate cancer and was an independent prognosis factor of biochemical recurrence after radical prostatectomy. [Oncotarget] Full Article

CLINICAL RESEARCH

Loss of PTEN Expression in ERG-Negative Prostate Cancer Predicts Secondary Therapies and Leads to Shorter Disease-Specific Survival Time After Radical Prostatectomy

Scientists studied the predictive value of ERG and PTEN expression by immunohistochemistry in two large radical prostatectomy cohorts comprising 815 patients with extensive follow-up information. [Mod Pathol] Abstract

Phenotypic Diversity of Circulating Tumor Cells in Patients with Metastatic Castration-Resistant Prostate Cancer

Scientists utilized a non-biased assay of circulating tumor cells (CTCs) in prostate cancer patients in order to identify non-traditional CTC phenotypes potentially excluded by conventional detection methods reliant upon antigen and/or sized based enrichment. [BJU Int] Abstract

Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer

Investigators identified the androgen receptor variant 7 (AR-V7) status, clinical significance of AR-V7 in hormone sensitive prostate cancer. [Prostate] Abstract

The Interplay Between Cell Signaling and the Mevalonate Pathway in Cancer

This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Pfizer To Acquire Medivation

Pfizer Inc. and Medivation, Inc. announced that they have entered into a definitive merger agreement under which Pfizer will acquire Medivation, a biopharmaceutical company focused on developing and commercializing small molecules for oncology. [Pfizer Inc.] Press Release

Health Science Center, UTSA Gain $4.6 Million for Cancer Research

The Center for Innovative Drug Discovery, a joint program of the UT Health Science Center San Antonio and The University of Texas at San Antonio (UTSA), is receiving a $4,598,728 grant from the Cancer Prevention & Research Institute of Texas. [University of Texas] Press Release

Obama’s Science Legacy: Uneven Progress on Scientific Integrity

As Barack Obama prepares to leave office, Nature examines the scientific highs and lows of his presidency. [Nature] Editorial

New Leader of NIH’s Research Watchdog Faces Staff Revolt

The Office of Research Integrity (ORI) in Rockville, Maryland, which guards against misconduct in biomedical research, usually attracts attention with its findings, not its internal workings. But two years ago, its director, David Wright, quit in a public huff, complaining that ORI was hobbled by a dysfunctional federal bureaucracy. Now, his successor is encountering her own rough waters, Science has learned. [ScienceInsider] Editorial

South African Academics Warn of Universities on the Brink

More than 1,200 South African academics are warning that the country’s university system is at a tipping point as a result of chronic underfunding. [Nature] Editorial

NEW The 2^nd International Conference on Aging and Disease (ICAD 2016)
September 30-October 2, 2017
Stanford, California, United States

Visit our events page to see a complete list of events in the community.

NEW Research Intern – Prostate Cancer (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Researcher – Prostate Cancer (Oregon Health & Science University)

Professor – Prostate Cancer Research (Boston University School of Medicine)

Postdoctoral Researcher – Tumor Biology (LSU Health Sciences Center)

Research Scientist – Functional Cancer Genomics (Institute of Oncology Research – Bellinzona)

Senior VP and Director Clinical Research – Oncology (Fred Hutchinson Cancer Research Center)

Assistant/Associate Professor – Genitourinary Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Breast, Prostate and Pancreatic Cancer (MD Anderson Cancer Center)

Postdoctoral Fellow – Epigenetics and Cell Differentiation (Centre National de la Recherche Scientifique)

Associate Editor (PLOS ONE)

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