Prostate Cell News 7.33 September 9, 2016 | |
| |
TOP STORYNon-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor The authors investigated whether attenuating androgen receptor (AR) activity in prostate luminal cells induces inflammation. Disrupting luminal cell AR signaling in mouse models promotes cytokine production cell-autonomously, impairs epithelial barrier function, and induces immune cell infiltration, which further augments local production of cytokines and chemokines including Il-1 and Ccl2. [Mol Cell] Abstract | Press Release | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHMNX1 Is Oncogenically Upregulated in African-American Prostate Cancer Scientists identified MNX1 as a novel oncogene upregulated to a relatively greater degree in prostate cancer (PCa) from African-American men. Androgen and AKT signaling play a central role in the pathogenesis of PCa and the authors found that both of these signaling pathways increased MNX1 expression. MNX1 in turn upregulated lipid synthesis by stimulating expression of SREBP1 and fatty acid synthetase. [Cancer Res] Abstract | Press Release Loss of CHD1 Causes DNA Repair Defects and Enhances Prostate Cancer Therapeutic Responsiveness Researchers examined the role of CHD1 in DNA double‐strand break (DSB) repair in prostate cancer cells. They showed that CHD1 is required for the recruitment of CtIP to chromatin and subsequent end resection during DNA DSB repair. [EMBO Rep] Abstract | Press release | Graphical Abstract Investigators used in vitro and in vivo models of marrow adiposity, they demonstrated that marrow fat cells promote Warburg phenotype in metastatic prostate cancer cells. They showed increased expression of glycolytic enzymes, increased lactate production, and decreased mitochondrial oxidative phosphorylation in tumor cells exposed to adipocytes that require paracrine signaling between the two cell types. [Oncotarget] Full Article Researchers showed that AR-V7 expression positively correlates with PIP5K1α in tumor specimens from prostate cancer (PCa) patients. Overexpression of AR-V7 increases phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5K1α), promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor ISA-2011B suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7. [Oncotarget] Full Article Researchers hypothesized that the mechanisms whereby integrin α5 (ITGA5) regulates the adhesion-mediated survival of prostate cancer cells will define novel therapeutic approaches. ITGA5 shRNA reduced expression of BCL-2 family members and induced apoptosis in PC-3 cells. [Mol Cancer Res] Abstract In castration-resistant prostate cancer cells, scientists report that miR-27a was downregulated by PI3K signaling. MiR-27a functioned as a tumor suppressor in prostate cancer. Over-expression of miR-27a decreased prostate cancer cell proliferation and migration, and induced prostate cancer cell cycle arrest and apoptosis. [Int J Biochem Cell Biol] Abstract TGF-β Effects on Prostate Cancer Cell Migration and Invasion Require FosB Scientists investigated the role of FOS proteins in TGF-β signaling in prostate cancer cell proliferation, migration, and invasion. [Prostate] Abstract Scientists investigated the effects of naringenin, a natural anti-oxidant flavonoid derived from citrus, on prostate cancer cells (PC3 and LNCaP). Results of this present study with PC3 and LNCaP cells revealed that naringenin inhibited proliferation and migration, while inducing apoptosis and ROS production by those cells. [J Cell Biochem] Abstract To study the therapeutic effects of clinically used anti-androgens, investigators characterized a tissue-mimetic three-dimensional in vitro model whereby prostate cancer (PCa) cells were cultured alone or with PCa-associated fibroblasts. [Int J Mol Sci] Full Article CLINICAL RESEARCHResearchers evaluated the Tn(truncated carbohydrates)-MUC1 glycopeptide in a human Phase I/II clinical trial for safety that followed a preclinical study of different glycosylation forms of MUC1 in rhesus macaques, whose MUC1 is highly homologous to human MUC1. [Cancer Immunol Res] Abstract Decipher Correlation Patterns Post Prostatectomy: Initial Experience from 2 342 Prospective Patients Scientists examined the correlation patterns of Decipher assay to understand the relationship between the Decipher and patient tumor characteristics. [Prostate Cancer Prostatic Dis] Full Article | Press Release | |
| |
REVIEWSImportance of Estrogenic Signaling and Its Mediated Receptors in Prostate Cancer The authors describe how estrogens can also trigger rapid non-genomic signaling responses initiated at the plasma membrane, at least partially via an orphan G-protein-coupled receptor GPR30. Activation of GPR30 significantly inhibited in vitro and in vivo prostate cancer (PCa) cell growth and the underlying mechanism was elucidated. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
| |
INDUSTRY NEWSVPC awarded Terry Fox New Frontiers Program Project Grant 2016 – 2021 The Vancouver Prostate Centre has been awarded $7.5M over 5 years towards six-project, five-core research programs titled “The Terry Fox New Frontiers Program Project in Targeting the adaptive molecular landscape in castrate-resistant prostate cancer”. This carries on from the research performed in previous Terry Fox Program Projects, the first of which was awarded in 1998. [Vancouver Prostate Centre] Press Release Prostate Cancer UK Awards Researchers Crucial Grant for Pioneering Prostate Cancer Study Researchers from the University of the West of England (UWE Bristol) have received a grant of over £136,000 to develop and test a new potential treatment which could be effective in treating as many as half of men with advanced prostate cancer. [University of the West of England (UWE Bristol)] Press Release Millions Awarded to Brightest Research Ideas to Tackle Prostate Cancer From stem cells to bacterial infections, £2.6 million Research Innovation Awards will fund eight potentially game-changing research projects to enhance the understanding and treatment of prostate cancer. [Prostate Cancer UK] Press Release Biocept, Inc. announced a research collaboration with Shilpa Gupta, Ph.D., Assistant Professor in the Hematology Oncology and Transplantation Division of the University of Minnesota to observe the utility of Biocept’s patented Target Selector™ liquid biopsy technology platform using circulating tumor cells to detect the expression of PD-L1 and androgen receptor in patients diagnosed with bladder and prostate cancers. [Biocept, Inc.] Press Release | |
| |
POLICY NEWSAnnouncement: Where Are the Data? As the research community embraces data sharing, academic journals can do their bit to help. Starting this month, all research papers accepted for publication in Nature and an initial 12 other Nature titles will be required to include information on whether and how others can access the underlying data. [Nature News] Editorial Workshop on Ethics of Monkey Research Earns Cheers and Boos Depending on whom you ask, the U.S. government workshop on the state of nonhuman primate research was either a raging success or a complete fiasco. The event, held at the National Institutes of Health brought together dozens of scientists, veterinarians, and bioethicists to discuss how research on monkeys and related animals is contributing to human medicine and to review the welfare policies that surround this work. [ScienceInsider] Editorial Cancer Experts Unveil Wishlist for US Government ‘Moonshot’ Advisers to the US Cancer Moonshot Initiative have produced a wide-ranging laundry list of research targets for the project — even as its funding remains uncertain. The ten recommendations released on 7 September include the launch of a national clinical-trial network specifically targeted at therapies that harness the immune system, and the creation of a 3D cancer atlas to catalogue how a tumour interacts with neighbouring normal cells. [Nature News] Editorial Boom in Unproven Cell Therapies Intensifies Regulatory Debate Controversial US guidelines attempt to rein in rogue stem-cell clinics. [Nature News] Editorial In Wake of Attacks, German Science Bodies Fend for Animal Research Germany’s major research institutes have teamed up to publicly defend “responsible” animal testing as a necessary part of biomedical science. [Science News] Editorial
| |
EVENTSNEW Cell Culture & Downstream World Congress 2017 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Chair of Medical Biology (Masaryk University) Research Intern – Prostate Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Prostate Cancer (Oregon Health & Science University) Professor – Prostate Cancer Research (Boston University School of Medicine) Postdoctoral Researcher – Tumor Biology (LSU Health Sciences Center) Research Scientist – Functional Cancer Genomics (Institute of Oncology Research – Bellinzona) Senior VP and Director Clinical Research – Oncology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Prostate Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Prostate Cell News Volume 7.33 | Sep 09 2016