Prostate Cell News Volume 7.36 | Sep 30 2016

TOP STORY

BIRC6-Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Scientists examined whether BIRC6, an inhibitor of apoptosis protein family member, has a role in enzalutamide (ENZ) resistance of castration-resistant prostate cancer (CRPCs) and could provide a therapeutic target for ENZ-resistant CRPC. [Clin Cancer Res] Abstract

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway

Investigators generated an in vivo model of prostate cancer metastasis via depletion of α3β1 integrin, a correlation observed in a significant proportion of prostate cancers. They described a mechanism whereby α3β1 signals through Abl family kinases to restrain Rho GTPase activity, support Hippo pathway suppressor functions, and restrain prostate cancer migration, invasion, and anchorage-independent growth. [Cancer Res] Abstract

Cell Cycle-Coupled Expansion of AR Activity Promotes Cancer Progression

Scientists identified dihydroceramide desaturase 1 as an androgen receptor (AR)-regulated gene in mitotically active cells that promoted pro-metastatic phenotypes, and in advanced prostate cancer proved to be highly associated with development of metastases, recurrence after therapeutic intervention and reduced overall survival. [Oncogene] Abstract

MnTE-2-PyP Modulates Thiol Oxidation in a Hydrogen Peroxide-Mediated Manner in a Human Prostate Cancer Cell

Researchers provide an in depth mechanism by which MnTE-2-PyP regulates gene transcription through induced H₂O₂ mediated oxidation of particular proteins, supporting an important role for MnTE-2-PyP as an effective and innovative antitumor agent to enhance treatment outcomes in prostate cancer radiotherapy. [Free Radic Biol Med] Abstract

Paracrine Sonic Hedgehog Signaling Contributes Significantly to Acquired Steroidogenesis in the Prostate Tumor Microenvironment

The authors showed exposure of prostate stromal cells (PrSCs) to a smoothened (Smo) agonist, Ag1.5, or to conditioned medium from sonic hedgehog overexpressing LNCaP cells induced steroidogenic enzyme expression in PrSCs and significantly increased production of T and its precursor steroids in a Smo-dependent manner from 22-OH-cholesterol substrate. [Int J Cancer] Abstract

Regulation of PCGEM1 by p54/Nrb in Prostate Cancer

Researchers showed transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. [Sci Rep] Full Article

Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens

The authors developed a highly translational and quantitative bioluminescence microscopy method to measure single cell androgen receptor (AR) activity modulation by antiandrogens from fluid biopsies. They showed that this assay can detect heterogeneous cellular response to drug treatment and that the sum of single cell AR activity can mirror the response in the whole cell population. [Sci Rep] Full Article

Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediate Castration Resistance

The authors present important consequences for clinical castration resistance due to simultaneous expression of full-length AR and androgen receptor splice variants (AR-Vs) in patient tumors and suggests that dissecting these interactions should help develop effective strategies to disrupt AR-V signaling. [Mol Cancer Res] Abstract

Intraprostatic Reflux of Urine Induces Inflammation in a Rat

Scientists examined whether urine reflux into the prostate can induce prostatic inflammation in a rat and evaluated the effect of α1-adrenoreceptor antagonist. [Prostate] Abstract

CLINICAL RESEARCH

A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer

The purpose of this Phase II study was to evaluate mechanisms of resistance to more complete androgen synthesis inhibition with abiraterone and dutasteride. [Clin Cancer Res] Abstract

The Cohesive Metastasis Phenotype in Human Prostate Cancer

The authors examine the evidence for development and dissemination of cohesive-clusters in metastatic prostate cancer. [Biochim Biophys Acta] Abstract

CD147 and Prostate Cancer: A Systematic Review and Meta-Analysis

The authors aimed to systemically evaluate the relationship between the expression of CD147 in tissues and the clinicopathological features of prostate cancer. [PLoS One] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Intermediate Risk Prostate Cancer May Be Well Controlled with Brachytherapy Alone

Initial report of large NRG Oncology/RTOG 0232 study demonstrates effectiveness of prostate brachytherapy as a stand-alone modality for progression free survival. [Press release from the American Society for Radiation Oncology discussing research presented at the 58^th Annual Meeting the American Society for Radiation Oncology (ASTRO), Boston] Press Release

Cardiac Risk a Factor When Considering Hormonal Therapy for Prostate Cancer

A Yale Cancer Center team determined that men who received hormonal therapy for prostate cancer had a net harm if they had a prior history of a heart attack. [Press release from Yale Cancer Center discussing research presented at the American Society for Therapeutic Radiology and Oncology (ASTRO), Boston] Press Release

Three Novel Intrinsic Subtypes of Prostate Cancer Identified

In the largest study of its kind to date, researchers have identified and validated three distinct molecular subtypes of prostate cancer that correlate with distant metastasis-free survival and can assist in future research to determine how patients will respond to treatment. [Press release from the American Society for Radiation Oncology discussing research presented at the 58^th Annual Meeting the American Society for Radiation Oncology (ASTRO), Boston] Press Release

Ambry Genetics Launches Comprehensive Multi-Gene Test for Hereditary Prostate Cancer

Ambry Genetics (Ambry) announced that it has launched ProstateNext, a new 14-gene panel for hereditary prostate cancer. [Press release from Ambry Genetics discussing research to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference, Seattle] Press Release

Xcell Biosciences Initiates New Collaborations with UCSF Researchers Studying Effectiveness of Immunotherapy in Urologic Cancers

Xcell Biosciences, Inc., announced that it has extended its collaborative work with the University of California, San Francisco (UCSF) to include working with three principal investigators on pilot studies using Xcell’s Avatar cell culture system and proprietary analytics platform. [Xcell Biosciences, Inc] Press Release

Principal Investigators at The Wistar Institute Have Secured Nearly $14 Million in Funding

Wistar president and CEO and director of the Institute’s Cancer Center, was awarded a NCI program grant, and will lead the first project, which focuses on understanding new pathways involving energy produced by mitochondria—the powerhouse of cells—and its function in prostate cancer invasion. [The Wistar Institute] Press Release

NEW Challenges, Solutions and Progress in Stem Cell Medicine
February 18-21, 2017
Carlsbad, United States

NEW Advances in Cell Engineering, Imaging and Screening
November 17-18, 2016
Leuven, Belgium

NEW Urologic Biology: Cell Actions and Reactions in Normal and Disease Niches
November 10-13, 2016
Scottsdale, Arizona, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Prostate Cancer Genomics (The Ohio State University, College of Pharmacy)

PhD Student – Molecular Pathways of Prostate Cancer Progression (German Cancer Research Centre – Helmholtz Association)

Postdoctoral Fellow – Prostate Cancer Biology (University of Maryland)

Chair of Medical Biology (Masaryk University)

Postdoctoral Fellow(s) – Uterine Fibroids and Prostate Cancer (University of Texas Health Science Center at San Antonio)

Research Intern – Prostate Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – Prostate Cancer (Oregon Health & Science University)

Professor – Prostate Cancer Research (Boston University School of Medicine)

Research Scientist – Functional Cancer Genomics (Institute of Oncology Research – Bellinzona)

Senior VP and Director Clinical Research – Oncology (Fred Hutchinson Cancer Research Center)

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