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Pulmonary Cell News| Prostate Cell News 8.23 June 23, 2017 | |
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TOP STORYTreatment of therapy-sensitive tumors in heterogeneous tumor microenvironments results in apoptosis of therapy-resistant tumors. Investigators identified a Par-4 amino-terminal fragment that is released by diverse therapy-sensitive cancer cells following therapy-induced caspase cleavage of the tumor suppressor Par-4 protein. PAF caused apoptosis in cancer cells resistant to therapy and inhibited tumor growth. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHThe authors constructed miRNA expression signatures of castration-resistant prostate cancer (CRPC) by comparing the expression of miRNAs between CRPC and normal prostate tissue or hormone-sensitive prostate cancer. Genome-wide gene expression studies and in silico analyses were carried out to predict miRNA regulation and investigate the functional significance and clinical utility of the novel oncogenic pathways regulated by these miRNAs in prostate cancer. [Br J Cancer] Abstract By analyzing micro-RNA expression profiles in a set of patient-derived prostate cancer xenograft tumor lines, scientists identified miR-100-5p as one of the key molecular components in the initiation and evolution of androgen ablation therapy resistance in prostate cancer. [Sci Rep] Full Article Investigators aimed to analyze the complex interdependency between carbonic anhydrase (CA) IX and the tumor microenvironment in prostate tumor cells in concern of potential therapeutic implications. CA IX was up-regulated by hypoxia as well as acidosis in prostate cancer cells. [Oncol Res] Abstract TGX221 analog efficacy was examined in multiple prostate cancer cell lines with the SRB cell growth assay, Western blot assay for AKT phosphorylation and cell cycle protein levels. [Prostate] Abstract Researchers investigated the prognostic potential and regulatory mechanism of microRNA-500 (miR-500), and human gene of tissue factor pathway inhibitor (TFPI) in prostate cancer. MiR-500 expression was assessed by qRT-PCR in prostate cancer cell lines and primary tumors. [Prostate] Abstract Targeting Multiple Pro-Apoptotic Signaling Pathways with Curcumin in Prostate Cancer Cells The authors examined the signaling pathways triggered by curcumin, specifically, the exact molecular mechanisms of curcumin-induced apoptosis in highly metastatic human prostate cancer cells. The effect of curcumin was evaluated using for the first time in prostate cancer, a gel-free shotgun quantitative proteomic analysis coupled with Tandem Mass Tag isobaric labeling-based-signaling networks. [PLoS One] Full Article Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities Galeterone is a steroidal CYP17A1 inhibitor, androgen receptor (AR) antagonist, and AR degrader, under evaluation in a Phase III clinical trial for castration-resistant prostate cancer. Researchers found that galeterone is metabolized by 3βHSD to Δ4-galeterone, which is further converted by steroid-5α-reductase to 3-keto-5α-galeterone, 3α-OH-5α-galeterone, and 3β-OH-5α-galeterone; in vivo it is also converted to the three corresponding 5β-reduced metabolites. [Cell Chem Biol] Abstract | Graphical Abstract | Press Release CLINICAL RESEARCHThe TAXYNERGY trial evaluated clinical benefit from early taxane switch and circulating tumor cell biomarkers to interrogate mechanisms of sensitivity or resistance to taxanes in men with chemotherapy-naïve, metastatic, castration-resistant prostate cancer. [J Clin Oncol] Abstract | |
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REVIEWSExosomes in Diagnosis and Therapy of Prostate Cancer Exosomes deliver nucleic acids and proteins to mediate the communication between cancer cells and stroma cells. The authors summarized recent progress in our understanding of the role of exosomes in prostate cancer. [Oncotarget] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSAugmenix Announces First Prostate Cancer Patient Treated with SpaceOAR® Hydrogel in New Zealand Augmenix, Inc. announced that the first patient in New Zealand has been treated with SpaceOAR® hydrogel at the Kathleen Kilgour Centre in Tauranga. SpaceOAR® hydrogel is the first absorbable spacer designed to separate the rectum and prostate to reduce the risk of long-term side effects after radiation treatment. [Augmenix Inc. [BusinessWire]] Press Release Major Award for Cambridge Researcher Takes Prostate Biopsy Device into Clinical Application Researchers in Cambridge have secured funding of nearly £800,000 from the NIHR Invention for Innovation programme to take a novel test for prostate cancer from a prototype to a CE-marked device for clinical application. [University of Cambridge] Press Release | |
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POLICY NEWSUniversity of Tokyo Scientist Hit by Anonymous Allegations Fights Back Anonymous allegations of questionable data and images in 22 papers by six prominent groups at the prestigious University of Tokyo prompted the school to set up an investigating committee. Now, even before the panel completes its investigation, one of the accused researchers has mounted a staunch defense of his work. [ScienceInsider] Editorial China Cracks Down on Fake Peer Reviews The Chinese government is going on the offensive against scientists who dupe journals by creating fraudulent reviews of submitted papers. A coalition of agencies led by the science ministry announced that the government would suspend the grants of researchers involved in such fraud, which surfaced earlier this year when a cancer journal retracted 107 research papers from Chinese authors. [Nature News] Editorial Strengthened US Sanctions on Cuba Disappoint Scientists US President Donald Trump announced that he would strengthen travel and trade restrictions against Cuba, reversing his predecessor’s attempts to normalize relations with the country. The move is a blow to scientists who hoped that former president Barack Obama’s push to relax US restrictions on Cuba would make it easier for researchers there to travel and to collaborate with colleagues in the United States. [Nature News] Editorial US Court Grants Elsevier Millions in Damages From Sci-Hub One of the world’s largest science publishers, Elsevier, won a default legal judgement against websites that provide illicit access to tens of millions of research papers and books. A New York district court awarded Elsevier US$15 million in damages for copyright infringement by Sci-Hub, the Library of Genesis (LibGen) project and related sites. [Nature News] Editorial
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EVENTSNEW 11th American Association for Cancer Research (AACR)-Japanese Cancer Association (JCA) Joint Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Clinical Research Fellow – Prostate Cancer Vaccine Programme (University of Oxford) NEW Postdoctoral Fellow – Functional Cancer Genomics (Institute of Oncology Research) Postdoctoral Fellow – Epigenetics and Epigenomics (Cleveland Clinic Lerner Research Institute) Postdoctoral Fellows – Cancer Research (Institute of Oncology Research) Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland) Assistant Member – Prostate Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Drug Discovery (The Vancouver Prostate Centre) Research Associate – Prostate Cancer (Meharry Medical College) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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