Prostate Cell News Volume 8.28 | Jul 28 2017

TOP STORY

miR-302/367/LATS2/YAP Pathway Is Essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance

The forced expression of the miR-302/367 cluster accelerated the in vitro and in vivo growth of prostate cancer (PCa) cells and their resistance to androgen ablation, whereas the knockdown of the miR-302/367 cluster using anti-sense RNA suppressed the incidence of formation, growth rate and endpoint weight of PCa cell tumors. [Oncogene] Abstract

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

The Androgen Receptor Is a Negative Regulator of eIF4E Phosphorylation at S209: Implications for the Use of mTOR Inhibitors in Advanced Prostate Cancer

Evaluation of CRPC cell lines identified resistant vs sensitive in vitro models, and revealed that increased eIF4E(S209) phosphorylation is associated with resistance to the combination. [Oncogene] Abstract

Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells

Investigators discovered that quercetin, a naturally occurring polyphenolic compound, reduces the expression of hnRNPA1, and consequently, that of AR-V7. The suppression of AR-V7 by quercetin resensitizes enzalutamide-resistant prostate cancer cells to treatment with enzalutamide. [Mol Cancer Ther] Abstract

Discovery of Thalicthuberine as a Novel Antimitotic Agent from Nature that Disrupts Microtubule Dynamics and Induces Apoptosis in Prostate Cancer Cells

Investigators report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects and asymmetric cell divisions, ultimately leading to mitotic catastrophe accompanied by cell death through apoptosis. [Cell Cycle] Abstract

A Subset of High Gleason Grade Prostate Carcinomas Contain a Large Burden of Prostate Cancer Syndecan-1 Positive Stromal Cells

The authors identified a previously unreported cell type which is marked by syndecan-1 expression and is found in the stroma of prostate tumors and adjacent normal tissue but not in non-diseased prostate. They called these cells prostate cancer syndecan-1 positive cells. [Prostate] Abstract

Differential Proteome Expression Analysis of Androgen-Dependent and -Independent Pathways in LNCaP Prostate Cancer Cells

Scientists examined differences in the proteomes associated with the androgen-dependent and -independent androgen receptor signaling conditions in LNCaP prostate cancer cells. [Exp Cell Res] Abstract

Induction of Alpha-Methylacyl-CoA Racemase by miR-138 via Up-Regulation of β-Catenin in Prostate Cancer Cells

The influence of miR-138 on the expression of alpha-methylacyl-CoA racemase (AMACR) and selected AMACR regulators was investigated in prostate cancer cells. [J Cancer Res Clin Oncol] Abstract

Cytotoxic and Chemosensitization Effects of Scutellarin from Traditional Chinese Herb Scutellaria altissima L. in Human Prostate Cancer Cells

Researchers aimed to ascertain whether Scutellarin inhibits cancer cell growth and to further explore the molecular mechanism. Scutellarin enhanced the sensitivity of prostate cancer cells to cisplatin. [Oncol Rep] Abstract

Antiproliferative Effects of Red and White Wine Extracts in PC-3 Prostate Cancer Cells

The authors showed that red and wine extracts have direct effects on the proliferation, survival, oxidative status, and the induction of autophagy of PC-3 cells. [Nutr Cancer] Abstract

CLINICAL RESEARCH

Clinical Outcomes of Chemotherapy-Naïve Men with Metastatic Castration-Resistant Prostate Cancer and Low Baseline PSA Treated with Enzalutamide vs Placebo

Researchers analyzed outcomes in men with low prostate-specific antigen and high disease burden who received the oral androgen-receptor inhibitor enzalutamide in the PREVAIL study. [J Urol] Abstract

An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

Scientists investigated tolerability, safety and antitumor effects of a novel intra-prostatic depot formulation of antiandrogen 2-hydroxyflutamide in men with localized prostate cancer. [J Urol] Abstract

Recent Advances in Circulating Tumor Cells and Cell-Free DNA in Metastatic Prostate Cancer: A Review

The authors describe technological breakthroughs and clinical implementation of the circulating tumor cells and circulating tumor DNA. They also discuss the key challenges that must be overcome before circulating blood-based biomarkers can be universally adopted into the management of patients with metastatic prostate cancer. [Expert Rev Anticancer Ther] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Jeffrey and Marieke Rothschild Gift Establishes Stanford Center for Cancer Cell Therapy

The Stanford Cancer Institute has received a $10 million gift from Silicon Valley entrepreneur Jeffrey Rothschild and his wife, Marieke, to advance research in cancer cell therapy, which is considered the vanguard of cancer treatment. The gift launches the Stanford Center for Cancer Cell Therapy, which will support research and clinical trials of treatments that use the power of the patients’ own immune system to attack and kill tumor cells. [Stanford Medicine] Press Release

CIRM Approves $5.8 Million Grant for CAR-T Therapy that Targets Cancer Stem Cells

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) unanimously approved a $5.8 million award to University of California San Diego School of Medicine researchers to develop a new immunotherapy in which patients’ cells would be equipped with a special receptor that recognizes and targets cancer stem cells, whose survival abilities often render standard therapies ineffective or short-term. [University of California, San Diego] Press Release

Budding UK Innovation Agency Gains Cash — and Clout

UK scientists fearful for their research funds ahead of Brexit were cheered when the government announced it would plough an extra £4.7 billion (US$6.1 billion) into research and development by 2020–21. But the biggest winner from the largely industry-focused cash may be a government innovation agency that is rapidly gaining clout. [Nature News] Editorial

Senate Spending Panel Would Squeeze Science Agencies but Exceed Trump Request

A Senate spending panel voted to reduce funding in 2018 below current levels for several science agencies under its jurisdiction. [ScienceInsider] Editorial

NEW 6^th Emirates International Urological Conference
November 8-11, 2017
Abu Dhabi, United Arab Emirates

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Associate – Prostate Cancer (University of South Carolina)

Research Technician – Molecular Biology (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences)

Postdoctoral Position – Prostate Cancer (Baylor College of Medicine)

Computational Biologist – Prostate Cancer (Cancer Research UK Manchester Institute)

Post-Doctoral Research Associate Position – Translational Cancer Immunology and Immunotherapy (Northwestern University)

Postdoctoral Scholar Position – Prostate Cancer (Case Western Reserve University)

Postdoctoral Position – Prostate Cancer (Cleveland Clinic)

Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine)

Postdoctoral Fellow – Functional Cancer Genomics (Institute of Oncology Research)

Postdoctoral Fellow – Epigenetics and Epigenomics (Cleveland Clinic Lerner Research Institute)

Postdoctoral Fellows – Cancer Research (Institute of Oncology Research)

Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland)

Assistant Member – Prostate Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Drug Discovery (The Vancouver Prostate Centre)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.