Prostate Cell News 8.43 November 10, 2017 | |
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TOP STORYAcetylated Histone Variant H2A.Z Is Involved in the Activation of Neo-Enhancers in Prostate Cancer Scientists showed that acetylation of the histone variant H2A.Z (H2A.Zac) containing nucleosomes are commonly redistributed to neo-enhancers in cancer resulting in a concomitant gain of chromatin accessibility and ectopic gene expression. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13 Using the CRISPR/Cas9 system, researchers deleted a 4-kb region encompassing several prostate cancer risk-associated SNPs and performed RNA-seq to investigate transcriptomic changes in prostate cells lacking the regulatory element. [Cell Rep] Full Article Scientists analyzed the expression and function of transforming growth factor-beta (TGF-β) signal-associated protein named Sox5 in metastatic castration-resistant prostate cancer. [Br J Cancer] Abstract Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1 Investigators demonstrated that in sigma-1 receptor (Sigma1)-expressing triple negative breast and androgen-independent prostate cancer cells, programmed death-ligand 1 (PD-L1) protein levels were suppressed by RNAi knockdown of Sigma1 and by small molecule inhibition of Sigma1. [Mol Cancer Res] Abstract δ-Tocopherol Inhibits the Development of Prostate Adenocarcinoma in Prostate Specific Pten-/- Mice The authors investigated whether δ-T inhibits the development of prostate adenocarcinoma in prostate-specific Pten-/- mice in which the activation of AKT is the major driving force for tumorigenesis. [Carcinogenesis] Abstract Scientists characterized if hepatocyte growth factor activator inhibitor-2 (HAI-2) was a cognate inhibitor for matriptase and identified which Kunitz domain of HAI-2 was required for inhibiting matriptase and human prostate cancer cell motility. [Sci Rep] Full Article Researchers demonstrated the efficacy of therapeutic-ultrasound to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. [Sci Rep] Full Article SPOP-Mediated Degradation of BRD4 Dictates Cellular Sensitivity to BET Inhibitors Scientists report that prostate cancer-derived SPOP mutants fail to interact with and promote BRD4 degradation, leading to accumulation of BRD4 in prostate cancer cells. [Cell Cycle] Abstract Researchers performed parallel microarray profiling of RNA isolated from non-malignant, malignant, and metastatic prostate cell lines treated with sarcosine. [Prostate] Abstract LQB-118 efficacy and mechanism of activity, were examined in prostate cancer (PCa) cell and tumor models. PC3, LNCaP, and LAPC4 PCa cells were applied. [Prostate] Abstract | |
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REVIEWSProstate Cancer Immunotherapy: Where Are We and Where Are We Going? The authors present the progress and current landscape for prostate cancer immunotherapy and overview recent scientific findings that shed novel insights into immunoresistance and discuss potential therapeutic strategies. [Curr Opin Urol] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSThe National Cancer Institute has awarded Ramon Parsons, MD, PhD, the prestigious Outstanding Investigator Award, granting him $6.7 million over seven years for research into the tumor-suppressing functions of the PTEN gene, which he discovered. [Mount Sinai Hospital] Press Release SOTIO Completes Enrolment of Phase III VIABLE Study in Late Stage Prostate Cancer SOTIO announced the enrolment of the last patient into the VIABLE study, a global Phase III clinical trial evaluating DCVAC/PCa in combination with docetaxel in patients with metastatic castration resistant prostate cancer. [SOTIO] Press Release | |
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POLICY NEWSWHO Calls for Restrictions on Use of Antibiotics in Food Animal Production The World Health Organization (WHO) is urging countries to restrict the amount of antibiotics given in food animal production by prohibiting their routine use in growth promotion and disease prevention. The recommendation is one of a number the WHO issued aimed at preserving the effectiveness of antibiotics. [STAT News] Editorial UK Government Appoints Next Chief Scientific Adviser Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial Indian Scientists Urged to Speak Out about Pseudoscience A leading Indian science-advocacy group is urging the country’s researchers to speak out against pseudoscience, which it fears has gained a foothold in the past few years, partly through support from some agencies of the Indian government. [Nature News] Editorial Court Demands that Search Engines and Internet Service Providers Block Sci-Hub The American Chemical Society (ACS) has won a lawsuit against Sci-Hub, a website providing illicit free access to millions of paywalled scientific papers. ACS had alleged copyright infringement, trademark counterfeiting and trademark infringement; a district court in Virginia ruled that Sci-Hub should pay the ACS $4.8 million in damages after Sci-Hub representatives failed to attend court. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2018 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Cancer Research (Duke University) Postdoctoral Position – Drug Discovery for Advanced Prostate Cancer (Lerner Research Institute) PhD Studentships – Prostate Cancer (Institute of Cancer Research) Postdoctoral Position – Cancer Biology (The Henry Ford Health System) Doctoral Student – Prostate Cancer (Lund University) Postdoctoral Position – Cancer Biology and Epigenetics (Duke University) Researcher – Cancer Biology (University of Cincinnati) Postdoctoral Position – Prostate Cancer (Baylor College of Medicine) Postdoctoral Position – Prostate Related Diseases (Baylor College of Medicine) Postdoctoral Fellow – Drug Discovery (Vancouver Prostate Centre) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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