| Vol. 10.03 – 28 January, 2021 |
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| In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets involved in alveolar repair. [Thorax] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The biological functions of D. rotundifolia were explored in vitro following the treatment of bronchial epithelial cells, which are the potential targets of the pharmacological effects of the herbal medicine. [Scientific Reports] |
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| While searching for an anti-fine dust particle (FDP) reagent, scientists found that green tea extract and fractions rich in flavonol glycosides and crude tea polysaccharides had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line. [Scientific Reports] |
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| The authors discovered that exosomes obtained from hypoxic lung adenocarcinoma cells improved the migration, invasion and proliferation capacity of normoxic lung adenocarcinoma cells. [Molecular Therapy-Nucleic Acids] |
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| Researchers employed lncRNA array technology to identify differentially expressed lncRNAs in NSCLC cells with or without overexpression of megakaryocytic leukemia 1. [Cell Death & Disease] |
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| Investigators found that miR-486-3p was low-expressed in lung cancer. miR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells. [Cancer Gene Therapy] |
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| Researchers investigated the functional role of ROR1‐AS1 in NSCLC and explored the underlying mechanisms. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐tetrazolium bromide assay was performed to detect cell proliferation. [Journal of Biochemical and Molecular Toxicology] |
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| Scientists indicated that exposure of normal and cancer lung cell lines to waterpipe tobacco smoking condensate resulted in a decrease in their in vitro growth in a dose-dependent manner and it induced tumor senescence. [Oncology Reports] |
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| Several studies are currently underway to develop novel diagnostic and prognostic modalities using lung cancer cell-derived exosomes (LCCDEs), and to develop methods of exploiting exosomes for use as efficient drug delivery vehicles. Current status of lung cancer and extensive applicability of LCCDEs are illustrated in this review. [Molecular Cancer] |
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| Organicell Regenerative Medicine, Inc. announced that the FDA has approved the Investigational New Drug application for its lead product, Zofin™, in the treatment of patients diagnosed with COPD. [Organicell Regenerative Medicine, Inc.] |
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| United Therapeutics Corporation announced that the BREEZE study of Tyvaso DPI met its primary objective of demonstrating safety and tolerability in patients with pulmonary arterial hypertension transitioning from Tyvaso Inhalation Solution. In addition, a pharmacokinetic study in healthy volunteers demonstrated comparable treprostinil exposure between Tyvaso DPI and Tyvaso Inhalation Solution. [United Therapeutics Corporation] |
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| UT Health Science Center at Tyler – Tyler, Texas, United States |
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| Justus Liebig University Giessen – Giesen, Germany |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| University of California, San Francisco – San Francisco, California, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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