Pulmonary Cell News Volume 10.03 | Jan 28 2021

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    2020-28-01 | PULCN 10.03


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.03 – 28 January, 2021
    TOP STORY

    Pretreatment of Aged Mice with Retinoic Acid Supports Alveolar Regeneration via Upregulation of Reciprocal PDGFA Signaling

    In vitro organoids generated from epithelial cells of mouse or patient with idiopathic pulmonary fibrosis co-cultured with young, aged or retinoic acid-pretreated murine fibroblasts were used to test potential targets involved in alveolar repair.
    [Thorax]

    AbstractFull Article

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    Low-Dose Drosera rotundifolia Induces Gene Expression Changes in 16HBE Human Bronchial Epithelial Cells

    The biological functions of D. rotundifolia were explored in vitro following the treatment of bronchial epithelial cells, which are the potential targets of the pharmacological effects of the herbal medicine.
    [Scientific Reports]

    Full Article

    Application of Green Tea Catechins, Polysaccharides, and Flavonol Prevent Fine Dust Induced Bronchial Damage by Modulating Inflammation and Airway Cilia

    While searching for an anti-fine dust particle (FDP) reagent, scientists found that green tea extract and fractions rich in flavonol glycosides and crude tea polysaccharides had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line.
    [Scientific Reports]

    Full Article

    Hypoxic Tumor-Derived Exosomal Circular RNA SETDB1 Promotes Invasive Growth and EMT via the miR-7–Sp1 Axis in Lung Adenocarcinoma

    The authors discovered that exosomes obtained from hypoxic lung adenocarcinoma cells improved the migration, invasion and proliferation capacity of normoxic lung adenocarcinoma cells.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    MKL1-Induced lncRNA SNHG18 Drives the Growth and Metastasis of Non-Small Cell Lung Cancer via the miR-211-5p/BRD4 Axis

    Researchers employed lncRNA array technology to identify differentially expressed lncRNAs in NSCLC cells with or without overexpression of megakaryocytic leukemia 1.
    [Cell Death & Disease]

    Full Article

    Circular RNA FLNA Acts as a Sponge of miR-486-3p in Promoting Lung Cancer Progression via Regulating XRCC1 and CYP1A1

    Investigators found that miR-486-3p was low-expressed in lung cancer. miR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells.
    [Cancer Gene Therapy]

    Full Article

    ROR1‐AS1 Knockdown Inhibits Growth and Invasion and Promotes Apoptosis in NSCLC Cells by Suppression of the PI3K/Akt/mTOR Pathway

    Researchers investigated the functional role of ROR1‐AS1 in NSCLC and explored the underlying mechanisms. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐tetrazolium bromide assay was performed to detect cell proliferation.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Waterpipe Smoke Condensate Influences Epithelial to Mesenchymal Transition and Interferes with the Cytotoxic Immune Response in Non-Small Cell Lung Cancer Cell Lines

    Scientists indicated that exposure of normal and cancer lung cell lines to waterpipe tobacco smoking condensate resulted in a decrease in their in vitro growth in a dose-dependent manner and it induced tumor senescence.
    [Oncology Reports]

    AbstractFull Article

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    REVIEWS

    Progress on Pivotal Role and Application of Exosome in Lung Cancer Carcinogenesis, Diagnosis, Therapy and Prognosis

    Several studies are currently underway to develop novel diagnostic and prognostic modalities using lung cancer cell-derived exosomes (LCCDEs), and to develop methods of exploiting exosomes for use as efficient drug delivery vehicles. Current status of lung cancer and extensive applicability of LCCDEs are illustrated in this review.
    [Molecular Cancer]

    Full Article

    INDUSTRY AND POLICY NEWS

    Organicell Announces FDA Approval of IND Application for the Use of Zofin™ in the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

    Organicell Regenerative Medicine, Inc. announced that the FDA has approved the Investigational New Drug application for its lead product, Zofin™, in the treatment of patients diagnosed with COPD.
    [Organicell Regenerative Medicine, Inc.]

    Press Release

    United Therapeutics Announces BREEZE Study of Investigational Tyvaso DPI™ Meets Primary Objective

    United Therapeutics Corporation announced that the BREEZE study of Tyvaso DPI met its primary objective of demonstrating safety and tolerability in patients with pulmonary arterial hypertension transitioning from Tyvaso Inhalation Solution. In addition, a pharmacokinetic study in healthy volunteers demonstrated comparable treprostinil exposure between Tyvaso DPI and Tyvaso Inhalation Solution.
    [United Therapeutics Corporation]

    Press Release

    FEATURED EVENT

    Wisconsin Stem Cell Symposium: The Single Cell Revolution in Stem Cells

    April 14, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – M. tuberculosis Infection

    UT Health Science Center at Tyler – Tyler, Texas, United States

    PhD Student Position – Pulmonary Infections

    Justus Liebig University Giessen – Giesen, Germany

    Postdoctoral Fellow – Cancer Metabolism

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Postdoctoral Fellowship – Stem Cell Biology/Lung Biology

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Fellowship – Lung Cancer Research

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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