| Vol. 10.04 – 4 February, 2021 |
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| Researchers identified the histone H3 lysine 36 methyltransferase NSD3, the gene for which is located in the 8p11–12 amplicon, as a key regulator of lung squamous cell carcinoma tumorigenesis. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report the activation and repression of innate immune response by SARS-CoV-2. They showed that SARS-CoV-2 RNA activated the RIG-I-MAVS-dependent interferon signaling pathway. [Cell Reports] |
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| Investigators sought to determine which metabolic pathways are utilized by human bronchial epithelial cells to mount innate immune responses upon exposure to a relevant bacterial agonist. [Mucosal Immunology] |
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| Researchers examined the modulatory effect of carboxylated nanodiamonds on the cell division, migration, and adhesion of epithelial cells in the well-established in vitro model of wound repair and cell migration. [Toxicology Letters] |
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| Scientists showed that cigarette smoke extract and carcinogen benzo(a)pyrene increased ACE2 mRNA but triggered ACE2 protein catabolism. [Frontiers of Medicine] |
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| Investigators used whole-genome sequencing of 85 cases found to be RTK/RAS/RAF pathway alteration(−) by previous studies from The Cancer Genome Atlas to characterize the minority of lung adenocarcinomas lacking apparent alterations in this pathway. [Cell Reports] |
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| The authors investigated the role of protein tyrosine phosphatase L1 (PTPL1)/PTPN13 in metastasis of lung cancer and the signaling pathways regulated by PTPL1 in terms of epithelial-mesenchymal transition of NSCLC cells. [Acta Pharmacologica Sinica] |
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| Researchers investigated the role and regulatory mechanism of lncRNA APCDD1L-AS1 in icotinib resistance of lung cancer. [Biomarker Research] |
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| Scientists engineered a closed-loop fluidic system to analyze molecular changes induced by variations in flow rate and pressure on primary tumor-derived lung adenocarcinoma cells. [Scientific Reports] |
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| Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells. [Environmental Toxicology] |
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| The authors review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids. [Stem Cell Research & Therapy] |
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| Daiichi Sankyo Company, Limited announced that the first patient has been dosed in HERTHENA-Lung01, a Phase II study evaluating patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate, in patients with epidermal growth factor receptor (EGFR)-mutated metastatic or locally advanced NSCLC previously treated with a tyrosine kinase inhibitor and platinum-based chemotherapy. [Daiichi Sankyo Company, Limited] |
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| MAIA Biotechnology, Inc. announced a clinical supply agreement with Regeneron Pharmaceuticals, Inc. to evaluate THIO followed by the PD-1 inhibitor Libtayo®, in a Phase I/II clinical trial in second-line or later advanced non-small cell lung cancer patients who have progressed following treatment with standard-of-care regimen that includes a checkpoint inhibitor. [MAIA Biotechnology, Inc. (Business Wire, Inc.)] |
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| McKesson has joined together with life sciences companies, oncology providers and patient advocacy groups in a unique collaborative effort, titled MYLUNG, to advance precision medicine options for non-small cell lung cancer patients who are being treated in the community. [McKesson (Business Wire, Inc.)] |
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| May 14 – 19, 2021 Virtual |
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| Oslo University Hospital – Oslo, Norway |
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| UT Health Science Center at Tyler – Tyler, Texas, United States |
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| Justus Liebig University Giessen – Giesen, Germany |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| University of California, San Francisco – San Francisco, California, United States |
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