Pulmonary Cell News Volume 10.04 | Feb 4 2021

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    2020-02-04 | PULCN 10.04


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 10.04 – 4 February, 2021
    TOP STORY

    Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer

    Researchers identified the histone H3 lysine 36 methyltransferase NSD3, the gene for which is located in the 8p11–12 amplicon, as a key regulator of lung squamous cell carcinoma tumorigenesis.
    [Nature]

    Abstract

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    SARS-CoV-2 ORF9b Inhibits RIG-I-MAVS Antiviral Signaling by Interrupting K63-Linked Ubiquitination of NEMO

    The authors report the activation and repression of innate immune response by SARS-CoV-2. They showed that SARS-CoV-2 RNA activated the RIG-I-MAVS-dependent interferon signaling pathway.
    [Cell Reports]

    Full ArticleGraphical Abstract

    mTOR-Driven Glycolysis Governs Induction of Innate Immune Responses by Bronchial Epithelial Cells Exposed to the Bacterial Component Flagellin

    Investigators sought to determine which metabolic pathways are utilized by human bronchial epithelial cells to mount innate immune responses upon exposure to a relevant bacterial agonist.
    [Mucosal Immunology]

    Abstract

    Nanodiamonds Inhibit Scratch-Wound Repair in Lung Epithelial Cell Monolayers by Blocking Cell Migration and Inhibiting Cell Proliferation

    Researchers examined the modulatory effect of carboxylated nanodiamonds on the cell division, migration, and adhesion of epithelial cells in the well-established in vitro model of wound repair and cell migration.
    [Toxicology Letters]

    Abstract

    Degradation of SARS-CoV-2 Receptor ACE2 by the E3 Ubiquitin Ligase Skp2 in Lung Epithelial Cells

    Scientists showed that cigarette smoke extract and carcinogen benzo(a)pyrene increased ACE2 mRNA but triggered ACE2 protein catabolism.
    [Frontiers of Medicine]

    Abstract

    Whole-Genome Characterization of Lung Adenocarcinomas Lacking the RTK/RAS/RAF Pathway

    Investigators used whole-genome sequencing of 85 cases found to be RTK/RAS/RAF pathway alteration(−) by previous studies from The Cancer Genome Atlas to characterize the minority of lung adenocarcinomas lacking apparent alterations in this pathway.
    [Cell Reports]

    Full ArticleGraphical Abstract

    PTPL1 Suppresses Lung Cancer Cell Migration via Inhibiting TGF-β1-Induced Activation of p38 MAPK and Smad 2/3 Pathways and EMT

    The authors investigated the role of protein tyrosine phosphatase L1 (PTPL1)/PTPN13 in metastasis of lung cancer and the signaling pathways regulated by PTPL1 in terms of epithelial-mesenchymal transition of NSCLC cells.
    [Acta Pharmacologica Sinica]

    Abstract

    LncRNA APCDD1L-AS1 Induces Icotinib Resistance by Inhibition of EGFR Autophagic Degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 Axis in Lung Adenocarcinoma

    Researchers investigated the role and regulatory mechanism of lncRNA APCDD1L-AS1 in icotinib resistance of lung cancer.
    [Biomarker Research]

    Full Article

    Circulatory Shear Stress Induces Molecular Changes and Side Population Enrichment in Primary Tumor-Derived Lung Cancer Cells with Higher Metastatic Potential

    Scientists engineered a closed-loop fluidic system to analyze molecular changes induced by variations in flow rate and pressure on primary tumor-derived lung adenocarcinoma cells.
    [Scientific Reports]

    Full Article

    Potential Chemotherapeutic Effect of Betalain against Human Non‐Small Cell Lung Cancer through PI3K/Akt/mTOR Signaling Pathway

    Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells.
    [Environmental Toxicology]

    Abstract

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    REVIEWS

    Lung Organoids, Useful Tools for Investigating Epithelial Repair after Lung Injury

    The authors review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    HERTHENA-Lung01 Phase II Study of Daiichi Sankyo’s Patritumab Deruxtecan Initiated in Patients with EGFR-Mutated NSCLC

    Daiichi Sankyo Company, Limited announced that the first patient has been dosed in HERTHENA-Lung01, a Phase II study evaluating patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate, in patients with epidermal growth factor receptor (EGFR)-mutated metastatic or locally advanced NSCLC previously treated with a tyrosine kinase inhibitor and platinum-based chemotherapy.
    [Daiichi Sankyo Company, Limited]

    Press Release

    MAIA Biotechnology, Inc. Announces Clinical Supply Agreement with Regeneron for Phase I/II Clinical Trial Evaluating THIO in Sequential Administration with Libtayo® (Cemiplimab) in Advanced Non-Small Cell Lung Cancer

    MAIA Biotechnology, Inc. announced a clinical supply agreement with Regeneron Pharmaceuticals, Inc. to evaluate THIO followed by the PD-1 inhibitor Libtayo®, in a Phase I/II clinical trial in second-line or later advanced non-small cell lung cancer patients who have progressed following treatment with standard-of-care regimen that includes a checkpoint inhibitor.
    [MAIA Biotechnology, Inc. (Business Wire, Inc.)]

    Press Release

    MYLUNG Study Launches, Aiming to Advance Use of Precision Medicine for Metastatic Non-Small Cell Lung Cancer Patients

    McKesson has joined together with life sciences companies, oncology providers and patient advocacy groups in a unique collaborative effort, titled MYLUNG, to advance precision medicine options for non-small cell lung cancer patients who are being treated in the community.
    [McKesson (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    American Thoracic Society International Conference 2021

    May 14 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Lung-on-a-Chip Development

    Oslo University Hospital – Oslo, Norway

    Postdoctoral Position – M. tuberculosis Infection

    UT Health Science Center at Tyler – Tyler, Texas, United States

    PhD Student Position – Pulmonary Infections

    Justus Liebig University Giessen – Giesen, Germany

    Postdoctoral Fellow – Cancer Metabolism

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Postdoctoral Fellowship – Stem Cell Biology/Lung Biology

    University of California, San Francisco – San Francisco, California, United States

    > See All Jobs

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