 | | Vol. 10.06 – 19 February, 2021 |
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| There is an urgent need for robust and practical in vitro model systems to investigate viral pathogenesis. The authors generated human induced pluripotent stem cell-derived lung organoids, cerebral organoids, neural progenitor cells, neurons and astrocytes.
[Stem Cell Reports] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | Researchers applied human induced pluripotent stem cell-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2.
[Stem Cell Reports] |
| | Researchers designed a series of peptides mimicking the N-terminal helix of human angiotensin converting enzyme 2 (ACE2) protein which contains most of the contacting residues at the binding site, exhibiting a high helical folding propensity in aqueous solution.
[Communications Biology] |
| | Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PMM2.5.
[European Journal of Pharmacology] |
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| Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy] |
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| Investigators combined single cell Raman spectroscopy with group and basis restricted non-negative matrix factorisation to identify individual biochemical changes associated with radiation exposure in three human cancer cell lines.
[Scientific Reports] |
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| Scientists observed that chronic intermittent hypoxia endowed lung cancer with greater metastatic potential, evidenced by increased tumor growth, tumor seeding, and upregulated cancer stem cells-related gene expression in the lungs.
[Respiratory Research] |
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| The authors investigated the function of the cancer stem cell marker aldehyde dehydrogenase in retinoic acid cell signalling using an in vitro model of cisplatin resistant NSCLC.
[Translational Oncology] |
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| The authors examine the pivotal role of pulmonary airway epithelial cells in initiating and moderating tissue repair and restitution.
[Cells] |
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| The potential role of miR-146a as a diagnostic marker of lung cancer must be analyzed. Scientists summarize the tumor-suppressing, anti-inflammatory, and antichemoresistive nature of miR-146a in lung cancer.
[Diagnostics] |
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| Avacta Group plc announced that it has received approval from the Medicines and Healthcare Products Regulatory Agency for its CTA in the UK for a Phase I study of its lead pre|CISIONTM pro-drug, AVA6000 pro-doxorubicin.
[Avacta Group plc] |
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| Diffusion Pharmaceuticals, Inc. announced completion and topline data from the open-label, Phase Ib clinical trial of its novel, diffusion-enhancing therapeutic, trans sodium crocetinate (TSC), in hospitalized COVID-19 patients with confirmed hypoxemia, the most common cause of tissue hypoxia.
[Diffusion Pharmaceuticals, Inc.] |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | Justus Liebig University Giessen – Giesen, Germany |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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Cancer Stem Cell News
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