Neonatal Hyperoxia Stimulates the Expansion of Alveolar Epithelial Type II Cells Since hyperoxia inhibits cell proliferation, researchers hypothesized it depletes the adult lung of type II cells by inhibiting their proliferation at birth. Newborn mice were exposed to room air or hyperoxia and the oxygen-exposed mice were recovered in room air. [Am J Respir Cell Mol Biol] Abstract NADPH Oxidase Mediates Synergistic Effects of IL-17 and TNF-α on CXCL1 Expression by Epithelial Cells after Lung Ischemia-Reperfusion Scientists tested the hypothesis that IL-17 and TNF-α synergistically mediate CXCL1 (a potent neutrophil chemokine) production by alveolar type II epithelial cells via an NADPH oxidase-dependent mechanism during lung ischemia-reperfusion. [Am J Physiol Lung Cell Mol Physiol] Abstract Altered MicroRNA Expression Profile during Epithelial Wound Repair in Bronchial Epithelial Cells To investigate the possible involvement of microRNA (miRNA) in epithelial repair, investigators analyzed miRNA expression profiles during epithelial repair in a cell culture model using TaqMan-based quantitative real-time PCR in a TaqMan Low Density Array format. [BMC Pulm Med] Abstract | Full Article Penta- and Octa-Bromodiphenyl Ethers Promote Proinflammatory Protein Expression in Human Bronchial Epithelial Cells In Vitro Investigators examined commercial penta-diphenyl ethers (BDEs), octa-BDE, and deca-BDE. Human bronchial epithelial cells were exposed to each polybrominated diphenyl ethers for 24 hours. Subsequently, the expression of intercellular adhesion molecule-1 and proinflammatory cytokines were investigated. [Toxicol In Vitro] Abstract Inhibition of Toll-Like Receptor 2-Mediated Response in Human Alveolar Epithelial Cells by Mycolic Acids and Mycobacterium tuberculosis mce1 Operon Mutant Researchers compared the chemokine expression patterns of human epithelial cell line A549 and RAW 264.7 macrophage cells infected with wild type M. tuberculosis H37Rv against patterns induced by a mutant that accumulates free mycolic acids in its cell wall. [Pathog Dis] Abstract LUNG CANCER A Gene Signature of Bone Metastatic Colonization Sensitizes for Tumor-Induced Osteolysis and Predicts Survival in Lung Cancer Bone metastasis of lung adenocarcinoma is a frequent complication of advanced disease. Researchers aimed to identify key mediators conferring robust prometastatic activity with clinical significance. [Oncogene] Abstract NEDD9 Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition Researchers demonstrated that NEDD9 knockdown significantly inhibits migration, invasion and metastasis of lung cancer cells in vitro and in vivo. [Int J Cancer] Abstract Ca2+/Calmodulin-Dependent Protein Kinase IIγ, a Critical Mediator of the NF-κB Network, Is a Novel Therapeutic Target in Non-Small Cell Lung Cancer Scientists demonstrated that Ca2+/calmodulin-dependent protein kinase IIγ is a critical molecular switch of continuous activation of nuclear factor-kappa B (NF-κB) in non-small cell lung cancer. [Cancer Lett] Abstract Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 µg·mL−1. [Mar Drug] Abstract | Full Article Potential Diagnostic Value of miR-155 in Serum from Lung Adenocarcinoma Patients Using in vitro studies, the authors found that microRNA-155 (miR-155) could be a candidate plasmatic biomarker for diagnosing lung cancer. They assessed the differences in levels of miR-21, miR-155, carcinoembryonic antigen and carbohydrate antigen 125 expression in serum samples between lung cancer patients and healthy controls. [Oncol Rep] Abstract |